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Research
Antoine El Asmar
Institut Jules Bordet
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6635-4616
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This work is licensed under a CC BY 4.0 License. Read Full License
Objective A retrospective study, handling the prognostic factors for bile leak and long term survival in 23 patients, with Hilar Cholangiocarcinoma, Bismuth Type III exclusively.
Methods Between 2010 and 2017, 23 patients underwent major hepatectomy for Type III Klatskin Tumor at our institution. 11 patients underwent hepatectomy for Type IIIB tumors, 10 patients underwent right hepatectomy for Type IIIA and 2 were omitted for loss of follow-up.
Results In 20 patients an R0 resection was achieved. Survival at 1, 3 and 5 years was respectively 78.3%, 61.9% and 38.1%. A BMI > 24 kg/m2 at presentation, was associated with a worse prognosis, at 1, 3 and 5 years, with statistical significance (p<0.05). A Creatinine > 0.74 at presentation, was associated with a decreased 5-year survival, with statistical significance (p<0.05).
Conclusion A BMI > 24 kg/m2, a Creatinine > 0.74, are factors of worse prognosis when present in a Type III Klatskin tumor patient. Age, sex, hemoglobin level, tumor size, cusa use, and the correlation of Type IIIB tumors with bile leakage, are all variables that showed borderline significance, and thus warrant further investigations in larger studies, using multicentric data.
Keywords
Klatskin's Tumor, Hilar Cholangiocarcinomas, Hepatectomies, Biliary Surgical Procedures
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Antoine El Asmar
Institut Jules Bordet
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6635-4616
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
View the published article at Clinical Oncology and Research.
Version 1
Posted 17 Mar, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Clinical Oncology and Research.
Objective A retrospective study, handling the prognostic factors for bile leak and long term survival in 23 patients, with Hilar Cholangiocarcinoma, Bismuth Type III exclusively.
Methods Between 2010 and 2017, 23 patients underwent major hepatectomy for Type III Klatskin Tumor at our institution. 11 patients underwent hepatectomy for Type IIIB tumors, 10 patients underwent right hepatectomy for Type IIIA and 2 were omitted for loss of follow-up.
Results In 20 patients an R0 resection was achieved. Survival at 1, 3 and 5 years was respectively 78.3%, 61.9% and 38.1%. A BMI > 24 kg/m2 at presentation, was associated with a worse prognosis, at 1, 3 and 5 years, with statistical significance (p<0.05). A Creatinine > 0.74 at presentation, was associated with a decreased 5-year survival, with statistical significance (p<0.05).
Conclusion A BMI > 24 kg/m2, a Creatinine > 0.74, are factors of worse prognosis when present in a Type III Klatskin tumor patient. Age, sex, hemoglobin level, tumor size, cusa use, and the correlation of Type IIIB tumors with bile leakage, are all variables that showed borderline significance, and thus warrant further investigations in larger studies, using multicentric data.
Figure 1
Figure 2
Figure 3
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