All that lives will die. Our cells are the building blocks of life, and regulated, or programmed, cell death is a critical ubiquitous process. Without it our tissues would be unable to stay balanced. In spontaneous cell death, necrosis, the cell suddenly ruptures and damages those around it. However, the disruption of regulated cell death plays key roles in many human diseases. Particularly neurodegenerative diseases, which often include widespread death of neurons. A recent review paper highlights five major types of regulated cell death. The first type, apoptosis, is classic programmed cell death, which is organized and largely immune silent. Then pyroptosis, a highly inflammatory form of cell death where the cell membrane ruptures. Autophagy-dependent cell death ramps up the cellular process autophagy, which recycles cellular components into usable metabolites. Necroptosis is a very necrosis-like type of cell death, but unlike true necrosis it is regulated rather than spontaneous. Lastly, ferroptosis is a unique iron-dependent form of regulated cell death where iron accumulates in the cell. Each cell death type is typically researched in isolation, but there is growing evidence that they interact. Understanding the regulation and interaction of these lethal subroutines could lead to new therapies for excessive cell death or growth.