To describe the detailed clinical characteristics and outcomes of patients with Streptococcus suis (S. suis) meningitis in Liuzhou, China.We described the chief clinical manifestations, auxiliary examination results, treatment strategies,treatment efficacy, and follow-up results of 17 consecutive patients with S. suis meningitis, to improve the diagnosis and reduce the misdiagnosis of S. suis meningitis. The study included 17 patients of S. suis meningitis. The most common clinical presentations were fever (88.2%), sensorineural hearing loss (76.47%), headache (64.70%) , and altered mental status (47.06%). 64.71% had residual symptoms of sensorineural hearing loss at discharge, and moderate disabilities occurred in 68.75% of patients in the form of sensorineural deafness (11 patients) and hemiparesis (1 patients). Metagenomic analysis using next generation sequencing of cerebrospinal fluid (CSF) were S.suis in 9 patients. After 6-month follow-up, the average modified Rankin Scale (mRS) and Activities of Daily Living (ADL) score at follow-up was significantly better than that at admission (P < 0.05). The clinical characteristics of S. suis meningitis were fever, headache, altered mental status and sensorineural hearing loss. Early antibiotic drugs are crucial for the treatment of sensorineural hearing loss. Clinicians should improve the diagnosis and treatment of S. suis meningitis and prevent misdiagnosis or non-diagnosis. Early CSF culture or metagenomic analysis is effective, and most of the patients in our study had favorable outcomes.