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Research
Wei Li
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8413-4924
Lin Sun
Shanghai Mental Health Center
Corresponding Author
Shifu Xiao
Shanghai Mental Health Center
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Plasma neurofilament light (NfL) levels have been considered as an especially promising biomarker for dementia, however, the mechanism of NfL regulating cognition is not very clear.
Methods
43 amnesic mild cognitive impairment(aMCI), 35 Alzheimer’s disease (AD) and 30 cognitively normal subjects were recruited. Plasma NfL levels were examined by the Single Molecule array (Simoa) technique; the volumes of the hippocampus and amygdala were calculated and compared by T1-weighted MRI; and cognitive function was assessed by the Beijing version of the Montreal Cognitive Assessment (MoCA)
Results
Our results showed significantly increased plasma NfL levels in AD group (29.42 pg/ml) compared to aMCI(15.92 pg/ml) group and normal (12.85 pg/ml) group (both p < 0.001), while there was no statistical difference (p>0.05) between aMCI group and normal group. And the results of partial correlation analysis showed that plasma NfL levels were negatively correlated (p<0.05)with MoCA total score (r=-0.415, p=0.013), right hippocampal volume(r=-0.335,p=0.036) and right amygdala volume(r=-0.337, p=0.048).
Conclusions
NfL in plasma of AD patients is significantly increased, and the protein is related to atrophy of right hippocampus and right amygdala.
Keywords
NfL, AD, aMCI, hippocampal, amygdala
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Wei Li
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8413-4924
Lin Sun
Shanghai Mental Health Center
Corresponding Author
Shifu Xiao
Shanghai Mental Health Center
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 23 Mar, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cognitive Neuroscience
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Plasma neurofilament light (NfL) levels have been considered as an especially promising biomarker for dementia, however, the mechanism of NfL regulating cognition is not very clear.
Methods
43 amnesic mild cognitive impairment(aMCI), 35 Alzheimer’s disease (AD) and 30 cognitively normal subjects were recruited. Plasma NfL levels were examined by the Single Molecule array (Simoa) technique; the volumes of the hippocampus and amygdala were calculated and compared by T1-weighted MRI; and cognitive function was assessed by the Beijing version of the Montreal Cognitive Assessment (MoCA)
Results
Our results showed significantly increased plasma NfL levels in AD group (29.42 pg/ml) compared to aMCI(15.92 pg/ml) group and normal (12.85 pg/ml) group (both p < 0.001), while there was no statistical difference (p>0.05) between aMCI group and normal group. And the results of partial correlation analysis showed that plasma NfL levels were negatively correlated (p<0.05)with MoCA total score (r=-0.415, p=0.013), right hippocampal volume(r=-0.335,p=0.036) and right amygdala volume(r=-0.337, p=0.048).
Conclusions
NfL in plasma of AD patients is significantly increased, and the protein is related to atrophy of right hippocampus and right amygdala.
Figure 1
Figure 2
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