Reduced flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI
Background : Acute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI. Methods : 4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66±12yo; prospectively acquired in 2016-2017) and 19 healthy volunteers (10 males; 40±16yo; retrospective from 2010-2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates. Results : Peak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P=0.01) and apex (fitted reduction = 1.4 L/min; P=0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P=0.01). Conclusions : A regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced regional flow relative to controls.
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Posted 03 Jan, 2020
On 30 Dec, 2019
On 18 Dec, 2019
On 18 Dec, 2019
On 16 Dec, 2019
Received 10 Dec, 2019
On 02 Dec, 2019
Received 02 Dec, 2019
On 27 Nov, 2019
Invitations sent on 27 Nov, 2019
On 14 Nov, 2019
On 13 Nov, 2019
On 13 Nov, 2019
On 07 Oct, 2019
Received 04 Oct, 2019
On 20 Sep, 2019
Received 02 Sep, 2019
On 05 Aug, 2019
Invitations sent on 03 Aug, 2019
On 25 Jun, 2019
On 24 Jun, 2019
On 24 Jun, 2019
On 20 Jun, 2019
Reduced flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI
Posted 03 Jan, 2020
On 30 Dec, 2019
On 18 Dec, 2019
On 18 Dec, 2019
On 16 Dec, 2019
Received 10 Dec, 2019
On 02 Dec, 2019
Received 02 Dec, 2019
On 27 Nov, 2019
Invitations sent on 27 Nov, 2019
On 14 Nov, 2019
On 13 Nov, 2019
On 13 Nov, 2019
On 07 Oct, 2019
Received 04 Oct, 2019
On 20 Sep, 2019
Received 02 Sep, 2019
On 05 Aug, 2019
Invitations sent on 03 Aug, 2019
On 25 Jun, 2019
On 24 Jun, 2019
On 24 Jun, 2019
On 20 Jun, 2019
Background : Acute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI. Methods : 4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66±12yo; prospectively acquired in 2016-2017) and 19 healthy volunteers (10 males; 40±16yo; retrospective from 2010-2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates. Results : Peak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P=0.01) and apex (fitted reduction = 1.4 L/min; P=0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P=0.01). Conclusions : A regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced regional flow relative to controls.
Figure 1
Figure 2
Figure 3
Figure 4