See the published version of this preprint at Antimicrobial Resistance & Infection Control.
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Research
Chris Kenyon
Instituut voor Tropische Geneeskunde
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2557-8998
License:
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Background
It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae .
Methods
We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-level prevalence of gonococcal AMR in 30 European countries predicts homologous AMR in other bacteria. The data used was from the European Antimicrobial Resistance Surveillance Network.
Results
The prevalence of gonococcal ciprofloxacin resistance was found to be positively associated with AMR prevalence in E. coli (coef. 0.52; P=0.007), Acinetobacter spp . (coef. 0.13; P=0.044) and P. aeruginosa (coef. 0.36; P=0.020) but not K. pneumoniae .
Azithromycin resistance in N. gonorrhoeae was positively associated with macrolide resistance in S. pneumoniae (coef. 0.01; P=0.018). No association was found for cephalosporins.
Conclusions
Gonococcal AMR is linked to that in other bacteria. This finding is likely explained by high antimicrobial consumption in affected populations and provides additional motivation for strengthening antimicrobial stewardship programs.
Keywords
Gonorrhoea, Neisseria gonorrhoeae, macrolides, fluoroquinolones, macrolides, antimicrobial resistance, stewardship, antibiotic consumption, bystander selection
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CURRENT STATUS: Published
View the published article at Antimicrobial Resistance & Infection Control.
Version 1
Posted 11 Mar, 2020
No community comments so far
Editorial decision: Minor revision
On 09 Jun, 2020
Review #2 received
Received 05 Jun, 2020
Reviewer #1 agreed
On 11 May, 2020
Reviewer #2 agreed
On 11 May, 2020
Review #1 received
Received 11 May, 2020
Reviewers invited
Invitations sent on 04 May, 2020
Editor assigned
On 10 Mar, 2020
Editor invited
On 09 Mar, 2020
Submission checks complete
On 06 Mar, 2020
First submitted
On 04 Mar, 2020
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Antimicrobial Resistance & Infection Control.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Chris Kenyon
Instituut voor Tropische Geneeskunde
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2557-8998
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Antimicrobial Resistance & Infection Control.
Version 1
Posted 11 Mar, 2020
No community comments so far
Editorial decision: Minor revision
On 09 Jun, 2020
Review #2 received
Received 05 Jun, 2020
Reviewer #1 agreed
On 11 May, 2020
Reviewer #2 agreed
On 11 May, 2020
Review #1 received
Received 11 May, 2020
Reviewers invited
Invitations sent on 04 May, 2020
Editor assigned
On 10 Mar, 2020
Editor invited
On 09 Mar, 2020
Submission checks complete
On 06 Mar, 2020
First submitted
On 04 Mar, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Antimicrobial Resistance & Infection Control.
Background
It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae .
Methods
We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-level prevalence of gonococcal AMR in 30 European countries predicts homologous AMR in other bacteria. The data used was from the European Antimicrobial Resistance Surveillance Network.
Results
The prevalence of gonococcal ciprofloxacin resistance was found to be positively associated with AMR prevalence in E. coli (coef. 0.52; P=0.007), Acinetobacter spp . (coef. 0.13; P=0.044) and P. aeruginosa (coef. 0.36; P=0.020) but not K. pneumoniae .
Azithromycin resistance in N. gonorrhoeae was positively associated with macrolide resistance in S. pneumoniae (coef. 0.01; P=0.018). No association was found for cephalosporins.
Conclusions
Gonococcal AMR is linked to that in other bacteria. This finding is likely explained by high antimicrobial consumption in affected populations and provides additional motivation for strengthening antimicrobial stewardship programs.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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