The North Pacific Oscillation (NPO), a primary atmospheric variability over the midlatitude, is a well-known trigger for ENSO events. Based on observational analyses, it has been suggested that the NPO-related wave activity flux (WAF) could directly induce the equatorial wind anomalies in both upper and lower levels. In this study, we further substantiate the impacts of the WAF on tropical circulations using climate models participating in the Coupled Model Intercomparison Project phases 5 and 6 (CMIP5/6). We found that the intensity of the southward WAF over the central Pacific is closely related to the simulated NPO–ENSO relation in the inter-model space. By classifying the models into two groups of strong and weak meridional WAF (MWAF), we reveal that the strong MWAF models simulate stronger upper- and lower-level equatorial winds and precipitation anomalies that facilitate the ENSO in subsequent winter. In addition, we demonstrate that the magnitude of the MWAF is closely related to the model’s climatological meridional wind and meridional shear of climatological zonal wind, emphasizing the role of systematic bias on the ENSO simulation.