This preprint is under consideration at Sports Medicine-Open. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Original Research Article
Anne Ribeiro Streb
Universidade Federal de Santa Catarina
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9195-4210
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
The aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity.
Methods
Was conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9kg/m²): control group (CG, n=23), non-periodized group (NG, n=23), and linear periodized group (PG, n=23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50%–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2×10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2×12–14 to 2×8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations.
Results
After 16 weeks of training, per protocol analysis (n=39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p=0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p=0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p=0.002).
Conclusion
Periodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity.
Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019 - https://ensaiosclinicos.gov.br/trial/5970/1
Keywords
Chronic Disease, Insulin Resistance, Adult, Exercise, Clinical Trial
Figure 1
Figure 2
Figure 3
Figure 4
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 08 Feb, 2021
No community comments so far
Editorial decision: Major Revision
On 16 Jun, 2021
Review #2 received
Received 25 May, 2021
Reviewer #2 agreed
On 04 May, 2021
Reviews received
Received 04 May, 2021
Review #1 received
Received 03 May, 2021
Reviewer #1 agreed
On 12 Apr, 2021
Reviewers invited
Invitations sent on 06 Apr, 2021
Editor assigned
On 30 Jan, 2021
Submission checks complete
On 30 Jan, 2021
Editor invited
On 30 Jan, 2021
First submitted
On 27 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Sports Medicine-Open. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Original Research Article
Anne Ribeiro Streb
Universidade Federal de Santa Catarina
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9195-4210
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 08 Feb, 2021
No community comments so far
Editorial decision: Major Revision
On 16 Jun, 2021
Review #2 received
Received 25 May, 2021
Reviewer #2 agreed
On 04 May, 2021
Reviews received
Received 04 May, 2021
Review #1 received
Received 03 May, 2021
Reviewer #1 agreed
On 12 Apr, 2021
Reviewers invited
Invitations sent on 06 Apr, 2021
Editor assigned
On 30 Jan, 2021
Submission checks complete
On 30 Jan, 2021
Editor invited
On 30 Jan, 2021
First submitted
On 27 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
The aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity.
Methods
Was conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9kg/m²): control group (CG, n=23), non-periodized group (NG, n=23), and linear periodized group (PG, n=23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50%–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2×10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2×12–14 to 2×8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations.
Results
After 16 weeks of training, per protocol analysis (n=39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p=0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p=0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p=0.002).
Conclusion
Periodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity.
Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019 - https://ensaiosclinicos.gov.br/trial/5970/1
Figure 1
Figure 2
Figure 3
Figure 4
Loading...