Since the outbreak in late December 2019 in Wuhan, China, coronavirus disease-2019 (COVID-19) has become a global pandemic. We analyzed and compared the clinical, laboratory, and radiological characteristics between survivors and non-survivors and identify risk factors for mortality.
This single-center study was conducted at Hospital for COVID-19 patients in Kashan, Iran. Inpatients with confirmed COVID-19 were included. Clinical and laboratory variables, radiological features, complications were collected. Patients were classified as the discharged or survivor group and the death or non-survivor group based on their outcome (improvement or death). Clinical, Epidemiological characteristics, as well as laboratory parameters, were extracted from electronic medical records. Cox regression analysis was conducted to identify the risk factors for mortality. Significant level was set as 0.05 in all analyses.
Multiple Cox regression showed age (HR 1.028; 95% CI 1.016–1.039), LDH (HR 1.0004; 95% CI 1.0002–1.001), AST (HR 1.002; 95% CI 1.001–1.004) and BUN (HR 1.008; 95% CI 1.004–1.012) as factors associated with an increased risk of in-hospital mortality.
The current study showed that higher mortality was significantly associated with age, LDH, AST and BUN. Assessing risk factors of the disease could be helpful for clinicians to detect the risk of disease progression, to perform proper intervention earlier to get the best therapeutic outcome.