Ethical Approval and Consent to participate
The study was conducted according to the guidelines laid down in the Declaration of Helsinki, and approval for the study was obtained from the Ethics Committee of Zhujiang Hospital, Southern Medical University (reference number: 2021-KY-038-02). Informed consent has been obtained for utilizing samples for research, with prior approval by the clinical Biobank Centre at Zhujiang Hospital of Southern Medical University (approval number 2020-YBK-001-02).
Consent for Publication
All authors have read and given consent for publication.
Additional data to that included in the manuscript can be provided under request.
The authors declare that they have no competing interests.
This work was supported by the National Natural Science Foundation of China (81974178, 81974177), Guangdong Basic and Applied Basic Research Foundation (2020A1515010038) and the Presidential Foundation of Zhujiang Hospital of Southern Medical University (No. yzjj2018rc03).
HS and CD jointly conceptualized the study. HS and KS designed experiments and prepared the manuscript. ZS provided expertise and participated in the design of the experiments. XZ, XL, XL, SS, WC, YL, NZ, YX, DC, WL and XH collected the patient samples and information. ZS, KS, HS, QN, MZ, HT, CW, YC and FX analyzed the data. HS, ZS, CD and ZZ revised the manuscript. All authors read and approved the final manuscript.
We would like to thank Dr. Zhen Liu for technical assistance. We would also like to thank all staff at the Neurosurgery Centre and Cerebrovascular Surgery of Zhujiang Hospital of Southern Medical University, and the technical staff of the Clinical Biobank Centre for their kind assistance. We would also like to thank all staff at clinical Research Centre of Zhujiang Hospital for their support in overseeing the study. Finally, we thank all tissue donors and their families who have kindly donated their resected specimens to the Clinical Biobank Centre.
Kaijian Sun, Xin Zhang and Xin Li have contributed equally to this work and share first authorship.
Neurosurgery Center, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, The National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong, China.
Kaijian Sun, Xin Zhang, Xifeng Li, Shixing Su, Hao Tian, Meiqin Zeng, Cheng Wang, Nan Zhang, Ying Cao, Wenchao Liu, Xuying He, Chuanzhi Duan, Haitao Sun
Clinical Biobank Centre, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong, China.
Xin Li2, Yunhao Luo, Yugu Xie, Fangbo Xia, Haitao Sun
Clinical Research Centre, Orthopedic Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Wuhan Metware Biotechnology Co., Ltd., Wuhan 430000, China.
State Key Laboratory of Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730000, China.
Key Laboratory of Mental Health of the Ministry of Education, Guangdong–Hong Kong–Macao Greater Bay Area Centre for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou 510515, Guangdong, China.
Correspondence to Zunji Shi, Chuanzhi Duan and Haitao Sun.