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Research article
Sheng Ye
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1281-1735
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This work is licensed under a CC BY 4.0 License. Read Full License
BACKGROUND Chronic subdural hematoma (CSDH) is fundamentally treatable with about 2-31% recurrence rate. Recently, there has been renewed interest in the association between Blood Urea Nitrogen (BUN) and intracranial lesion. Therefore, this paper attempts to show the relationship between BUN and CSDH recurrence.
METHODS A total of 661 CSDH cases with Burr-hole Irrigation (BHI) were enrolled from December 2014 to April 2019. The analyzed parameters included age, gender, comorbidities, laboratory investigations, medication use and hematoma location. The cases were divided into recurrence and non-recurrence groups while postoperative BUN concentration was further separated into quartiles (Q1 ≤ 4.0 mmol/L, 4.0 < Q2 ≤ 4.9 mmol/L, 4.9 < Q2 ≤ 6.4 mmol/L, Q4 > 6.4 mmol/L). Restricted cubic spline regressions and logistic regression models were performed to estimate the effect of BUN on CSDH recurrence.
RESULTS CSDH recurrence was observed in 97(14.8%) cases. Significant distinctions were observed between recurrence and non-recurrence groups in BUN quartiles of cases ( P =0.004). After adjusting for the potential confounders, the odds ratio of recurrence was 3.124 (95%CI =1.509–6.468, p = 0.002) for the highest quartile of BUN compared with the lowest quartile. In multiple-adjusted spline regression, high BUN level visually showed significantly high OR value of recurrence risk.
CONCLUSIONS Elevated BUN at post-operation is significantly associated with the recurrence of CSDH, and it is indicated that high levels of serum BUN after evacuation may be served as a risk factor for CSDH recurrence.
Keywords
Chronic subdural hematoma, Blood urea nitrogen (BUN), Recurrence rate
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Neurology.
No community comments so far
Editorial decision: Accept
On 28 Oct, 2020
Editor assigned
On 27 Oct, 2020
Submission checks complete
On 26 Oct, 2020
Editor invited
On 26 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 23 Oct, 2020
Reviewer #1 agreed
On 25 Aug, 2020
Reviewers invited
Invitations sent on 20 Aug, 2020
Editor assigned
On 18 Aug, 2020
Submission checks complete
On 17 Aug, 2020
Editor invited
On 17 Aug, 2020
Version 1
Posted 18 Mar, 2020
No comments provided
Editorial decision: Major revision
On 05 Aug, 2020
Review #2 received
Received 29 Jul, 2020
Reviewer #2 agreed
On 25 Jul, 2020
Review #1 received
Received 29 Jun, 2020
Reviewer #1 agreed
On 24 May, 2020
Reviewers invited
Invitations sent on 24 Mar, 2020
Editor assigned
On 11 Mar, 2020
First submitted
On 10 Mar, 2020
Submission checks complete
On 10 Mar, 2020
Editor invited
On 10 Mar, 2020
Metrics
Comments: 0
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A new preprint design is coming!
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See the published version of this preprint at BMC Neurology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Sheng Ye
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1281-1735
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Neurology.
No community comments so far
Editorial decision: Accept
On 28 Oct, 2020
Editor assigned
On 27 Oct, 2020
Submission checks complete
On 26 Oct, 2020
Editor invited
On 26 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 23 Oct, 2020
Reviewer #1 agreed
On 25 Aug, 2020
Reviewers invited
Invitations sent on 20 Aug, 2020
Editor assigned
On 18 Aug, 2020
Submission checks complete
On 17 Aug, 2020
Editor invited
On 17 Aug, 2020
Version 1
Posted 18 Mar, 2020
No comments provided
Editorial decision: Major revision
On 05 Aug, 2020
Review #2 received
Received 29 Jul, 2020
Reviewer #2 agreed
On 25 Jul, 2020
Review #1 received
Received 29 Jun, 2020
Reviewer #1 agreed
On 24 May, 2020
Reviewers invited
Invitations sent on 24 Mar, 2020
Editor assigned
On 11 Mar, 2020
First submitted
On 10 Mar, 2020
Submission checks complete
On 10 Mar, 2020
Editor invited
On 10 Mar, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Neurology.
BACKGROUND Chronic subdural hematoma (CSDH) is fundamentally treatable with about 2-31% recurrence rate. Recently, there has been renewed interest in the association between Blood Urea Nitrogen (BUN) and intracranial lesion. Therefore, this paper attempts to show the relationship between BUN and CSDH recurrence.
METHODS A total of 661 CSDH cases with Burr-hole Irrigation (BHI) were enrolled from December 2014 to April 2019. The analyzed parameters included age, gender, comorbidities, laboratory investigations, medication use and hematoma location. The cases were divided into recurrence and non-recurrence groups while postoperative BUN concentration was further separated into quartiles (Q1 ≤ 4.0 mmol/L, 4.0 < Q2 ≤ 4.9 mmol/L, 4.9 < Q2 ≤ 6.4 mmol/L, Q4 > 6.4 mmol/L). Restricted cubic spline regressions and logistic regression models were performed to estimate the effect of BUN on CSDH recurrence.
RESULTS CSDH recurrence was observed in 97(14.8%) cases. Significant distinctions were observed between recurrence and non-recurrence groups in BUN quartiles of cases ( P =0.004). After adjusting for the potential confounders, the odds ratio of recurrence was 3.124 (95%CI =1.509–6.468, p = 0.002) for the highest quartile of BUN compared with the lowest quartile. In multiple-adjusted spline regression, high BUN level visually showed significantly high OR value of recurrence risk.
CONCLUSIONS Elevated BUN at post-operation is significantly associated with the recurrence of CSDH, and it is indicated that high levels of serum BUN after evacuation may be served as a risk factor for CSDH recurrence.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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