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Jianguo Shao
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3494-1533
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Background:To analyze the correlation between hepatic fibrosis and fat indexes in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus(T2DM).
Method: Data of 135 NAFLD patients treated in the outpatient and inpatient department of gastroenterology of the Nantong Third People's Hospital Affiliated to Nantong University from January 2016 to December 2019 were collected and analyzed. The patients were divided into NAFLD group and NAFLD+T2DM group according to medical history, biochemical indexes and B-ultrasound examination results. The fat content and fibrosis degree were detected by FibroTouch instantaneous elastography. Risk factors and protective factors for hepatic fibrosis index were analyzed statistically.
Results: (1) Age, fibrosis index, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, body mass Index(BMI), low density lipoprotein(LDL), hemoglobin A1c(HbA1c) and C-reactive protein (CRP) levels in NAFLD + T2DM group were significantly higher than those in NAFLD group ( P <0.01, Table 1). HDL and peptide C in NAFLD + T2DM group were lower than those in NAFLD group. Step-by-step logistic regression suggested that ALT and LDLC were risk factors, and fibrosis index and peptide C were protective factors. (2）In NAFLD+T2DM group, HDLC and peptide C in the fibrosis subgroup were significantly decreased than compared with those in the non-fibrosis subgroup, and the creatinine, LDLC, HbA1C , Uric acid and BMI in the fibrosis subgroup were significantly increased compared with the non-fibrosis subgroup.（3）Linear regression analysis indicated that HDLC and HbA1C were risk factors and peptide C was protective factor.
Conclusion: Hepatic fibrosis is involved in the pathophysiological process of NAFLD and T2DM, and it is extreme importance to prevent hepatic fibrosis.
Keywords
Non-alcoholic fatty liver disease(NAFLD), type 2 diabetes mellitus (T2DM), hepatic fibrosis index
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Jianguo Shao
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3494-1533
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 12 Mar, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:To analyze the correlation between hepatic fibrosis and fat indexes in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus(T2DM).
Method: Data of 135 NAFLD patients treated in the outpatient and inpatient department of gastroenterology of the Nantong Third People's Hospital Affiliated to Nantong University from January 2016 to December 2019 were collected and analyzed. The patients were divided into NAFLD group and NAFLD+T2DM group according to medical history, biochemical indexes and B-ultrasound examination results. The fat content and fibrosis degree were detected by FibroTouch instantaneous elastography. Risk factors and protective factors for hepatic fibrosis index were analyzed statistically.
Results: (1) Age, fibrosis index, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, body mass Index(BMI), low density lipoprotein(LDL), hemoglobin A1c(HbA1c) and C-reactive protein (CRP) levels in NAFLD + T2DM group were significantly higher than those in NAFLD group ( P <0.01, Table 1). HDL and peptide C in NAFLD + T2DM group were lower than those in NAFLD group. Step-by-step logistic regression suggested that ALT and LDLC were risk factors, and fibrosis index and peptide C were protective factors. (2）In NAFLD+T2DM group, HDLC and peptide C in the fibrosis subgroup were significantly decreased than compared with those in the non-fibrosis subgroup, and the creatinine, LDLC, HbA1C , Uric acid and BMI in the fibrosis subgroup were significantly increased compared with the non-fibrosis subgroup.（3）Linear regression analysis indicated that HDLC and HbA1C were risk factors and peptide C was protective factor.
Conclusion: Hepatic fibrosis is involved in the pathophysiological process of NAFLD and T2DM, and it is extreme importance to prevent hepatic fibrosis.
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