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Research article
Kristin Houghton
BC Children's Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7174-1007
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Background: Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease activity, function, pain, and psychosocial stress in the two years following diagnosis in an inception cohort of children with juvenile idiopathic arthritis (JIA).
Methods: In 82 children with newly diagnosed JIA, PA levels, prospectively determined at enrollment, 12 and 24 months using the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) raw scores, were evaluated in relation to disease activity as reflected by arthritis activity (Juvenile Arthritis Disease Activity Score (JADAS-71)), function, pain, and psychosocial stresses using a linear mixed model approach. Results in the JIA cohort were compared to normative Pediatric Bone Mineral Accrual Study data derived from healthy children using z-scores.
Results: At enrollment, PA z-score levels of study participants were lower than those in the normative population (median z-score -0.356; p = 0.005). At enrollment, PA raw scores were negatively associated with the psychosocial domain of the Juvenile Arthritis Quality of Life Questionnaire (r=-0.251; p=0.023). There was a significant decline in PAQ-C/A raw scores from baseline (median and IQR: 2.6, 1.4-3.1) to 24 months (median and IQR: 2.1, 1.4-2.7; p = 0.003). The linear mixed-effect model showed that PAQ-C/A raw scores in children with JIA decreased as age, disease duration, and ESR increased. The PAQ-C/A raw scores of the participants was also negatively influenced by an increase in disease activity as measured by the JADAS-71 (p<0.001).
Conclusion: Canadian children with newly diagnosed JIA have lower PA levels than healthy children. The decline in PA levels over time was associated with disease activity and higher disease-specific psychosocial stress.
Keywords
Juvenile arthritis, physical activity, psychosocial stress
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CURRENT STATUS: Under Review
Version 1
Posted 08 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 28 Mar, 2021
Review #5 received
Received 20 Mar, 2021
Review #2 received
Received 12 Mar, 2021
Reviewer #5 agreed
On 09 Mar, 2021
Review #3 received
Received 06 Mar, 2021
Review #1 received
Received 05 Mar, 2021
Reviewer #4 agreed
On 01 Mar, 2021
Review #4 received
Received 01 Mar, 2021
Reviewer #3 agreed
On 23 Feb, 2021
Reviewer #2 agreed
On 20 Feb, 2021
Reviews received
Received 20 Feb, 2021
Reviewers invited
Invitations sent on 20 Feb, 2021
Reviewer #1 agreed
On 20 Feb, 2021
Editor assigned
On 31 Jan, 2021
Submission checks complete
On 31 Jan, 2021
Editor invited
On 31 Jan, 2021
First submitted
On 30 Jan, 2021
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Pediatric Rheumatology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Kristin Houghton
BC Children's Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7174-1007
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 08 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 28 Mar, 2021
Review #5 received
Received 20 Mar, 2021
Review #2 received
Received 12 Mar, 2021
Reviewer #5 agreed
On 09 Mar, 2021
Review #3 received
Received 06 Mar, 2021
Review #1 received
Received 05 Mar, 2021
Reviewer #4 agreed
On 01 Mar, 2021
Review #4 received
Received 01 Mar, 2021
Reviewer #3 agreed
On 23 Feb, 2021
Reviewer #2 agreed
On 20 Feb, 2021
Reviews received
Received 20 Feb, 2021
Reviewers invited
Invitations sent on 20 Feb, 2021
Reviewer #1 agreed
On 20 Feb, 2021
Editor assigned
On 31 Jan, 2021
Submission checks complete
On 31 Jan, 2021
Editor invited
On 31 Jan, 2021
First submitted
On 30 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease activity, function, pain, and psychosocial stress in the two years following diagnosis in an inception cohort of children with juvenile idiopathic arthritis (JIA).
Methods: In 82 children with newly diagnosed JIA, PA levels, prospectively determined at enrollment, 12 and 24 months using the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) raw scores, were evaluated in relation to disease activity as reflected by arthritis activity (Juvenile Arthritis Disease Activity Score (JADAS-71)), function, pain, and psychosocial stresses using a linear mixed model approach. Results in the JIA cohort were compared to normative Pediatric Bone Mineral Accrual Study data derived from healthy children using z-scores.
Results: At enrollment, PA z-score levels of study participants were lower than those in the normative population (median z-score -0.356; p = 0.005). At enrollment, PA raw scores were negatively associated with the psychosocial domain of the Juvenile Arthritis Quality of Life Questionnaire (r=-0.251; p=0.023). There was a significant decline in PAQ-C/A raw scores from baseline (median and IQR: 2.6, 1.4-3.1) to 24 months (median and IQR: 2.1, 1.4-2.7; p = 0.003). The linear mixed-effect model showed that PAQ-C/A raw scores in children with JIA decreased as age, disease duration, and ESR increased. The PAQ-C/A raw scores of the participants was also negatively influenced by an increase in disease activity as measured by the JADAS-71 (p<0.001).
Conclusion: Canadian children with newly diagnosed JIA have lower PA levels than healthy children. The decline in PA levels over time was associated with disease activity and higher disease-specific psychosocial stress.
Figure 1
Figure 2
Figure 3
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