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Khadijeh Mirzaei
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7554-8551
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation.
Results: Of 264 participants, 61.4% (n= 162), 72% (n=190), 74.6% (n=197), 68.6% (n=181), and 80.3% (n=212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P=≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR=2.80, 95%CI: 1.10-7.12, Ptrend=0.04), hypercalciuria (OR=7.44, 95%CI: 2.62-21.14, Ptrend≤0.001), hyperuricosuria (OR=2.22, 95%CI: 1.001-4.95, Ptrend=0.05), and hypocitraturia (OR=5.84, 95%CI: 2.14-15.91, Ptrend≤0.001). No association was identified between DII and hyperoxaluria.
Keywords
Dietary inflammatory index, kidney stones, hypercalciuria, hypocitraturia, hyperoxaluria, hyperuricosuria, hypercreatinuria
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CURRENT STATUS: Published
View the published article at BMC Research Notes.
No community comments so far
Editorial decision: Accept
On 24 Jul, 2020
Editor assigned
On 23 Jul, 2020
Submission checks complete
On 22 Jul, 2020
Editor invited
On 22 Jul, 2020
Version 4
Posted 21 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 21 Jul, 2020
Editor assigned
On 17 Jul, 2020
Submission checks complete
On 16 Jul, 2020
Editor invited
On 16 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 14 Jul, 2020
Review #1 received
Received 10 Jul, 2020
Reviewer #1 agreed
On 01 Jul, 2020
Reviewers invited
Invitations sent on 01 Jul, 2020
Editor assigned
On 29 Jun, 2020
Submission checks complete
On 28 Jun, 2020
Editor invited
On 28 Jun, 2020
No comments provided
Editorial decision: Minor revision
On 24 Jun, 2020
Review #1 received
Received 20 Jun, 2020
Reviewer #1 agreed
On 18 Jun, 2020
Reviewers invited
Invitations sent on 17 Jun, 2020
Editor assigned
On 15 Jun, 2020
Submission checks complete
On 14 Jun, 2020
Editor invited
On 14 Jun, 2020
No comments provided
Editorial decision: Major revision
On 08 Apr, 2020
Reviewer #1 agreed
On 04 Apr, 2020
Review #1 received
Received 04 Apr, 2020
Reviewers invited
Invitations sent on 01 Apr, 2020
Editor assigned
On 28 Mar, 2020
Submission checks complete
On 27 Mar, 2020
Editor invited
On 27 Mar, 2020
First submitted
On 25 Mar, 2020
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A new preprint design is coming!
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See the published version of this preprint at BMC Research Notes.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
Khadijeh Mirzaei
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7554-8551
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Research Notes.
No community comments so far
Editorial decision: Accept
On 24 Jul, 2020
Editor assigned
On 23 Jul, 2020
Submission checks complete
On 22 Jul, 2020
Editor invited
On 22 Jul, 2020
Version 4
Posted 21 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 21 Jul, 2020
Editor assigned
On 17 Jul, 2020
Submission checks complete
On 16 Jul, 2020
Editor invited
On 16 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 14 Jul, 2020
Review #1 received
Received 10 Jul, 2020
Reviewer #1 agreed
On 01 Jul, 2020
Reviewers invited
Invitations sent on 01 Jul, 2020
Editor assigned
On 29 Jun, 2020
Submission checks complete
On 28 Jun, 2020
Editor invited
On 28 Jun, 2020
No comments provided
Editorial decision: Minor revision
On 24 Jun, 2020
Review #1 received
Received 20 Jun, 2020
Reviewer #1 agreed
On 18 Jun, 2020
Reviewers invited
Invitations sent on 17 Jun, 2020
Editor assigned
On 15 Jun, 2020
Submission checks complete
On 14 Jun, 2020
Editor invited
On 14 Jun, 2020
No comments provided
Editorial decision: Major revision
On 08 Apr, 2020
Reviewer #1 agreed
On 04 Apr, 2020
Review #1 received
Received 04 Apr, 2020
Reviewers invited
Invitations sent on 01 Apr, 2020
Editor assigned
On 28 Mar, 2020
Submission checks complete
On 27 Mar, 2020
Editor invited
On 27 Mar, 2020
First submitted
On 25 Mar, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Research Notes.
Objective: Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation.
Results: Of 264 participants, 61.4% (n= 162), 72% (n=190), 74.6% (n=197), 68.6% (n=181), and 80.3% (n=212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P=≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR=2.80, 95%CI: 1.10-7.12, Ptrend=0.04), hypercalciuria (OR=7.44, 95%CI: 2.62-21.14, Ptrend≤0.001), hyperuricosuria (OR=2.22, 95%CI: 1.001-4.95, Ptrend=0.05), and hypocitraturia (OR=5.84, 95%CI: 2.14-15.91, Ptrend≤0.001). No association was identified between DII and hyperoxaluria.
This is a list of supplementary files associated with this preprint. Click to download.
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