This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Yanjuan Lin
Fujian Medical University Union Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0368-4893
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Blood glucose variability is associated with poor prognosis after cardiac surgery, but the relationship between glucose variability and postoperative delirium in patients with acute aortic dissection is unclear. The aim of this study is to investigate the association of blood glucose variability with postoperative delirium in acute aortic dissection patients.
Methods
We prospectively analyzed 257 patients including 103 patients with delirium. The patients was categorized into two groups according to whether delirium was present. The outcome measures were postoperative delirium, the length of Intensive Care Unit stay and the duration of hospital stay. Multivariable Cox competing risk survival models was used to assess.
Results
A total of 257 subjects were enrolled, including 103 patients with delirium. There were statistically significant differences between the two groups in age, body mass index, first admission blood glucose, white blood cell counts, Acute Physiology and Chronic Health Evaluation II score, hypoxemia, mechanical ventilation duration and the length of Intensive Care Unit stay (P < 0.05). The median of mean of blood glucose and standard deviation of blood glucose were higher in the delirium group than in the non-delirium group, and the difference was statistically significant (P < 0.05). In model 1, the adjusted hazard ratio of standard deviation of blood glucose was 1.436 (P < 0.05). In Model 2, the SDBG (AHR = 1.418, 95% CI = 1.195–1.681, P < 0.05) remained significant after adjusting for confounders (P < 0.05). The area under curve of the SDBG ROC was 0.763 (95% CI = 0.704–0.821, P < 0.01). The sensitivity was 81.6%, and the specificity was 57.8%.
Conclusions
Glucose variability is associated with the risk of delirium in patients after aortic dissection surgery, and high glycemic variability increases the risk of postoperative delirium.
Keywords
glucose variability, postoperative delirium, acute aortic dissection patients
Figure 1
Figure 2
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 21 Apr, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
This is a preprint. It has not completed peer review.
Research article
Yanjuan Lin
Fujian Medical University Union Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0368-4893
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 21 Apr, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Blood glucose variability is associated with poor prognosis after cardiac surgery, but the relationship between glucose variability and postoperative delirium in patients with acute aortic dissection is unclear. The aim of this study is to investigate the association of blood glucose variability with postoperative delirium in acute aortic dissection patients.
Methods
We prospectively analyzed 257 patients including 103 patients with delirium. The patients was categorized into two groups according to whether delirium was present. The outcome measures were postoperative delirium, the length of Intensive Care Unit stay and the duration of hospital stay. Multivariable Cox competing risk survival models was used to assess.
Results
A total of 257 subjects were enrolled, including 103 patients with delirium. There were statistically significant differences between the two groups in age, body mass index, first admission blood glucose, white blood cell counts, Acute Physiology and Chronic Health Evaluation II score, hypoxemia, mechanical ventilation duration and the length of Intensive Care Unit stay (P < 0.05). The median of mean of blood glucose and standard deviation of blood glucose were higher in the delirium group than in the non-delirium group, and the difference was statistically significant (P < 0.05). In model 1, the adjusted hazard ratio of standard deviation of blood glucose was 1.436 (P < 0.05). In Model 2, the SDBG (AHR = 1.418, 95% CI = 1.195–1.681, P < 0.05) remained significant after adjusting for confounders (P < 0.05). The area under curve of the SDBG ROC was 0.763 (95% CI = 0.704–0.821, P < 0.01). The sensitivity was 81.6%, and the specificity was 57.8%.
Conclusions
Glucose variability is associated with the risk of delirium in patients after aortic dissection surgery, and high glycemic variability increases the risk of postoperative delirium.
Figure 1
Figure 2
Loading...