We present for the first time the climatology of medium-scale traveling ionospheric disturbances (MSTIDs) by using Global Positioning System (GPS) receiver networks on geomagnetically quiet days (Kp ≤ 3) over the North African region during 2008-2016. The ionospheric Total Electron Content (TEC) were estimated from the dual-frequency GPS measurements, and the TEC perturbations (dTEC) data were derived from the estimated TEC data. We focused on the TEC perturbations (dTEC) associated MSTIDs and statistically analyzed its characteristics, occurrence rate, diurnal and seasonal behavior as well as the interannual dependence. The results show that MSTID is a local and seasonal dependence. The results also show that MSTIDs predominantly propagates towards the South (equatorward). The daytime and nighttime MSTIDs increase with solar activity, and its event period is (12 ≤ period ≤ 53 mins), while the dominant amplitude is (0.08 ≤ amp ≤ ~1.5 dTECU). The MSTIDs propagation velocity is dominantly higher at the daytime than nighttime. The study also shows that the disturbance occurrence time is more frequent within the hours of (1200 - 1600 LT), and (1000 - 1400 LT) in December solstice at daytime for stations located in the Northwest (NW) and Northeast (NE) part of the African region, respectively. While at the nighttime, the MSTIDs also exhibits variability in disturbance occurrence time around (NW: 2100–0200 LT) and (NE: 1900–0200 LT) in June solstice, but get extended to March equinox during solar maximum (2014). The mean phase velocity in daytime MSTIDs is higher than the nighttime in every season, except during June solstice.