This study presents a framework to delineate the potential fluoride contamination zones within the groundwater of the study area by employing GIS coupled with Multi-Criteria Decision Making-Analytical Hierarchy Process approach (MCDM-AHP). In this context, various groundwater contamination controlling hydrogeo-meteorological factors thematic layers were prepared in the GIS environment and assigned with an appropriate rating and weights. All the selected influencing factors were overlaid using a weighted overlaid index approach after normalizing the weights and ratings of the respective layers using the AHP technique and then computed the fluoride contamination zones (FCZs). The obtained results indicate that 61.50% (1101.82 km2) of the total study area was delineated as a relatively safe zone (F < 1.5 mg/L) and the remaining 38.50% (689.18 km2) was demarcated under the unsafe zone (F > 1.5 mg/L). The proposed FCZs model corroborates a significant agreement of 85% with the 61 observed locations and thus testify to the model reliability.