Mechanical Thrombectomy in Acute Basilar Artery Stroke: A Systematic Review and Meta-analysis of Randomized Controlled Trials

doi:10.21203/rs.3.rs-1758290/v1

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Mechanical Thrombectomy in Acute Basilar Artery Stroke: A Systematic Review and Meta-analysis of Randomized Controlled Trials

https://doi.org/10.21203/rs.3.rs-1758290/v1

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Background

The evidence for mechanical thrombectomy in acute basilar artery occlusion has until now remained inconclusive with basilar artery strokes associated with high rates of death and disability. This systematic review and meta-analysis will summarize the available evidence for the effectiveness of mechanical thrombectomy in acute basilar artery occlusion compared to best medical therapy.

Methods

A systematic review and meta-analysis was performed and presented in conformity with the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) to test the primary hypothesis that mechanical thrombectomy for basilar artery occlusion is associated with a different rate of good neurological outcome (modified Rankin Scale (mRS) ≤ 3) at day 90. Secondary outcomes included mortality, symptomatic intracranial hemorrhage (sICH) and excellent functional outcome (mRS ≤ 2). We calculated risk ratios (RRs) and 95% confidence intervals (CIs) to summarize the effect estimates for each outcome.

Results

We performed a random effects (Mantel-Haenszel) meta-analysis of the four included randomized controlled trials comprising a total of 988 participants. We found a statistically significant improvement in the rates of those with a good functional outcome (mRS 0–3, RR 1.54, 1.16–2.06, p = 0.003) and an excellent functional outcome (mRS 0–2, RR 1.69, 1.05–2.71, p = 0.03) in those who were treated with thrombectomy when compared to best medical therapy alone. Thrombectomy was associated with a higher level of sICH (RR 7.12, 2.16–23.54, p = 0.001) but this was not reflected in a higher mortality rate, conversely the mortality rate was significantly lower in the intervention group (RR 0.76, 0.65–0.89, p = 0.0004).

Conclusions

Our meta-analysis of the recently presented randomized controlled studies is the first to confirm the disability and mortality benefit of mechanical thrombectomy in basilar artery stroke.

Basilar

Stroke

Meta-analysis

Mechanical Thrombectomy

Randomized Controlled Trials

The basilar artery is the primary blood supply to the posterior circulation supplying the brain stem, occipital lobes, thalami and cerebellum. Acute basilar artery occlusion (BAO) is a rare but devastating cause of stroke with a mortality rate of up to 45%[1]. Previous randomized controlled trials (RCTs) have formed the basis for the use of mechanical thrombectomy (MT) in the anterior circulation and have revolutionized acute stroke treatment[2, 3], however only one of these trials, THRACE (Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke) included a small number of patients with BAO (4 patients in total)[4].

Two recent randomized trials, BEST (Basilar Artery Occlusion Endovascular Intervention Versus Standard Medical Treatment)[5] and BASICS (Basilar Artery International Cooperation Study)[6] failed to show a benefit in terms of functional disability and mortality at 90 days, however these trials were plagued with slow recruitment (2011–2019 in BASICs and 2015–2017 in BEST), large numbers of patients treated outside of the trial protocol (29% in BASICS and 55% in BEST) and suffered from high crossover rates (22% in BEST). The lack of a positive outcome was disappointing and unexpected given the high rates of recanalization and the poor prognosis associated with basilar artery occlusion.

The research landscape has now changed significantly following the presentation of the first two positive randomized trials, ATTENTION (Endovascular treatment for acute basilar artery occlusion)[7, 8] and BAOCHE (Basilar Artery Occlusion Chinese Endovascular trial)[9, 10] at the European Stroke Conference (2022)[11]. We present a meta-analysis of the combined results from all four RCTs including the presented data in order to better understand the role of MT in BAO.

Protocol and guidance

The meta-analysis conducted adheres to the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)[12]. We included randomized controlled trials (RCTs) with a parallel design that randomized participants to BMT and MT versus BMT alone.

Literature search and data extraction

We conducted a systematic review using Embase, Medline and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to July 2022. Appendix A contains the predefined search strategy.

We also searched the following trial registers, the US National Institutes of Health Ongoing Trials Register: ClinicalTrials.gov[13] , the World Health Organization International Clinical Trials Registry Platform[14] and reviewed the reference list of key papers. In an effort to identify further published, unpublished, and ongoing trials, we conducted a search of various gray literature sources, dissertation and theses databases, and databases of conference abstracts. No time limits or language restrictions were used.

Eligibility of the studies for the quantitative analysis was rated by four independent readers (AM, BD, BL, and IB). We collated multiple reports of the same study so that each study, not each reference, was the unit of interest in the review. Randomized, single blinded studies were included into the quantitative synopsis if the study followed patients up for at least 90 days using the modified Rankin Score (mRS)[15] and reported on adverse events and mortality.

Patients must have been included within 24 hours of stroke onset and have a clinical syndrome in keeping with a posterior circulation stroke. We defined BMT as thrombolysis, antiplatelet or antithrombotic treatment. Data inconsistencies in the papers selected for inclusion were discussed and resolved by mutual consensus.

Statistical analysis

For the dichotomous outcomes we combined the pooled individual study RRs and 95% confidence intervals (CIs) for each outcome using a random-effects Mantel-Haenszel model given the potential for methodological heterogeneity (see Discussion). In included studies we treated the participant as the unit of analysis. We used both a visual inspection of CIs and the I² statistic to calculate the degree of statistical heterogeneity; where we took an I² value of 50% as an indicator of moderate heterogeneity, and an I² of ≥75% as an indicator of substantial heterogeneity.

Results of the search

Our database searches retrieved a total of 687 articles, following the review process we identified four randomized trials (see Figure 1). Two from the initial search strategy and two following the presentation of two randomized trials (ATTENTION[7] and BAOCHE[9]) at the European Stroke Conference[11]. Although the full texts were not available for these articles, we found sufficient information from the presented data in order to conduct a meta-analysis.

Included studies

Four randomized, single blinded studies were included in the quantitative analysis[5, 6, 8, 10]. The trials included participants aged greater than 18 who had a clinical posterior circulation stroke syndrome with confirmed basilar occlusion on CT angiogram or MR angiogram imaging. The trials included participants thrombolysed if presenting with no contraindications. We defined sICH as per the individual trials’ primary analysis.

Characteristics of included trials

All four randomized controlled trials have similar study designs (randomized, prospective, open-label trials with blinded outcome assessment) with a primary outcome of a modified Rankin Score of 0-3 at 90 days (See Table 1: Key characteristics).

BASICS (Basilar Artery International Cooperation Study)

BASICS took place over eight years with 300 participants enrolled and a low crossover rate of 3.33%. The slow recruitment rate of BASICS does call into question the presence of bias in the enrolled population. Trial centers involved in BASICS had high rates of treatment of eligible patients outside the trial (29.2%) of which a high percentage of patients went on to receive endovascular therapy (79%). Furthermore, over the course of the study, there were amendments to the methodology to facilitate recruitment. This led to the inclusion of more mild strokes (NIHSS <10) which could lead to an undervaluing of the effect of endovascular therapy.

There was no significant difference between the primary outcome measure in the endovascular therapy arm (44.2%) vs best medical therapy (37.7%). Mortality rates were not significantly different (38.3% with intervention and 43.2% with best medical therapy). However, symptomatic ICH rates were higher as expected with endovascular therapy. Whilst not powered, the subgroup analysis of mild strokes does suggest that patients with mild strokes did better with best medical therapy (a high rate of use of intravenous thrombolysis in BASICS, near 80% in both arms) whereas those with larger strokes (NIHSS >10) did better with endovascular therapy.

BEST (Basilar Artery Occlusion Endovascular Intervention vs Standard Medical Treatment)

BEST was a multi-center Chinese trial (28 centers) which took place over 3 years and intended to recruit 288 participants. However, the trial was terminated early with only 131 patients enrolled due to a high crossover rate of 13% (much higher than the other 3 RCTs discussed in this paper, which all had <5% crossover rate). When looking at the baseline demographics of the patients recruited, the patients of BEST had a noticeably higher admission NIHSS (32 in intervention and 26 in control) vs other trials which tended to a median NIHSS of 19-22.

With the intention to treat analysis, there was no statistically significant difference between the trial arms. However, a second look accounting for the effect of crossovers (majority of crossovers in this trial were patients who were randomized to best medical therapy alone and went on to have endovascular therapy) showed that more patients achieved the primary outcome with endovascular therapy compared to best medical therapy alone in both per-protocol (44% vs 25%) and as treated populations (47% vs 24%). Unlike ATTENTION and BAOCHE, mortality figures were not different between trial arms despite a higher rate of symptomatic ICH in patients who received endovascular therapy.

ATTENTION (Endovascular Treatment of Acute Basilar Artery Occlusion)

In comparison to BEST and BASICS, ATTENTION randomized patients with an extended window of 0-12 hours. In contrast to the other studies discussed in this paper, ATTENTION had a randomization rate of 2:1 for intervention to control arms and the trial took place across 36 high volume Chinese thrombectomy centers. One third of patients in both arms received intravenous thrombolysis.

The most statistically significant finding was that 46% of the endovascular therapy group achieved the primary outcome of mRS 0-3 at 90 days compared to only 22.8% in the best medical therapy arm (with an adjusted risk ratio of 2.1, p <0.001). ATTENTION was also positive in its secondary outcomes with patients who received endovascular therapy fairing better in terms of overall disability (odds radio 2.8 (1.8 – 4.4 CI) and more independent functional outcomes (33.2% compared to 10.5% in best medical therapy (adjusted risk ratio 3.2, 1.8 – 5.4). Similar to BAOCHE, there were more symptomatic intracranial hemorrhagic events. Despite this, mortality was significantly reduced following endovascular therapy (36.7% vs 55.3% with best medical therapy).

BAOCHE (Basilar Artery Occlusion Chinese Endovascular Trial)

BAOCHE is the first randomized trial which investigated the outcomes in late presenters with BAO. Patients were only randomized within the 6 – 24 hour window from symptom onset where they were ineligible for intravenous thrombolysis or had not achieved recanalization after IVT.

Although the trial aimed to recruit 318 patients, the trial was terminated at the planned interim analysis after 217 patients were enrolled due to the statistically significant difference in primary outcome. 46.4% of patients who received endovascular therapy compared to 24.3% of patients who received best medical therapy along achieved the primary outcome with an adjusted odds ratio of 2.92 (1.56 – 5.47, p = 0.001). In terms of safety, whilst the intervention arm had a higher rate of symptomatic intracranial hemorrhages (as per ECASS-II criteria), the overall 90 day mortality was less in the intervention arm (30.9% compared to 42.1% in the control arm).

Table 1: Key characteristics

	BASICS	BEST	ATTENTION	BAOCHE
Date	2011-2019	2015-2017	2021-2022	2016-2022
Symptom onset to inclusion (hours)	0-6	0-8	0-12	6-24
Number screened	424	288	507	Data not available
Number of participants	300	131	340	217
Crossover (percentage)	3/154 (1.9) to BMT 7/146 (4.7) to MT	3/66 (4.5) to BMT 14/65 (21.5) to MT	3/226 (1.3) to BMT 3/114 (2.6) to MT	1/110 (0.9) to BMT 4/107 (3.7) to MT
Median NIHSS at presentation (IQR)	Intervention: 21.9 Control: 22.1 (IQR not available)	Intervention: 32 (18-38) Control: 26 (13-37)	Intervention: 24 (15-35) Control: 24 (14-35)	Intervention: 20 (14.5-29) Control: 19 (12-30)
Intravenous thrombolysis (%)	Intervention: 121/154 (78.6) Control: 116/146 (79.5)	Intervention: 18/66 (27) Control: 21/65 (32)	Intervention: 69/226 (30.5) Control: 39/114 (34.2)	Intervention: 15/110(13.6) Control: 23/107 (21.5)
Blinding	Open-label, blinded outcome assessment	Open-label, blinded outcome assessment	Open-label, blinded outcome assessment	Open-label, blinded outcome assessment
mRS (≤3) (percentage)	Intervention: 68/154 (44.1) Control: 55/146 (37.6)	Intervention: 28/66 (42.4) Control: 21/65 (32.3)	Intervention: 104/226 (46) Control: 26/114 (22.8)	Intervention: 51/110 (46.3) Control: 26/107 (24.2)
Mortality at day 90 (percentage)	Intervention: 59 (38.3) Control: 63 (43.2)	Intervention: 22 (33.3) Control: 25 (38.4)	Intervention: 83 (36.7) Control: 63 (55.2)	Intervention: 34 (30.9) Control: 45 (42.1)
sICH (percentage)	Intervention: 6 (4.5) Control: 1 (0.7)	Intervention: 5 (8) Control: 0	Intervention: 12 (5) Control: 0	Intervention: 6 (8.8) Control: 1 (2.3)
Follow up:	24hrs, 90 days	24hrs, 90 days	24hrs, 90 days	24hrs, 90 days, 6 months, 1 year

We performed a random effects meta-analysis of the four randomized trials (See Fig. 2: Forest plot of primary and secondary outcomes) comprising a total number of 988 participants [5, 6, 8, 10]. 556 were included in the thrombectomy arm verses vs 432 to best medical therapy. We found a statistically significant benefit in the number of patients with a good functional outcome (mRS 0–3) (RR 1.54, 1.16–2.06, p = 0.003) and an excellent functional outcome (mRS 0–2) (RR 1.69, 1.05–2.71, p = 0.03) who were treated with thrombectomy when compared to best medical therapy. Thrombectomy was associated with a higher level of sICH (RR 7.12, 2.16–23.54, p = 0.001) but this was not reflected in the mortality rate, in contrast MT was associated with a lower mortality rate (RR 0.76, 0.65–0.89, p = 0.0004) confirming the benefit of thrombectomy in BAO.

There is now overwhelming data to support the use of thrombectomy in patients with an acute basilar occlusion with improved disability rates and mortality despite higher rates of sICH. We deemed the trials of good quality with randomization and blinding to outcome assessment appropriately performed.

We found no statistical heterogeneity in the sICH and mortality data. We found moderate statistical heterogeneity in the disability outcome measures but not on visual inspection, we therefore deemed the trials similar enough to combine in a random effects meta-analysis.

Due to the number of trials being too small and lacking a varied sample size for a meaningful analysis, the included studies did not fit the criteria for funnel plot analysis proposed by the Cochrane Collaboration Handbook[16]. We ensured that publication bias was minimized by reviewing conference abstracts and clinical trial registers in order to identify trials conducted but unpublished.

There were large numbers of screened patients treated outside of the trial protocol in BASICS (29%) and BEST(55%) eluding to a degree of bias in the study population and high crossover rates in the BEST trial (22% in the medical group) which may have diluted the size of the treatment effect in these trials[5, 6], however, the ATTENTION and BAOCHE trials had rapid recruitment with minimal crossover rates[8, 10].

Certain questions remain unanswered such as the role of thrombolysis and optimal time windows in order to achieve reperfusion. Two of the included trials enrolled late presenting patients (8–24 hours)[5, 10] and there was variability in the number of patients thrombolysed with BASICs thrombolysing up to 78% of enrolled patients compared to 15–23% in the BAOCHE[6, 10].

Three of the studies were conducted in China which is known to have a higher degree of patients with intracranial atherosclerotic disease[17] (BEST (52%) and BASICS (33%)) which we can speculate may affect the generalizability of the results in a Western population[5, 6, 10]. We suggest an individual patient data analysis once the full trial results are available, to better understand the role of timings, prognostic characteristics and thrombolysis in BAO.

The long awaited question of whether to use MT in BAO has now been answered.

MT is associated with lower rates of disability and death in BAO despite an increase risk of sICH. We await the full publication of the ATTENTION and BAOCHE, however given the critical nature of basilar artery occlusion we put forward the results for dissemination.

Abbreviations and Acronyms
BAO	Basilar Artery Occlusion
BMT	Best medical therapy
MT	Mechanical thrombectomy
mRS	modified Rankin Scale
NIHSS	National Institute of Health Stroke Scale
CTA	Computed tomography angiography
MRA	Magnetic resonance angiography
TICI	Thrombolysis in Cerebral Infarction
PRISMA	Preferred Reporting Items for Systematic Reviews and Meta-Analyses
RR	Relative Risk or Risk Ratio
CI	Confidence Interval
ICH	Intracranial Haemorrhage
sICH	Symptomatic Intracranial Haemorrhage

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Availability of data and materials

The datasets used and/or analyzed during the current study are available from

the corresponding author on reasonable request.

Competing interests

The authors declare that they have no competing interests

Funding

Not applicable

Authors' contributions

AM designed the study, pooled data and wrote the initial findings. BD and SB helped with writing and edited the paper. IB, BL, KS, OR and OV performed the search and extraction of data. LD, ZB, JK, OH, SJ, DK , MV, HJ, NR, AS, MP, CH, GF, DR and KL were involved with editing and advice.

Acknowledgments

Not applicable

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No competing interests reported.

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Mechanical Thrombectomy in Acute Basilar Artery Stroke: A Systematic Review and Meta-analysis of Randomized Controlled Trials

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