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Research
Jingming Dong
Tianjin hosipital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2857-3914
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Proximal humerus fractures are highly related to age, and are particularly high in women. The goal of this study was to investigate sex-related similarities and differences in humeral head structure.
Methods
Computed tomography (CT) scans of 147 healthy subjects (76 men /71 women) spanning a wide range of ages (20-88 years) were analyzed. Three groups of subjects were identified according to age: group A (aged 20-39 years), group B (aged 40-59 years), and group C (aged> 60 years). For each subject, cortical bone mapping (CBM) was applied to create color 3D thickness map for the proximal humerus. Regions of interest (ROI) were defined in three walls of humeral head which corresponded to the anterior, lateral and posterior aspects. Cortical parameters, including the cortical thickness (CTh), cortical mass surface density (CM), and the endocortical trabecular density (ECTD) were measured using CBM.
Results
In both sexes, the CTh value of proximal ROIs in lateral and anterior wall tended to decrease with age. No significant difference was detected between three age groups for each parameter in the posterior wall in men and women. In ROIs 1-9, the ECTD tended to show a notable decline with age in women. In contrast, the ECTD remained unchanged in men. When pooled across all decades, the CTh, CM and ECTD values of ROI 1-9 were approximately equivalent between men and women.
Conclusions
There was no sex difference in cortical bone parameters in the humeral head region. However, the endocortical trabecular density decreased significantly with age only in women.
Keywords
Cortical bone, humeral head, Sex, Age
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This is a preprint. It has not completed peer review.
Research
Jingming Dong
Tianjin hosipital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2857-3914
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 23 Mar, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Proximal humerus fractures are highly related to age, and are particularly high in women. The goal of this study was to investigate sex-related similarities and differences in humeral head structure.
Methods
Computed tomography (CT) scans of 147 healthy subjects (76 men /71 women) spanning a wide range of ages (20-88 years) were analyzed. Three groups of subjects were identified according to age: group A (aged 20-39 years), group B (aged 40-59 years), and group C (aged> 60 years). For each subject, cortical bone mapping (CBM) was applied to create color 3D thickness map for the proximal humerus. Regions of interest (ROI) were defined in three walls of humeral head which corresponded to the anterior, lateral and posterior aspects. Cortical parameters, including the cortical thickness (CTh), cortical mass surface density (CM), and the endocortical trabecular density (ECTD) were measured using CBM.
Results
In both sexes, the CTh value of proximal ROIs in lateral and anterior wall tended to decrease with age. No significant difference was detected between three age groups for each parameter in the posterior wall in men and women. In ROIs 1-9, the ECTD tended to show a notable decline with age in women. In contrast, the ECTD remained unchanged in men. When pooled across all decades, the CTh, CM and ECTD values of ROI 1-9 were approximately equivalent between men and women.
Conclusions
There was no sex difference in cortical bone parameters in the humeral head region. However, the endocortical trabecular density decreased significantly with age only in women.
Figure 1
Figure 2
Figure 3
Figure 4
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