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Research article
Yufeng Wang
Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1417-1460
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Oral lichen planus (OLP) is a relatively common mucocutaneous disorder, its causative factors and pathogenesis are not fully understood. The existing studies on the association between hematinic deficiencies and OLP are limited and inconsistent. The aim of this study was to assess the hematinic deficiencies in a cohort of OLP patients and evaluate the correlation between hematinic deficiencies and OLP.
Methods: 236 OLP patients and 226 age-and gender-matched healthy controls were enrolled in this study. The levels of hemoglobin (Hb), serum folate, vitamin B12 and ferritin were measured and compared between OLP patients and healthy controls. REU (reticular/hyperkeratotic, erosive/erythematous, ulcerative) scoring system was adopted and compared between the OLP patients with and without hematinic deficiencies. The correlation between hematinic deficiencies and OLP was analyzed.
Results: The frequencies of serum ferritin and vitamin B12 deficiency in OLP patients were both significantly higher than those of the healthy controls. According to gender and age, the profiles of hematinic deficiencies in OLP patients were significantly different. As for REU score, no significant difference existed between OLP patients with and without hematinic deficiencies. Both serum ferritin deficiency and serum vitamin B12 deficiency were significantly correlated with OLP. Conclusions The present study suggested a significant association between hematinic deficiencies and OLP. Iron, folate, and vitamin B12 levels in OLP patients should be monitored routinely. Further studies are warranted to explore the interactions between OLP and hematinic deficiencies.
Keywords
Oral lichen planus, Hematinic deficiencies, iron, folate, vitamin B12, correlation
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CURRENT STATUS: Published
View the published article at BMC Oral Health.
No community comments so far
Editorial decision: Accept
On 22 Aug, 2020
Editor assigned
On 03 Aug, 2020
Submission checks complete
On 02 Aug, 2020
Editor invited
On 02 Aug, 2020
Version 2
Posted 15 Jun, 2020
No comments provided
Editorial decision: Major revision
On 14 Jul, 2020
Review #2 received
Received 06 Jul, 2020
Reviewer #3 agreed
On 20 Jun, 2020
Review #1 received
Received 20 Jun, 2020
Reviewer #2 agreed
On 19 Jun, 2020
Reviewers invited
Invitations sent on 16 Jun, 2020
Reviewer #1 agreed
On 16 Jun, 2020
Editor assigned
On 10 Jun, 2020
Submission checks complete
On 09 Jun, 2020
Editor invited
On 09 Jun, 2020
No comments provided
Editorial decision: Major revision
On 13 May, 2020
Review #4 received
Received 18 Apr, 2020
Review #3 received
Received 08 Apr, 2020
Reviewer #4 agreed
On 31 Mar, 2020
Reviewer #2 agreed
On 28 Mar, 2020
Reviewer #3 agreed
On 28 Mar, 2020
Review #2 received
Received 28 Mar, 2020
Review #1 received
Received 27 Mar, 2020
Reviewers invited
Invitations sent on 26 Mar, 2020
Reviewer #1 agreed
On 26 Mar, 2020
Editor assigned
On 23 Mar, 2020
Submission checks complete
On 22 Mar, 2020
Editor invited
On 22 Mar, 2020
First submitted
On 21 Mar, 2020
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A new preprint design is coming!
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See the published version of this preprint at BMC Oral Health.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Yufeng Wang
Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1417-1460
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Oral Health.
No community comments so far
Editorial decision: Accept
On 22 Aug, 2020
Editor assigned
On 03 Aug, 2020
Submission checks complete
On 02 Aug, 2020
Editor invited
On 02 Aug, 2020
Version 2
Posted 15 Jun, 2020
No comments provided
Editorial decision: Major revision
On 14 Jul, 2020
Review #2 received
Received 06 Jul, 2020
Reviewer #3 agreed
On 20 Jun, 2020
Review #1 received
Received 20 Jun, 2020
Reviewer #2 agreed
On 19 Jun, 2020
Reviewers invited
Invitations sent on 16 Jun, 2020
Reviewer #1 agreed
On 16 Jun, 2020
Editor assigned
On 10 Jun, 2020
Submission checks complete
On 09 Jun, 2020
Editor invited
On 09 Jun, 2020
No comments provided
Editorial decision: Major revision
On 13 May, 2020
Review #4 received
Received 18 Apr, 2020
Review #3 received
Received 08 Apr, 2020
Reviewer #4 agreed
On 31 Mar, 2020
Reviewer #2 agreed
On 28 Mar, 2020
Reviewer #3 agreed
On 28 Mar, 2020
Review #2 received
Received 28 Mar, 2020
Review #1 received
Received 27 Mar, 2020
Reviewers invited
Invitations sent on 26 Mar, 2020
Reviewer #1 agreed
On 26 Mar, 2020
Editor assigned
On 23 Mar, 2020
Submission checks complete
On 22 Mar, 2020
Editor invited
On 22 Mar, 2020
First submitted
On 21 Mar, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Oral Health.
Background: Oral lichen planus (OLP) is a relatively common mucocutaneous disorder, its causative factors and pathogenesis are not fully understood. The existing studies on the association between hematinic deficiencies and OLP are limited and inconsistent. The aim of this study was to assess the hematinic deficiencies in a cohort of OLP patients and evaluate the correlation between hematinic deficiencies and OLP.
Methods: 236 OLP patients and 226 age-and gender-matched healthy controls were enrolled in this study. The levels of hemoglobin (Hb), serum folate, vitamin B12 and ferritin were measured and compared between OLP patients and healthy controls. REU (reticular/hyperkeratotic, erosive/erythematous, ulcerative) scoring system was adopted and compared between the OLP patients with and without hematinic deficiencies. The correlation between hematinic deficiencies and OLP was analyzed.
Results: The frequencies of serum ferritin and vitamin B12 deficiency in OLP patients were both significantly higher than those of the healthy controls. According to gender and age, the profiles of hematinic deficiencies in OLP patients were significantly different. As for REU score, no significant difference existed between OLP patients with and without hematinic deficiencies. Both serum ferritin deficiency and serum vitamin B12 deficiency were significantly correlated with OLP. Conclusions The present study suggested a significant association between hematinic deficiencies and OLP. Iron, folate, and vitamin B12 levels in OLP patients should be monitored routinely. Further studies are warranted to explore the interactions between OLP and hematinic deficiencies.
This is a list of supplementary files associated with this preprint. Click to download.
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