Literature acknowledges the critical role of self-construal in shaping entrepreneurial orientation and behaviour. While explanations for societal differences in entrepreneurial behaviours vary at organisational level, limited attention has been devoted to explaining the influence of self-construal on entrepreneurial orientation (EO) and growth of micro-enterprises. This study examined the influence of self-construal of micro-enterprise owners on their EO (risk-taking and innovativeness) and growth of their firms. Data collected using structured interviews administered on 80 micro-enterprise owners from Roma, Maseru, and Teya-Teyaneng in Lesotho were analysed using descriptive correlations, hierarchical regression analyses and partial least squares structural equation modeling (PLS-SEM). Findings show that the independent self-construal had positive and significant influence on the EO of micro-enterprises but the inter-dependent self-construal construct did not have a positive and significant effect on the EO. While independent self-construal negatively and significantly influenced enterprise growth, the interdependent self-construal did not have any influence on growth of micro-enterprises. the study recommends that universities and government departments such as Ministry of Small Business Development, Cooperatives and Marketing must provide entrepreneurial training to micro-enterprise owners on how to improve enterprise-oriented cultures and self-confidence in independent decision-making for the growth and survival of their enterprises.