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Research article
Bartholomew F Chukwu
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7161-4948
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Sickle cell anaemia (SCA) is characterized by attendant ischemia-reperfusion injury especially to the heart. Objectives: To compare the right ventricular function of children with SCA in steady state (subjects) with those with haemoglobin AA genotype (controls), using echocardiography.
Methods: The cross-sectional study utilized echocardiographic measurements to assess right ventricular function among children with SCA and their controls.
Results: The mean trans annular plane systolic excursion (TAPSE) in subjects, 28.24±5.23 (Z score: 0.258±1.10) was higher than that in control, 25.82±3.59 (Z score: - 0.263±0.80), and the difference in mean was statistically significant, (t=2.703, p=0.008). Significantly higher proportion of subjects with sickle cell anaemia had right ventricular dysfunction (Abnormal TAPSE), 25 (50.0% when compared with those in control, 11 (22.0%, (χ 2 =8.5, p=0.0035). A higher proportion of subjects with sickle cell anaemia (25.5%) had Pulmonary hypertension (RVP) when compared with control (2.0%) and the difference in proportions was found to be statistically significant, (χ 2 =11.668, p=0.001). The prevalence of right ventricular diastolic dysfunction in subjects was 9.8 % while control was 0%.
Conclusion Children with sickle cell anaemia present with right ventricular dysfunction. Prevalence of right ventricular systolic and diastolic dysfunction were higher in subjects. More children with genotype SS group, (25.5%) had pulmonary hypertension (RVP). Key words: Anaemia; children; Enugu; sickle cell anaemia; right ventricular function
Keywords
Anaemia, children, Enugu, sickle cell anemia, right ventricular function
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CURRENT STATUS: Published
View the published article at BMC Pediatrics.
Version 1
Posted 27 Mar, 2020
No community comments so far
Review #2 received
Received 28 Apr, 2020
Editorial decision: Major revision
On 28 Apr, 2020
Review #1 received
Received 19 Apr, 2020
Reviewer #2 agreed
On 08 Apr, 2020
Reviewer #1 agreed
On 01 Apr, 2020
Reviewers invited
Invitations sent on 30 Mar, 2020
Editor assigned
On 25 Mar, 2020
First submitted
On 24 Mar, 2020
Submission checks complete
On 24 Mar, 2020
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Subject Areas
Pediatrics
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A new preprint design is coming!
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See the published version of this preprint at BMC Pediatrics.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Bartholomew F Chukwu
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7161-4948
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pediatrics.
Version 1
Posted 27 Mar, 2020
No community comments so far
Review #2 received
Received 28 Apr, 2020
Editorial decision: Major revision
On 28 Apr, 2020
Review #1 received
Received 19 Apr, 2020
Reviewer #2 agreed
On 08 Apr, 2020
Reviewer #1 agreed
On 01 Apr, 2020
Reviewers invited
Invitations sent on 30 Mar, 2020
Editor assigned
On 25 Mar, 2020
First submitted
On 24 Mar, 2020
Submission checks complete
On 24 Mar, 2020
Editor invited
On 24 Mar, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pediatrics.
Background: Sickle cell anaemia (SCA) is characterized by attendant ischemia-reperfusion injury especially to the heart. Objectives: To compare the right ventricular function of children with SCA in steady state (subjects) with those with haemoglobin AA genotype (controls), using echocardiography.
Methods: The cross-sectional study utilized echocardiographic measurements to assess right ventricular function among children with SCA and their controls.
Results: The mean trans annular plane systolic excursion (TAPSE) in subjects, 28.24±5.23 (Z score: 0.258±1.10) was higher than that in control, 25.82±3.59 (Z score: - 0.263±0.80), and the difference in mean was statistically significant, (t=2.703, p=0.008). Significantly higher proportion of subjects with sickle cell anaemia had right ventricular dysfunction (Abnormal TAPSE), 25 (50.0% when compared with those in control, 11 (22.0%, (χ 2 =8.5, p=0.0035). A higher proportion of subjects with sickle cell anaemia (25.5%) had Pulmonary hypertension (RVP) when compared with control (2.0%) and the difference in proportions was found to be statistically significant, (χ 2 =11.668, p=0.001). The prevalence of right ventricular diastolic dysfunction in subjects was 9.8 % while control was 0%.
Conclusion Children with sickle cell anaemia present with right ventricular dysfunction. Prevalence of right ventricular systolic and diastolic dysfunction were higher in subjects. More children with genotype SS group, (25.5%) had pulmonary hypertension (RVP). Key words: Anaemia; children; Enugu; sickle cell anaemia; right ventricular function
This is a list of supplementary files associated with this preprint. Click to download.
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