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Original Article – Cancer Research
Yanzi Qin
Department of Pathology, the First Affiliated Hospital of Bengbu Medical University, Bengbu Medical College, Changhuai Road 287#, Bengbu, Anhui 233000, People’s Republic of China
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4241-9638
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study to explore the relationships between SOX4, SOX17, vascular endothelial (VE)-cadherin and VM with the occurrence and development of ESCC.
Methods: SOX4, SOX17, and VE-cadherin expression as well as VM in tissues were determined by immunohistochemistry (IHC). The cell invasion, migration, and proliferation were determined after silencing of VE-cadherin. SOX4, SOX17, and VE-cadherin protein and mRNA expression were quantified by Western blotting and qRT-PCR analyses, respectively.
Results: The expression of SOX17, SOX4, and VE-cadherin were significantly correlated with clinical characteristics of ESCC. After VE-cadherin silencing, the cell invasion, migration, and proliferation were decreased, while SOX17 levels were increased and SOX4 levels were decreased.
Conclusions: SOX17, SOX4, and VE-cadherin are involved in the development of ESCC.
Keywords
esophageal cancer, squamous cell carcinoma, SOX17, SOX4, VE-cadherin, vasculogenic mimicry
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Original Article – Cancer Research
Yanzi Qin
Department of Pathology, the First Affiliated Hospital of Bengbu Medical University, Bengbu Medical College, Changhuai Road 287#, Bengbu, Anhui 233000, People’s Republic of China
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4241-9638
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 2
Posted 07 Feb, 2021
No community comments so far
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study to explore the relationships between SOX4, SOX17, vascular endothelial (VE)-cadherin and VM with the occurrence and development of ESCC.
Methods: SOX4, SOX17, and VE-cadherin expression as well as VM in tissues were determined by immunohistochemistry (IHC). The cell invasion, migration, and proliferation were determined after silencing of VE-cadherin. SOX4, SOX17, and VE-cadherin protein and mRNA expression were quantified by Western blotting and qRT-PCR analyses, respectively.
Results: The expression of SOX17, SOX4, and VE-cadherin were significantly correlated with clinical characteristics of ESCC. After VE-cadherin silencing, the cell invasion, migration, and proliferation were decreased, while SOX17 levels were increased and SOX4 levels were decreased.
Conclusions: SOX17, SOX4, and VE-cadherin are involved in the development of ESCC.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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