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Erwei Gu
First Affiliated Hospital of Anhui Medical University,anesthesiology
Corresponding Author
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Background: Although dexmedetomidine (Dex) is known to reduce bispectral index (BIS) values and propofol dosage, there is little information regarding raw electroencephalography (EEG) changes related to Dex deepening of propofol general anesthesia (GA). This study investigated Dex effects on propofol GA via analysis of EEG changes.
Methods: A study cohort of 21 surgical patients (age range, 20–60 years) categorized asASA (American Society ofAnesthesiologists) class I or II were enrolled. We used time-varying spectral and bicoherence methods to compare electroencephalogram signatures 5 min before versus 10 min after intravenous Dex injection under propofol GA. Means and medians are reported with 95% confidence intervals (CIs) and inter-quartile ranges (IQRs), respectively.
Results: Dex augmented the slow waves power and theta (θ) oscillation bicoherence peak from a mean (95% CI) of 22.1% (19.0, 25.2) to 25.2% (21.8, 28.6). Meanwhile, Dex reduced alpha (α) peak power and bicoherence from 3.5 dB (1.0, 6.0) and 41.5% (34.0, 49.0) to 1.7 dB (-0.6, 4.0) and 35.4% (29.0, 41.8), respectively, while diminishing the median frequency of α oscillation peak values and the mean frequency of α peaks in bicoherence spectra from 12.0 Hz (IQR: 11.2, 12.6) and 11.7 Hz (11.3, 12.2) to 11.1 Hz (IQR: 10.3, 11.8) Hz and 11.2 Hz (10.9, 11.6),respectively.
Conclusions: Profound EEG changes support the supposition that Dex enhances
propofol-induced GA from a moderate to a deeper state. The present findings provide a theoretical basis and reference regarding protocols aimed at reducing anesthetic/sedative dosage while maintaining sufficient depth of GA.
Clinical trial registration: ChiCTR, ChiCTR1900026955, Registered 27 October 2019, http://www.chictr.org.cn/showproj.aspx?proj=44495
Keywords
anesthesia monitoring, anesthesia depth, electroencephalogram, dexmedetomidine,propofol
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This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryDigitalMaterial1Fig.S1STROBEdiagram.docx
Supplementary Digital Material 1: Fig.S1 STROBE diagram
- SupplementaryDigitalMaterial2STROBEStatement.docx
Supplementary Digital Material 2: STROBE Statement
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 05 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 01 Jun, 2021
Review #1 received
Received 15 Mar, 2021
Reviewer #1 agreed
On 28 Feb, 2021
Reviewers invited
Invitations sent on 25 Feb, 2021
Editor assigned
On 08 Feb, 2021
Editor invited
On 08 Feb, 2021
Submission checks complete
On 29 Jan, 2021
First submitted
On 26 Jan, 2021
Metrics
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PDF Downloads: ...
HTML Views: ...
Subject Areas
Surgery
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This preprint is under consideration at Perioperative Medicine. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Erwei Gu
First Affiliated Hospital of Anhui Medical University,anesthesiology
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 05 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 01 Jun, 2021
Review #1 received
Received 15 Mar, 2021
Reviewer #1 agreed
On 28 Feb, 2021
Reviewers invited
Invitations sent on 25 Feb, 2021
Editor assigned
On 08 Feb, 2021
Editor invited
On 08 Feb, 2021
Submission checks complete
On 29 Jan, 2021
First submitted
On 26 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Surgery
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Although dexmedetomidine (Dex) is known to reduce bispectral index (BIS) values and propofol dosage, there is little information regarding raw electroencephalography (EEG) changes related to Dex deepening of propofol general anesthesia (GA). This study investigated Dex effects on propofol GA via analysis of EEG changes.
Methods: A study cohort of 21 surgical patients (age range, 20–60 years) categorized asASA (American Society ofAnesthesiologists) class I or II were enrolled. We used time-varying spectral and bicoherence methods to compare electroencephalogram signatures 5 min before versus 10 min after intravenous Dex injection under propofol GA. Means and medians are reported with 95% confidence intervals (CIs) and inter-quartile ranges (IQRs), respectively.
Results: Dex augmented the slow waves power and theta (θ) oscillation bicoherence peak from a mean (95% CI) of 22.1% (19.0, 25.2) to 25.2% (21.8, 28.6). Meanwhile, Dex reduced alpha (α) peak power and bicoherence from 3.5 dB (1.0, 6.0) and 41.5% (34.0, 49.0) to 1.7 dB (-0.6, 4.0) and 35.4% (29.0, 41.8), respectively, while diminishing the median frequency of α oscillation peak values and the mean frequency of α peaks in bicoherence spectra from 12.0 Hz (IQR: 11.2, 12.6) and 11.7 Hz (11.3, 12.2) to 11.1 Hz (IQR: 10.3, 11.8) Hz and 11.2 Hz (10.9, 11.6),respectively.
Conclusions: Profound EEG changes support the supposition that Dex enhances
propofol-induced GA from a moderate to a deeper state. The present findings provide a theoretical basis and reference regarding protocols aimed at reducing anesthetic/sedative dosage while maintaining sufficient depth of GA.
Clinical trial registration: ChiCTR, ChiCTR1900026955, Registered 27 October 2019, http://www.chictr.org.cn/showproj.aspx?proj=44495
Figure 1
Figure 2
Figure 3
Figure 4
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryDigitalMaterial1Fig.S1STROBEdiagram.docx
Supplementary Digital Material 1: Fig.S1 STROBE diagram
- SupplementaryDigitalMaterial2STROBEStatement.docx
Supplementary Digital Material 2: STROBE Statement
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