Glioblastoma multiforme (GBM) is a deadly brain cancer that affects both adults and children. GBM remains mostly incurable because of the nonuniform nature of GBM cells and the numerous mechanisms involved. However, noncoding RNA molecules called circular RNAs (circRNAs) may be valuable targets for GBM treatment, because these molecules can promote or suppress cancer-related processes like cell proliferation, cell death, invasion, and chemoresistance. For example, various circRNAs can regulate pathways that are dysregulated in GBM, such as the PI3K/Akt/mTOR, Wnt/β-catenin, and MAPK pathways. Other circRNAs can positively or negatively regulate tumor blood supply establishment and metastasis to influence GBM progression. CircRNAs are stable and present in numerous body fluids, and some are associated with tumor grade and outcomes, making them promising biomarkers. In addition, silencing or overexpressing certain circRNAs in patients may help treat GBM or improve patients’ responses to other treatments. Notably, much less is known about circRNAs than about other small RNA molecules like mRNAs, so more research is needed. Nevertheless, the current evidence provides hope that circRNAs will be useful tools for GBM diagnosis and treatment to help eradicate this life-threatening disease.