Active manipulation of Fano resonance at visible and near-IR wavelengths in metal nanodevices is one of the important challenges for applications such as chemical and biological sensing. Here, we theoretically research an active manipulation of Fano resonance at visible and near-IR wavelengths in gold plasmonic nanodevices with graphene. The surface plasmon resonance of the gold plasmonic nanodevice with graphene has three resonance peaks, and this can be explained by the distribution of the electric field in the nanodevice. The Fano resonance wavelength of the gold plasmonic nanodevice with graphene has a significant blue-shift compared with the gold nanodevices without graphene. Moreover, the Fano resonance dependens on the length and position of Au nanorods and the environment refractive index. The figure of merit of the gold nanodevice with graphene can be as high as 41.3, which makes the system suitable for high sensitivity applications. Finally, we actively manipulate the absorption spectrum and the reflected light phase through changing the Fermi energy of graphene. These results suggest an original method for the design of an actively manipulated Fano resonance nanodevice.