In this paper, HI- antenna is applied for monitoring the fluctuating diabetes. HI antenna senses the human pancreas dielectric radiation. HI antenna senses the radiation effectively because of shape and size of slot, which covers the pancreas region of human body, without change in crumbling effect during dielectric radiation signal acquisition. The dielectric radiations signal acquisition from pancreas lead to effective monitoring of fluctuating diabetes. However, traditional non-invasive method never monitors fluctuating diabetes, whereas they only measure diabetic value through non-invasive method. Non-invasive method of diabetic measurement never measures fluctuating diabetes due to improper mounting of sensor over the body is the major problem. The proposed HI-shaped antenna is mounted in different part of the human body such as hand, finger, stomach and pancreas for measuring fluctuating diabetes. Among the different part of body, optimized location is the pancreas of measuring diabetes is detected with proposed HI-shaped antenna. Moreover, different type of such as Microstrip antenna, log periodic antenna and are compared with the proposed HI-shaped antenna for diabetes measurement and proposed antenna dielectric signal statical values correlated with diabetic laboratory values. The proposed antenna measures the fluctuation diabetes with 85% accuracy.