This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Original Article
Ayşem Yurtseven Günay
Istanbul University: Istanbul Universitesi
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1161-1005
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
Nerve injuries formed during oral and maxillofacial surgical operations occur usually by crush or tension-type damages rather than incisions or ruptures. Such nerve injuries can be treated by providing regeneration with pharmacological agents without surgical intervention. The aim of this study was to determine and compare the effects of dexamethasone, B vitamin complex, and nerve growth factor on peripheral nerve regeneration with a local application on the inferior alveolar nerve.
Methods
Twenty-four Wistar Albino rats weighing 220-250 grams were used in the study. Experimental animals were divided into 4 groups. According to the groups, animals were treated with saline, dexamethasone, vitamin B complex and nerve growth factor. All animals were sacrificed on the 21st day and inferior alveolar nerves were resected for microscopic examination.
Results
The integrity and irregularities of myelin sheaths and vacuole formation were evaluated under a light microscope. Statistical analysis was performed with SPSS version 17.0. When histopathological findings were evaluated, it was observed that dexamethasone and vitamin B application triggered regeneration. However, regeneration in the group treated with nerve growth factor was much more obvious.
Conclusions
Local drug applications are beneficial for regeneration in inferior alveolar nerve injury. Considering their success, studies are needed to place growth factors in clinical practice.
Keywords
Mandibular nerve injury, Dexamethasone, Vitamin b complex, Nerve growth factor
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Original Article
Ayşem Yurtseven Günay
Istanbul University: Istanbul Universitesi
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1161-1005
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 05 Feb, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
Nerve injuries formed during oral and maxillofacial surgical operations occur usually by crush or tension-type damages rather than incisions or ruptures. Such nerve injuries can be treated by providing regeneration with pharmacological agents without surgical intervention. The aim of this study was to determine and compare the effects of dexamethasone, B vitamin complex, and nerve growth factor on peripheral nerve regeneration with a local application on the inferior alveolar nerve.
Methods
Twenty-four Wistar Albino rats weighing 220-250 grams were used in the study. Experimental animals were divided into 4 groups. According to the groups, animals were treated with saline, dexamethasone, vitamin B complex and nerve growth factor. All animals were sacrificed on the 21st day and inferior alveolar nerves were resected for microscopic examination.
Results
The integrity and irregularities of myelin sheaths and vacuole formation were evaluated under a light microscope. Statistical analysis was performed with SPSS version 17.0. When histopathological findings were evaluated, it was observed that dexamethasone and vitamin B application triggered regeneration. However, regeneration in the group treated with nerve growth factor was much more obvious.
Conclusions
Local drug applications are beneficial for regeneration in inferior alveolar nerve injury. Considering their success, studies are needed to place growth factors in clinical practice.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
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