This preprint is under consideration at Journal of Translational Medicine. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Bing He
Shengjing Hospital of China Medical University,No. 36 Sanhao Street,Heping District, Shenyang City, Liaoning Province, China
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9694-6591
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Time-restricted feeding (TRF) is a form of intermittent fasting, which is beneficial for weight loss and cardiometabolic health. Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine and metabolic diseases affecting women of childbearing age. It is associated with an increased prevalence of metabolic syndrome, cardiovascular disease and type 2 diabetes. While limited data are available on the effects of TRF in PCOS. Thus, we sought to investigate the effects of TRF in women with anovulatory PCOS.
Methods: Eighteen women aged between 18 and 31 with anovulation of PCOS participated in a 6-week trial and were divided into two consecutive periods: (1) 1-week baseline period; and (2) 5-week TRF period. Fifteen participants completed the study. Changes in body weight, body mass index (BMI), Waist-to-Hip Ratio, skeletal muscle mass, body fat mass (BFM), body fat percentage (BF%), visceral fat area (VFA), luteinizing hormone (LH), follicle-stimulating hormone (FSH), LH/FSH, total testosterone (TT), sex hormone-binding globulin (SHBG), free androgen index (FAI), fasting glucose, fasting insulin (FINS), homeostasis model assessment-insulin resistance (HOMA-IR), area under the curve (AUC) for insulin (AUCInsulin), area under the curve (AUC) for glucose (AUCGlucose), AUCInsulin/AUCGlucose Ratio, lipids, uric acid, alanine aminotransferase (ALT), aspartate aminotransferase, high-sensitivity C-reactive protein (hsCRP), insulin-like growth factor (IGF-1), menstrual cycle and eating behaviors were evaluated.
Results: Significant changes in body weight, BMI, BFM, BF%, VFA, TT, SHBG, FAI, FINS, HOMA-IR, AUCInsulin, AUCInsulin/AUCGlucose Ratio, ALT, hsCRP and IGF-1 were found after the TRF period. An improvement in menstrual cycle irregularity was detected in 73.3% (11/15) patients.
Conclusion: The diet of TRF may be beneficial to anovulatory PCOS on weight loss (especially reducing body fat), improving menstruation, hyperandrogenemia, insulin resistance and inflammation.
Trial registration Clinicaltrial.gov, NCT04580433, registrered October 8, 2020, https://clinicaltrials.gov/ct2/show/NCT04580433
Keywords
intermittent fasting, time-restricted feeding, polycystic ovary syndrome, weight-loss, insulin resistance, hyperandrogenemia, anovulation
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This preprint is under consideration at Journal of Translational Medicine. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Bing He
Shengjing Hospital of China Medical University,No. 36 Sanhao Street,Heping District, Shenyang City, Liaoning Province, China
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9694-6591
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 04 Feb, 2021
No community comments so far
Reviewer #4 agreed
On 18 Feb, 2021
Review #1 received
Received 14 Feb, 2021
Reviewer #2 agreed
On 31 Jan, 2021
Reviewer #3 agreed
On 31 Jan, 2021
Reviewers invited
Invitations sent on 31 Jan, 2021
Reviews received
Received 31 Jan, 2021
Reviewer #1 agreed
On 31 Jan, 2021
Editor assigned
On 28 Jan, 2021
Editor invited
On 28 Jan, 2021
Submission checks complete
On 28 Jan, 2021
First submitted
On 27 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Translational Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Time-restricted feeding (TRF) is a form of intermittent fasting, which is beneficial for weight loss and cardiometabolic health. Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine and metabolic diseases affecting women of childbearing age. It is associated with an increased prevalence of metabolic syndrome, cardiovascular disease and type 2 diabetes. While limited data are available on the effects of TRF in PCOS. Thus, we sought to investigate the effects of TRF in women with anovulatory PCOS.
Methods: Eighteen women aged between 18 and 31 with anovulation of PCOS participated in a 6-week trial and were divided into two consecutive periods: (1) 1-week baseline period; and (2) 5-week TRF period. Fifteen participants completed the study. Changes in body weight, body mass index (BMI), Waist-to-Hip Ratio, skeletal muscle mass, body fat mass (BFM), body fat percentage (BF%), visceral fat area (VFA), luteinizing hormone (LH), follicle-stimulating hormone (FSH), LH/FSH, total testosterone (TT), sex hormone-binding globulin (SHBG), free androgen index (FAI), fasting glucose, fasting insulin (FINS), homeostasis model assessment-insulin resistance (HOMA-IR), area under the curve (AUC) for insulin (AUCInsulin), area under the curve (AUC) for glucose (AUCGlucose), AUCInsulin/AUCGlucose Ratio, lipids, uric acid, alanine aminotransferase (ALT), aspartate aminotransferase, high-sensitivity C-reactive protein (hsCRP), insulin-like growth factor (IGF-1), menstrual cycle and eating behaviors were evaluated.
Results: Significant changes in body weight, BMI, BFM, BF%, VFA, TT, SHBG, FAI, FINS, HOMA-IR, AUCInsulin, AUCInsulin/AUCGlucose Ratio, ALT, hsCRP and IGF-1 were found after the TRF period. An improvement in menstrual cycle irregularity was detected in 73.3% (11/15) patients.
Conclusion: The diet of TRF may be beneficial to anovulatory PCOS on weight loss (especially reducing body fat), improving menstruation, hyperandrogenemia, insulin resistance and inflammation.
Trial registration Clinicaltrial.gov, NCT04580433, registrered October 8, 2020, https://clinicaltrials.gov/ct2/show/NCT04580433
Figure 1
Figure 2
Figure 3
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