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Research article
Milad Azami
Ilam University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4509-5520
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction : Gastroesophageal reflux disease (GERD), which leads to acid reflux into the esophagus, is a common gastrointestinal disorder. Several studies have shown the prevalence of GERD in Iranian population, but their evidence is contradictory. Therefore, the present study was conducted to investigate the epidemiology of GERD in Iran.
Methods: The entire steps of this systematic review and meta-analysis were based on the MOOSE protocol, and the results were accordance with the PRISMA guideline. To find potentially relevant published articles, comprehensive search was done on international online databases Scopus, Science Direct, EMBASE, PubMed/Medline, CINAHL, EBSCO, Cochrane Library (Cochrane Database of Systematic Reviews - CDSR), Web of Science (ISI) and Iranian online databases IranDoc, (SID), Magiran, RICST, Iranian National Library, and Barakat Knowledge Network System and the Google Scholar search engine in June 2019. Cochran test and I 2 index were used to assess the heterogeneity of the studies. Data were analyzed using Comprehensive Meta-Analysis (CMA) software.
Results: The daily, weekly, monthly, and overall prevalence of GERD symptoms in Iranian population was 5.64% (95%CI [confidence interval]: 3.77%-8.35%; N=66,398), 12.50% (95%CI: 9.63%-16.08%; N=110,388), 18.62% (95%CI: 12.90%-26.12%; N= 70,749) and 43.07% (95%CI: 35.00%-51.53%; N=73,189), respectively. The daily, weekly, monthly, and overall prevalence of heartburn in Iranian population was 2.46% (95%CI: 0.93%-6.39%; N=18,774), 9.52% (95%CI: 6.16%-14.41%; N=54,125), 8.19% (95%CI: 2.42%-24.30%; N=19,363) and 23.20% (95%CI: 13.56%-36.79%; N=26,543), respectively. The daily, weekly, monthly, and overall prevalence of regurgitation in Iranian population was 4.00% (95%CI: 1.88%-8.32%; N=18,774), 9.79% (95%CI: 5.99%-15.60%; N=41,140), 13.76% (95%CI: 6.18%-44.31%; N=19,363) and 36.53% (95%CI: 19.30%-58.08%; N=21,174), respectively.
Conclusion: The present meta-analysis provides comprehensive and useful information on the epidemiology of GERD in Iran for policy-makers and health care providers. This study showed a high prevalence of GERD in Iran. Therefore, effective measures on GERD-related factors such as lifestyle can be among the health policies of Iran.
Keywords
Epidemiology, Gastroesophageal Reflux Disease, Iran, Meta-analysis
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View the published article at BMC Gastroenterology.
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On 31 May, 2020
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On 04 May, 2020
Review #1 received
Received 23 Apr, 2020
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Reviewer #1 agreed
On 20 Mar, 2020
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On 08 Mar, 2020
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Subject Areas
Gastroenterology & Hepatology
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See the published version of this preprint at BMC Gastroenterology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Milad Azami
Ilam University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4509-5520
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
Version 1
Posted 13 Mar, 2020
No community comments so far
Reviewer #3 agreed
On 31 May, 2020
Review #3 received
Received 31 May, 2020
Editorial decision: Major revision
On 31 May, 2020
Review #2 received
Received 29 May, 2020
Reviewer #2 agreed
On 04 May, 2020
Review #1 received
Received 23 Apr, 2020
Reviewers invited
Invitations sent on 20 Mar, 2020
Reviewer #1 agreed
On 20 Mar, 2020
Editor assigned
On 08 Mar, 2020
Submission checks complete
On 07 Mar, 2020
Editor invited
On 07 Mar, 2020
First submitted
On 04 Mar, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Gastroenterology.
Introduction : Gastroesophageal reflux disease (GERD), which leads to acid reflux into the esophagus, is a common gastrointestinal disorder. Several studies have shown the prevalence of GERD in Iranian population, but their evidence is contradictory. Therefore, the present study was conducted to investigate the epidemiology of GERD in Iran.
Methods: The entire steps of this systematic review and meta-analysis were based on the MOOSE protocol, and the results were accordance with the PRISMA guideline. To find potentially relevant published articles, comprehensive search was done on international online databases Scopus, Science Direct, EMBASE, PubMed/Medline, CINAHL, EBSCO, Cochrane Library (Cochrane Database of Systematic Reviews - CDSR), Web of Science (ISI) and Iranian online databases IranDoc, (SID), Magiran, RICST, Iranian National Library, and Barakat Knowledge Network System and the Google Scholar search engine in June 2019. Cochran test and I 2 index were used to assess the heterogeneity of the studies. Data were analyzed using Comprehensive Meta-Analysis (CMA) software.
Results: The daily, weekly, monthly, and overall prevalence of GERD symptoms in Iranian population was 5.64% (95%CI [confidence interval]: 3.77%-8.35%; N=66,398), 12.50% (95%CI: 9.63%-16.08%; N=110,388), 18.62% (95%CI: 12.90%-26.12%; N= 70,749) and 43.07% (95%CI: 35.00%-51.53%; N=73,189), respectively. The daily, weekly, monthly, and overall prevalence of heartburn in Iranian population was 2.46% (95%CI: 0.93%-6.39%; N=18,774), 9.52% (95%CI: 6.16%-14.41%; N=54,125), 8.19% (95%CI: 2.42%-24.30%; N=19,363) and 23.20% (95%CI: 13.56%-36.79%; N=26,543), respectively. The daily, weekly, monthly, and overall prevalence of regurgitation in Iranian population was 4.00% (95%CI: 1.88%-8.32%; N=18,774), 9.79% (95%CI: 5.99%-15.60%; N=41,140), 13.76% (95%CI: 6.18%-44.31%; N=19,363) and 36.53% (95%CI: 19.30%-58.08%; N=21,174), respectively.
Conclusion: The present meta-analysis provides comprehensive and useful information on the epidemiology of GERD in Iran for policy-makers and health care providers. This study showed a high prevalence of GERD in Iran. Therefore, effective measures on GERD-related factors such as lifestyle can be among the health policies of Iran.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
This is a list of supplementary files associated with this preprint. Click to download.
- Figure1suplementary.tif
- Figure7suplementary.tif
- Figure12suplementary.tif
- Figure3suplementary.tif
- Figure11suplementary.tif
- Figure10suplementary.tif
- Figure9suplementary.tif
- Figure8suplementary.tif
- Figure6suplementary.tif
- Figure2suplementary.tif
- Figure4suplementary.tif
- S1File.DOC
- Figure5suplementary.tif
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