Oral cancer has plagued the majority of the world as one of the most prevalent cancers. The main reason often highlighted is the high usage of tobacco, which has been reported to be the main cause of oral cancer, and the lack of proper health and sexual h+ygiene. This often leads to HPV infection which has been seen as one of the leading causes of oral cancer. Numerous reports have identified the dysregulation of genes as one of the major causes at play in the mechanisms of cancer. A detailed investigation of the dysregulated gene expressions and the pathways shed some light on the mechanistic properties behind cancer, which can potentially lead to a viable approach for biomarker identification and further research.