Extended endoscopic transsphenoidal surgery with total cyst wall decollement for suprasellar cystic craniopharyngioma

doi:10.21203/rs.3.rs-1980571/v1

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Extended endoscopic transsphenoidal surgery with total cyst wall decollement for suprasellar cystic craniopharyngioma

https://doi.org/10.21203/rs.3.rs-1980571/v1

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Background: For most cystic craniopharyngiomas, intracapsular debulking is a good strategy to get a large operation space and protect vital structures. However, this surgical strategy may lead to the residual and recurrence of the tumor capsule wall. Therefore, there is an urgent need for a new surgical strategy without residual capsule walls for the removal of cystic craniopharyngiomas.

Case Report: We reviewed a 45-year-old male with vision loss and visual field defects, whose head MRI revealed a suprasellar cystic lesion. The patient underwent extended endoscopic transsphenoidal surgery. The surgical strategy of total cystic wall decollement was adopted, which was that the lesion surrounded by the capsule was completely separated from the surrounding tissue without destroying the capsule and maintaining the tension of the capsule. The lesion was totally resected and pathological findings confirmed the diagnosis of craniopharyngioma. After the operation, both the visual acuity and pituitary function were significantly improved. In addition, he suffered from transient diabetes insipidus, which was subsequently relieved. During the 33-month follow-up, there was no tumor recurrence.

Conclusion: Compared with the traditional surgical strategy of intracapsular debulking, the surgical strategy of total cystic wall decollement has the advantages of less residual tumor capsule, low tumor recurrence rate, etc. Therefore, for cystic craniopharyngiomas with an intact capsule or even other cystic tumors with an intact capsule, the surgical strategy of total cystic wall decollement may be an effective surgical strategy to reduce tumor recurrence.

craniopharyngioma

extended endoscopic transsphenoidal surgery

total cystic wall

Craniopharyngiomas are rare congenital benign tumors originating from remnants of the pouch of Rathke [1]. The incidence rate of craniopharyngioma is only 0.13 cases per 100000 people and presents a bimodal age distribution, that is, the peak age of incidence is mainly concentrated in 5–14 years old (children) and 50–74 years old (elderly) [2]. Due to the space-occupying effect, the common symptoms of craniopharyngioma are visual impairment, hypopituitarism, and symptoms of increased intracranial pressure (headache and vomiting), etc. According to the tumor location, craniopharyngiomas can be divided into pure intrasellar, intrasellar, suprasellar, and pure suprasellar types [3]. While according to the tumor texture, craniopharyngiomas can be divided into cystic, solid, and mixed types [4]. Generally, surgery is the first choice for the treatment of craniopharyngiomas. Because craniopharyngiomas are located in the skull base, the endoscopic endonasal transsphenoidal approach (EETA) is very suitable for resection of craniopharyngiomas and has become the standard surgical method. At present, the common surgical strategy for the removal of cystic craniopharyngiomas is intracapsular debulking, which is conducive to getting a large operation space and protecting important structures, such as the hypothalamus, pituitary gland, optic nerve, etc. However, this surgical strategy also has limitations, such as tumor residual and tumor recurrence, etc. To break through these limitations, we proposed a surgical strategy of total cystic wall decollement, which is that the tumor surrounded by the capsule is completely separated from the surrounding tissue without destroying the capsule and maintaining the tension of the capsule. In this paper, we report a case of suprasellar cystic craniopharyngioma who underwent extended endoscopic transsphenoidal surgery (EETS) with total cystic wall decollement.

History and examination

A 45-year-old male went to other hospital for examination due to vision loss and visual field defect. Cranial MRI revealed a suprasellar cystic lesion, and then he was referred to our department. The preoperative clinical examination suggested 1-meter blurred vision and temporal visual field defects in both eyes, while the hormone examination indicated pituitary dysfunction. Figure 1a and 1b are the preoperative sagittal and coronal T1-weighted MRI, respectively, presenting a suprasellar cystic lesion, marginal calcification, pituitary compression, and hypointense, which all suggest that the lesion is a suprasellar cystic craniopharyngioma.

Operation

Under general anesthesia, the patient was placed in the supine position with the head tilted slightly to the right. Firstly, the surface projection of the tumor was located under neuronavigation and the endoscopic was placed along the right nasal cavity. Under the endoscopic, the middle turbinate resection was used to reveal the opening of the right sphenoid sinus, and the dura mater and intercavernous sinus were exposed, as shown in Fig. 2a. Then, the dura mater was opened, and the cavernous sinus was coagulated, the arachnoid above the pituitary stalk was dissected, and the cystic lesions containing straw yellow cystic fluid were displayed, as shown in Fig. 2b. After the tumor was visible, the tumor and surrounding tissues were separated along the tumor capsule wall without destroying the tumor capsule wall and maintaining the integrity of the capsule wall. During the separation process, we found that the lateral capsule wall of the tumor adhered to the optic chiasma, as shown in Fig. 2c, and the deep capsule wall of the tumor adhered to the bottom of the third ventricle, as shown in Fig. 2d. The cystic wall of the tumor was slowly separated from the adhesive tissue. By slowly separating the tumor capsule wall and adhesive tissue, the tumor wrapped by the capsule wall was completely stripped off. Figure 2e shows that the tumor originated from the pituitary stalk. To achieve gross total resection (GTR), the tumor was removed from the pituitary stalk, as shown in Fig. 2f. During the operation, we did not destroy the tumor capsule, maintained the tension of the tumor capsule, and completely stripped the capsule. Finally, the skull base was repaired with a vascular nasal septal mucosal flap, gelatin sponge, and artificial dura mater. In particular, it should be pointed out that in the process of peeling off the tumor capsule wall to cutting off the tumor origin, the capsule wall is always kept intact, so that it has enough tension, which is more conducive to the separation of the capsule wall from the surrounding adhesive tissue with no residual tumor.

After surgery, his vital signs were stable and pathological findings confirmed the diagnosis of craniopharyngioma. Clinical examination indicated visual disturbance improved, and hormone examination indicated mild hypopituitarism. On the third day after surgery, cranial MRI showed that there was no secondary intracranial hemorrhage and the tumor was grossly totally resected (Fig. 1c-1d). During hospitalization, he suffered transient diabetes insipidus, which was relieved at a 4-week follow-up. During the 33-month follow-up, there was no tumor recurrence.

Craniopharyngioma is a rare benign tumor originating from remnants of the pouch of Rathke, which can lead to increased intracranial pressure, optic nerve compression, and pituitary stalk compression, thus presenting clinical symptoms such as headache, vomiting, visual impairment, pituitary dysfunction, etc [5]. Regardless of the type of craniopharyngioma, surgery is always the first choice. The EETA is not only suitable for the treatment of skull base lesions but also has an excellent view, which makes it a standard method for the removal of craniopharyngiomas [6–8]. For cystic craniopharyngiomas, intracapsular debulking is the most commonly used surgical strategy, and the specific steps are as follows: first, the tumor capsule is opened, then the cystic fluid is aspirated, and finally, the tumor capsule and neurovascular structure are separated and aspirated. The surgical strategy of intracapsular debulking has many advantages of simple operation, large operation space, protection of blood vessels and surrounding tissues, etc., which has been widely used and recognized by surgeons.

Table 1 shows the cases of cystic craniopharyngioma resected by surgery combined with intracapsular debulking of surgical strategy in recent years, including the number of patients, tumor location, surgical approach, and GTR rate, follow-up time, recurrence, postoperative complications, adjuvant therapy, etc [9–32]. It can be seen from Table 1, most of the cystic craniopharyngiomas were located in the sellar and suprasellar regions, and occasionally in the intraventricular, orbital cavity, and foramen magnum. The surgical approaches for craniopharyngioma are the endoscopic transorbital eyelid approach (ETEA), endoscopic transcortical transventricular approach (ETTA), endoscopic endonasal transsphenoidal approach (EETA), fronto-basal interhemispheric approach (FBIA), sublabial-transseptal approach (STA), microsurgery pterional approach (MPA), microsurgery transsphenoidal approach (MTA) and subfrontal approach (SA), etc. The GTR rate ranged from 35.2–100%, and the recurrence rate ranged from 0 to 82.0% [11, 21]. Im et al. reported that GTR was achieved in all 6 patients, but one patient relapsed, which may be due to a small amount of residual cyst wall of the tumor not found by intraoperative endoscopic images and postoperative cranial MRI [29]. More residual cyst wall leads to a higher recurrence rate and reflects the fact that the surgical strategy of intracapsular debulking brings a higher risk of residual tumors and tumor recurrence. However, Zhu et al. reported 8 patients (72.7%) who obtained GTR, but no patients relapsed, which may be due to the short follow-up period (18.5 months) [14]. To prevent the recurrence caused by residual tumor, postoperative radiotherapy has also become a necessary adjuvant treatment and is widely used [12, 17, 26, 27, 30]. Unfortunately, although postoperative adjuvant radiotherapy has been performed, there will still be tumor recurrence. Therefore, some patients must undergo reoperation or multiple operations [13, 24], which brings huge pain and economic burden to patients. The main postoperative complications were cerebrospinal fluid leakage (CSFL), diabetes insipidus (DI), cerebral meningitis, hydrocephalus, hyposmia, intracranial infection, etc. Among them, CSFL and new onset DI were relatively high [14, 33], which may be caused by surgery and the deficiency of the pituitary hormone. In addition, the occurrence of meningitis and intracranial infection may also be attributed to the release of cystic fluid. Considering the GTR, residual cyst wall, recurrence, and postoperative complications, intracapsular debulking is not a perfect surgical strategy. The main problem of intracapsular debulking is that once the tumor capsule is opened, the tension of the tumor capsule wall disappears, making it difficult for the tumor capsule to completely separate from the surrounding normal tissues, resulting in the residual and recurrence of the tumor capsule wall. Therefore, we propose a surgical strategy of total cyst wall decollement, that is, the tumor around the cyst wall is completely separated from the surrounding tissues, without destroying the cyst wall, and maintaining the tension of the cyst wall, which is conducive to the separation of the tumor from the surrounding tissues.

In this paper, a 45-year-old male with suprasellar cystic craniopharyngioma who underwent EETS with total cyst wall decollement. During the operation, the tumor wrapped in the capsule wall is completely stripped off without destroying the tumor capsule and maintaining the tension of the tumor capsule. Finally, the tumor was cut from the pituitary stalk to achieve total tumor resection. After the operation, the visual acuity and pituitary function were greatly improved. There was no CSFL, meningitis, and other serious complications. Only transient DI appeared and was relieved later. There was no adjuvant radiotherapy after the operation. During the 33-month follow-up, there was no tumor recurrence. These results show that the EETS with total cyst wall decollement is a safe and effective surgical method for suprasellar cystic craniopharyngiomas or even other cystic tumors with an intact capsule.

Table 1

Reported cases of cystic craniopharyngioma treated by surgery
Year	Authors	No. cases	location	Surgical approach	GTR (%)	Mean follow-up (months)	Recurrence (%)	Complications	Adjuvant therapy	Ref.
2022	Vitulli et al.	1	Orbital cavity	ETEA	1(100%)	3	0	No	No	[9]
2021	Noureldine et al.	1	Sellar and suprasellar	ETTA	1(100%)	24	0	No	No	[10]
2021	Chen et al.	2	Foramen magnum	Hole	2(100%)	54	0	No	No	[11]
2019	Frio et al.	11	/	Hole	/	41.4	3(27.3%)	CSFL, HCP	RO, RT	[12]
2017	Lauretti et al.	8	/	Hole	/	56	2(20%)	CSFL	RO	[13]
2017	Zhu et al.	11	/	FBIA	8(72.7%)	18.5	0	DI	No	[14]
2017	Moore et al.	2	Suprasellar	Hole	2(100%)	24	0	No	No	[15]
2016	Ichikawa et al.	4	Sellar and suprasellar	FBIA	4(100%)	33	1(25%)	No	No	[16]
2015	Takano et al.	9	Sellar and suprasellar	Hole	/	72.9	1(11.1%)	No	RO, RT	[17]
2015	Shukla et al.	3	Suprasellar	ETTA	/	9	0	No	RT	[18]
2015	Prabhu et al.	1	Suprasellar	EETA	1(100%)	/	/	No	/	[19]
2011	Park et al.	13	/	Hole	/	32	7(53.8%)	No	RT	[20]
2009	Schubert et al.	17	/	MPA	6(35.2%)	66	14(82%)	/	RO, RT	[21]
2009	Filis et al.	1	Sellar and suprasellar	MPA	1(100%)	24	0	No	No	[22]
2008	Cappabianca et al.	1	Intraventricular	Hole	1(100%)	36	0	No	No	[23]
2006	Rudnick et al.	1	Sellar	STA	/	28	0	No	RO	[24]
2006	Berlis et al.	1	/	Hole	/	6	0	No	No	[25]
2005	Kamikawa et al.	1	Suprasellar	Hole	/	/	/	No	RT	[26]
2004	Nakahara et al.	5	Suprasellar	Hole	/	10.8	1(20%)	No	RT	[27]
2004	Locatelli et al.	5	/	EETA	/	48	1(20%)	No	No	[28]
2003	Im et al.	6	Sellar	MTA	6(100%)	26	1(16%)	DI	RO	[29]
2002	Joki et al.	1	Sellar	Hole	0	6	0	No	RT	[30]
2001	Nakamizo et al.	1	Intraventricular	Hole	/	24	0	No	No	[31]
2001	Buhl et al.	1	Infrasellar and suprasellar	SA	/	12	0	No	No	[32]
CSFL, cerebrospinal fluid leakage; DI, diabetes insipidus; ETEA, endoscopic transorbital eyelid approach; ETTA, endoscopic transcortical transventricular approach; EETA, endoscopic endonasal transsphenoidal approach; FBIA, fronto-basal interhemispheric approach; HCP, hydrocephalus; MPA, microsurgery pterional approach; MTA, microsurgery transsphenoidal approach; RO, re-operation; RT, radiotherapy; STA, sublabial-transseptal approach; SA, subfrontal approach.

We retrospectively analyzed a case with suprasellar cystic craniopharyngioma treated by extended endoscopic transsphenoidal surgery. The tumor was achieved GTR with no recurrence during follow-up. After the operation, both the visual acuity and pituitary function were significantly improved and there were no serious complications. A surgical strategy of total cyst wall decollement was adopted during the operation. Specifically, the tumor around the cyst wall is completely separated from the surrounding tissue without destroying the cyst wall and maintaining the tension of the cyst wall. Compared to the common surgical strategy of intracapsular debulking, which may lead to residual and recurrence of the tumor capsule wall, the surgical strategy of total cystic wall decollement has the advantage of obtaining a higher resection rate and lower recurrence rate and preservation of pituitary function. Further, the surgical strategy of total cyst wall decollement may also be applicable to other cystic tumors with an intact capsule.

Ethical approval and consent to participate

This article was approved by the committee ethics of Chongqing General Hospital, and informed consent was obtained from all individual participants included in the study.

Human and animal ethics

Not applicable.

Consent to publish

The authors affirm that human research participants provided informed consent for publication of the images in Figure1 a-d and Figure2 a-f.

Availability of supporting data

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Competing interests

The authors have no relevant financial or non-financial interests to disclose.

Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Author contributions

Jie Liu, Junwei Wang, Pan Wang, Chao Tang, and Haotian Jiang contributed to the study conception and design. Material preparation, data collection and analysis were performed by Jie Liu, Gang Zhang, Xiaorong Tan, Jinyu Pan, Nan Wu. The first draft of the manuscript was written by Jie Liu and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Acknowledgments

Not applicable.

Authors' information

Jie Liu, Junwei Wang, Pan Wang, Chao Tang, Haotian Jiang, Gang Zhang, Xiaorong Tan, Jinyu Pan, Nan Wu*

Department of Neurosurgery, Chongqing General Hospital, NO.118, Xingguang Avenue, Liangjiang New Aera, Chongqing 401147, China.

Corresponding author: Nan Wu, Department of Neurosurgery, Chongqing General Hospital, NO.118, Xingguang Avenue, Liangjiang New Aera, Chongqing 401147, China. E-mail: [email protected]

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No competing interests reported.

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Extended endoscopic transsphenoidal surgery with total cyst wall decollement for suprasellar cystic craniopharyngioma

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