Progestogen-only’ contraceptives are presented as injections, implants, oral formulations, hormone-releasing intrauterine methods, and emergency contraceptives. The research designed to assess the influence of progesterone in different progesterone containing contraceptive methods on endogenous progesterone level and ovulation rate.
This prospective cohort observational research was involved 80 healthy fertile females aged 20–35 years with normal menstrual history and had at least one offspring after spontaneous pregnancy. Subjects were classified into 4 equal groups according to contraceptive method: D group: used the injectable progesterone of 150 mg every 90 days or 3 months (Depo-Provera), I group: etonogestrel implant which contains 68 mg of etonogestrel, formerly known as Implanon, N group: used norgestrel (Ovrette, with each pill containing 0.075 mg of norgestrel), M group: used IUD (Mirena) containing 52 mg of levonorgestrel.
women who in M group had higher endogenous progesterone level compared to those who used other contraceptives containing with normal follicle growth and normal follicle size. Incidence of amenorrhea was significantly decreased in M group 20% than D group 75%, I group ,65%, N group 70% and there was an insignificant difference among other three groups. Continuation rate was significantly increased in M group than other three groups after 3 months and 6 months
Mirena had low systemic absorption of exogenous progesterone so, it had low effect on endogenous progesterone and ovulation rate with low incidence of side effects compared to other contraceptives containing progesterone. Therefore, Mirena is an effective and safe method as contraceptive and can be used with women who had complication with using progesterone containing contraceptive methods in the study.