Ras is a key signaling protein that controls cell fates, including proliferation, differentiation, migration, and apoptosis, and Ras effectors are proteins that influence Ras-regulated signaling pathways. Because mutations in Ras have been found to play a key role in cancer initiation and progression, scientists hope that obtaining a clearer understanding of Ras–Ras effector interactions will improve the development of effective cancer treatments. To meet this need, a team of researchers recently constructed a comprehensive Ras–Ras effector network with information obtained from public pathway and protein interaction databases. The network was composed of 2290 proteins, including 12 classes of Ras effectors, connected through 19,080 protein–protein interactions, with an increasing number of interactions occurring in each layer of the 3-layer signaling network. The team also identified a high level of crosstalk among the proteins of the 12 considered effector classes and showed that 42% of the identified processes provide novel insights into the unexplored functions of Ras effector pathways. While this generalized network requires further refinements to be applicable to specific cell types and tissues, it represents a critical stepping stone in the definition of Ras–Ras effector networks and their potential manipulation as a therapeutic strategy.