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Reduced flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI
Philip A Corrado
University of Wisconsin Madison
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1510-8247
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Medical Imaging.
Background : Acute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI. Methods : 4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66±12yo; prospectively acquired in 2016-2017) and 19 healthy volunteers (10 males; 40±16yo; retrospective from 2010-2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates. Results : Peak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P=0.01) and apex (fitted reduction = 1.4 L/min; P=0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P=0.01). Conclusions : A regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced regional flow relative to controls.
Keywords
Phase contrast; 4D flow; myocardial infarction; left ventricle
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CURRENT STATUS: Published
Version 3
Posted 03 Jan, 2020
Published
On 30 Dec, 2019
No community comments so far
Submission checks complete
On 18 Dec, 2019
Editorial decision: Accept
On 18 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 16 Dec, 2019
Review #1 received
Received 10 Dec, 2019
Reviewer #2 agreed
On 02 Dec, 2019
Review #2 received
Received 02 Dec, 2019
Reviewer #1 agreed
On 27 Nov, 2019
Reviewers invited
Invitations sent on 27 Nov, 2019
Editor assigned
On 14 Nov, 2019
Submission checks complete
On 13 Nov, 2019
Editor invited
On 13 Nov, 2019
No comments provided
Editorial decision: Major revision
On 07 Oct, 2019
Review #2 received
Received 04 Oct, 2019
Reviewer #2 agreed
On 20 Sep, 2019
Review #1 received
Received 02 Sep, 2019
Reviewer #1 agreed
On 05 Aug, 2019
Reviewers invited
Invitations sent on 03 Aug, 2019
Submission checks complete
On 25 Jun, 2019
Editor invited
On 24 Jun, 2019
Editor assigned
On 24 Jun, 2019
First submitted
On 20 Jun, 2019
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Subject Areas
Nuclear Medicine & Medical Imaging
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This preprint is under consideration at BMC Medical Imaging. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Reduced flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI
Philip A Corrado
University of Wisconsin Madison
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1510-8247
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 03 Jan, 2020
Published
On 30 Dec, 2019
No community comments so far
Submission checks complete
On 18 Dec, 2019
Editorial decision: Accept
On 18 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 16 Dec, 2019
Review #1 received
Received 10 Dec, 2019
Reviewer #2 agreed
On 02 Dec, 2019
Review #2 received
Received 02 Dec, 2019
Reviewer #1 agreed
On 27 Nov, 2019
Reviewers invited
Invitations sent on 27 Nov, 2019
Editor assigned
On 14 Nov, 2019
Submission checks complete
On 13 Nov, 2019
Editor invited
On 13 Nov, 2019
No comments provided
Editorial decision: Major revision
On 07 Oct, 2019
Review #2 received
Received 04 Oct, 2019
Reviewer #2 agreed
On 20 Sep, 2019
Review #1 received
Received 02 Sep, 2019
Reviewer #1 agreed
On 05 Aug, 2019
Reviewers invited
Invitations sent on 03 Aug, 2019
Submission checks complete
On 25 Jun, 2019
Editor invited
On 24 Jun, 2019
Editor assigned
On 24 Jun, 2019
First submitted
On 20 Jun, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nuclear Medicine & Medical Imaging
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Medical Imaging.
Background : Acute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI. Methods : 4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66±12yo; prospectively acquired in 2016-2017) and 19 healthy volunteers (10 males; 40±16yo; retrospective from 2010-2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates. Results : Peak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P=0.01) and apex (fitted reduction = 1.4 L/min; P=0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P=0.01). Conclusions : A regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced regional flow relative to controls.
Figure 1
Figure 2
Figure 3
Figure 4