1. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270, 26746–26749 (1995).
2. Ye R, Scherer PE. Adiponectin, driver or passenger on the road to insulin sensitivity? Mol Metab 2, 133–141 (2013).
3. Pajvani UB, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 278, 9073–9085 (2003).
4. Combs TP, et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 145, 367–383 (2004).
5. Qiao L, Zou C, van der Westhuyzen DR, Shao J. Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism. Diabetes 57, 1824–1833 (2008).
6. Asterholm IW, Scherer PE. Enhanced metabolic flexibility associated with elevated adiponectin levels. Am J Pathol 176, 1364–1376 (2010).
7. Kubota N, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277, 25863–25866 (2002).
8. Maeda N, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8, 731–737 (2002).
9. Li S, Shin HJ, Ding EL, van Dam RM. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 302, 179–188 (2009).
10. Arita Y, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257, 79–83 (1999).
11. Adamczak M, Wiecek A, Funahashi T, Chudek J, Kokot F, Matsuzawa Y. Decreased plasma adiponectin concentration in patients with essential hypertension. Am J Hypertens 16, 72–75 (2003).
12. Kizer JR, Barzilay JI, Kuller LH, Gottdiener JS. Adiponectin and risk of coronary heart disease in older men and women. J Clin Endocrinol Metab 93, 3357–3364 (2008).
13. Poehls J, et al. Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study. Diabetologia 52, 591–595 (2009).
14. Kim-Mitsuyama S, et al. Total adiponectin is associated with incident cardiovascular and renal events in treated hypertensive patients: subanalysis of the ATTEMPT-CVD randomized trial. Sci Rep 9, 16589 (2019).
15. Choi SH, et al. High serum adiponectin concentration and low body mass index are significantly associated with increased all-cause and cardiovascular mortality in an elderly cohort, "adiponectin paradox": the Korean Longitudinal Study on Health and Aging (KLoSHA). Int J Cardiol 183, 91–97 (2015).
16. Davey A, et al. Diabetes mellitus in centenarians. J Am Geriatr Soc 60, 468–473 (2012).
17. Arai Y, et al. Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians. EBioMedicine 2, 1549–1558 (2015).
18. Arai Y, Kamide K, Hirose N. Adipokines and Aging: Findings From Centenarians and the Very Old. Front Endocrinol (Lausanne) 10, 142 (2019).
19. Cnop M, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46, 459–469 (2003).
20. Muratsu J, et al. The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples. Front Endocrinol (Lausanne) 12, 805244 (2021).
21. Li N, et al. Adiponectin preserves metabolic fitness during aging. Elife 10, (2021).
22. Cohen KE, Katunaric B, SenthilKumar G, McIntosh JJ, Freed JK. Vascular endothelial adiponectin signaling across the life span. Am J Physiol Heart Circ Physiol 322, H57-H65 (2022).
23. Gondo Y, et al. Functional status of centenarians in Tokyo, Japan: developing better phenotypes of exceptional longevity. J Gerontol A Biol Sci Med Sci 61, 305–310 (2006).
24. Takayama M, et al. Morbidity of Tokyo-area centenarians and its relationship to functional status. J Gerontol A Biol Sci Med Sci 62, 774–782 (2007).
25. Arai Y, et al. Physical independence and mortality at the extreme limit of life span: supercentenarians study in Japan. J Gerontol A Biol Sci Med Sci 69, 486–494 (2014).
26. Arai Y, et al. The Tokyo Oldest Old survey on Total Health (TOOTH): a longitudinal cohort study of multidimensional components of health and well-being. BMC Geriatr 10, 35 (2010).
27. Arai Y, et al. Behavioral changes and hygiene practices of older adults in Japan during the first wave of COVID-19 emergency. BMC Geriatr 21, 137 (2021).
28. Sasaki T, Nishimoto Y, Hirata T, Abe Y, Takebayashi T, Arai Y. ALDH2 p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old. Genes (Basel) 12, (2021).
29. Dastani Z, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 8, e1002607 (2012).
30. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116, 1784–1792 (2006).
31. Lindsay RS, et al. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 360, 57–58 (2002).
32. Spranger J, et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 361, 226–228 (2003).
33. Falcone M, Blasi F, Menichetti F, Pea F, Violi F. Pneumonia in frail older patients: an up to date. Intern Emerg Med 7, 415–424 (2012).
34. Tabula Muris C. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature 583, 590–595 (2020).
35. Hirata T, et al. Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages. Nat Commun 11, 3820 (2020).
36. Sasaki T, et al. Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians. Sci Rep 11, 8539 (2021).
37. Purcell S, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81, 559–575 (2007).
38. Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190–2191 (2010).
39. Turner SD. qqman: an R package for visualizing GWAS results using Q-Q and manhattan plots. Journal of Open Source Software 3, 1–2 (2018).
40. Pruim RJ, et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 2336–2337 (2010).