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Research article
Ping-Ting Lin
Chung Shan Medical University
Corresponding Author
License:
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Background
Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with head and neck cancer according to tumor-node-metastasis (TNM) stages.
Methods
A total of 194 patients with head and neck cancer were enrolled in this study. The levels of antioxidant vitamins (ubiquinone, β-carotene, vitamin A and E), metabolic parameters, oxidative stress, antioxidant enzymes activity, and inflammatory markers were measured.
Results
More than half of the subjects had high blood pressure, central obesity, hyperglycemia, and hyperlipidemia regardless of TNM stage. With regard to antioxidant vitamins status, 46% and 94% of patients had β-carotene and ubiquinone deficiency, respectively. Patients in T3 and T4 stages had significantly lower antioxidant enzyme (catalase, p = 0.03) activity and higher inflammatory markers levels (high sensitivity C-reactive protein and interleukin-6, p < 0.01) than patients in the other stages. In addition, the level of β-carotene was negatively associated with waist circumference, and ubiquinone was positively associated with the level of high-density lipoprotein cholesterol (p < 0.05). Higher β-carotene and ubiquinone levels were negatively associated with hypertriglyceridemia and the risk of metabolic syndrome (p < 0.05).
Conclusions
A high proportion of patients with head and neck cancer had ubiquinone or β-carotene deficiency and metabolic disorders. The level of ubiquinone or β-carotene was negatively associated with the risk of central obesity, hypertriglyceridemia, and metabolic syndrome. Since patients with head and neck cancer suffer from high oxidative stress and inflammation (particularly in the T3 and T4 stages), supplementation with antioxidant vitamins such as ubiquinone or β-carotene could be preferentially applied.
Keywords
ubiquinone; B-carotene; antioxidant vitamins; metabolic disorders; head and neck cancer
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Cancer.
No community comments so far
Editorial decision: Accept
On 07 Apr, 2020
Review #1 received
Received 02 Apr, 2020
Reviewer #2 agreed
On 01 Apr, 2020
Review #2 received
Received 01 Apr, 2020
Editor assigned
On 27 Mar, 2020
Reviewers invited
Invitations sent on 27 Mar, 2020
Reviewer #1 agreed
On 27 Mar, 2020
Submission checks complete
On 26 Mar, 2020
Editor invited
On 26 Mar, 2020
Version 1
Posted 02 Jul, 2019
No comments provided
Editorial decision: Major revision
On 21 Mar, 2020
Review #2 received
Received 17 Mar, 2020
Reviewer #2 agreed
On 11 Mar, 2020
Review #1 received
Received 28 Oct, 2019
Reviewer #1 agreed
On 13 Oct, 2019
Reviewers invited
Invitations sent on 24 Jul, 2019
Submission checks complete
On 28 Jun, 2019
Editor assigned
On 28 Jun, 2019
Editor invited
On 27 Jun, 2019
First submitted
On 22 May, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Cancer.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Ping-Ting Lin
Chung Shan Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Cancer.
No community comments so far
Editorial decision: Accept
On 07 Apr, 2020
Review #1 received
Received 02 Apr, 2020
Reviewer #2 agreed
On 01 Apr, 2020
Review #2 received
Received 01 Apr, 2020
Editor assigned
On 27 Mar, 2020
Reviewers invited
Invitations sent on 27 Mar, 2020
Reviewer #1 agreed
On 27 Mar, 2020
Submission checks complete
On 26 Mar, 2020
Editor invited
On 26 Mar, 2020
Version 1
Posted 02 Jul, 2019
No comments provided
Editorial decision: Major revision
On 21 Mar, 2020
Review #2 received
Received 17 Mar, 2020
Reviewer #2 agreed
On 11 Mar, 2020
Review #1 received
Received 28 Oct, 2019
Reviewer #1 agreed
On 13 Oct, 2019
Reviewers invited
Invitations sent on 24 Jul, 2019
Submission checks complete
On 28 Jun, 2019
Editor assigned
On 28 Jun, 2019
Editor invited
On 27 Jun, 2019
First submitted
On 22 May, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Cancer.
Background
Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with head and neck cancer according to tumor-node-metastasis (TNM) stages.
Methods
A total of 194 patients with head and neck cancer were enrolled in this study. The levels of antioxidant vitamins (ubiquinone, β-carotene, vitamin A and E), metabolic parameters, oxidative stress, antioxidant enzymes activity, and inflammatory markers were measured.
Results
More than half of the subjects had high blood pressure, central obesity, hyperglycemia, and hyperlipidemia regardless of TNM stage. With regard to antioxidant vitamins status, 46% and 94% of patients had β-carotene and ubiquinone deficiency, respectively. Patients in T3 and T4 stages had significantly lower antioxidant enzyme (catalase, p = 0.03) activity and higher inflammatory markers levels (high sensitivity C-reactive protein and interleukin-6, p < 0.01) than patients in the other stages. In addition, the level of β-carotene was negatively associated with waist circumference, and ubiquinone was positively associated with the level of high-density lipoprotein cholesterol (p < 0.05). Higher β-carotene and ubiquinone levels were negatively associated with hypertriglyceridemia and the risk of metabolic syndrome (p < 0.05).
Conclusions
A high proportion of patients with head and neck cancer had ubiquinone or β-carotene deficiency and metabolic disorders. The level of ubiquinone or β-carotene was negatively associated with the risk of central obesity, hypertriglyceridemia, and metabolic syndrome. Since patients with head and neck cancer suffer from high oxidative stress and inflammation (particularly in the T3 and T4 stages), supplementation with antioxidant vitamins such as ubiquinone or β-carotene could be preferentially applied.
Figure 1
Figure 2
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