Analysis of the clinical risk factors of re-fracture after osteoporotic fracture

Background To investigate the clinical risk factors of patients with osteoporotic fracture and re-fracture. Methods A total of 96 patients with osteoporotic fractures and re-fractures who were treated in the relevant department of our hospital from January 2017 to December 2018 were selected as the research objects. By comparing the basic clinical situation of these two groups Analysis to explore the main risk factors after refracture. Results Through statistical analysis of clinical data, it was found that gender, age, the time from lying down to standing, and the bone mineral density T value were all clinical risk factors for refracture. Women who lie prolonged to stand have a higher risk of re-fracture. Conclusions The risk factors of re-fracture after treatment in elderly patients with osteoporotic fractures are many and complex. Early investigation and targeted preventive measures can be of great significance to reduce the incidence of re-fractures.


Background
Osteoporosis is a disease characterized by low bone mass, destruction of bone microstructure, increased bone fragility, decreased bone strength and ease of fracturing. The disease has become a leading cause of morbidity and mortality among the elderly [1]. The prevalence of osteoporosis ranges between 13 to 18% among women aged above 50 years and 3 to 6% in men. The bone mass of women and men over 50 years old in Europe. The prevalence of osteoporosis was 21% and 6%, respectively. The prevalence of osteoporosis in women in the United States and Europe is about three times that of men. In China, the prevalence of osteoporosis based on the bone mineral density of the vertebral body and femoral neck was 20.7% in women and 14.4% in men. Compared with that of the United States and Europe, the prevalence of osteoporosis among men in China is relatively higher.
With the rise of China's aging population and life expectancy, the number of osteoporosis patients will continue to increase. There are approximately 69.44 million people aged over 50 years that are living with osteoporosis in China. It is estimated that the number of osteoporosis patients will increase from the current 286.6 million to 533.3 million by 2050 [4,5]. 3 The onset of osteoporosis is often insidious with no obvious symptoms. When the disease progresses to a symptomatic phase, its main clinical manifestations include the presence of pain, a hunchback, and height reduction. Severe cases of osteoporosis can lead to fractures. An osteoporotic fracture can occur during the performance of activities daily living or as a result of minor trauma. It commonly occurs in the vertebral column, hips, distal radius and on the proximal shaft of the humerus. Research has shown that about 50% of women and 22% of men above the age of 50 years will suffer from an osteoporosis fracture [6,7]. In 2010, the total prevalence rate of osteoporosis fracture in people over 50 years old in China was 26.6%. The risk of recurrent or second fractures among patients with osteoporotic fractures is quite high (Klotzbuecher et al. year). The meta-analysis of 49 studies on the risk of re-fracture after osteoporotic fractures from different countries and regions revealed that the risk in these patients was double that observed in patients with first-time fractures (95% CI = 1.7-2.4) [8]. Kanis et al. In addition, the results from a recent meta-analysis (11 studies) also showed that recurring fractures were 1.86 times more likely to happen in osteoporotic patients compared to that of patients without a history of fractures in Canada, Europe, and other countries(95% CI = 1.75-1.98) [9,10]. Furthermore, the predisposition to re-fracturing varies from site to site. Some studies have shown that the risk of a second hip fracture is 2 to 2.5 times likely to happen while that of a vertebral fracture and that of a distal radius fracture are 5 and 5.67 times likely to happen, respectively [11,12].
Osteoporotic fractures, especially the hip fractures, are often brittle and complete leading to significant residual disability, mental health problems as well as increased mortality. Hip fractures are the most serious consequence of osteoporosis and account for hospitalizations in 18.2% of osteoporotic fracture patients. The mortality rate during the first year after hip fracture ranges from 20 to 25% (). More than half of the survivors experience different degrees of disability, activity limitations and reduced quality of life. Due to poor bone quality (low bone density and strength, increased bone fragility), dwindling calcium and vitamin D levels and poor vision, the elderly are prone to falls that predispose them to fractures and associated mortality.  The demographic and clinical treatment data of the two groups were collected and this included sex, age, history, time of illness, bone density T-score value, Charlson Comorbidity Index (CCI) and the interval between standing and lying movements. The data was used to determine the high-risk factors that are of clinical significance.

Statistical analysis:
SPSS 16.0 statistical software () was used to analyze the above data. The measurement data was expressed as X ± s, and a Chi-squared test was carried to test relationships between categorical variables. The difference was considered statistically significant when P < 0.05.

Inclusion criteria:
All patients, whether they just had their first fracture or a re-fracture and are over 55 years old. They should have a diagnosis of osteoporosis; the fracture occurs at any of the following sites: the distal radius, the proximal humerus, the vertebral body, the proximal femur and the acetabulum of the hip bone; the fracture causes are falling injuries. Exclusion criteria: if the fracture phenomenon was caused by severe violence, such as traffic accidents; patients who have bone metabolism-related diseases; patients receiving radiotherapy and chemotherapy; patients taking or who have taken anticoagulants and other fracture-related drugs and food.

The demographic characteristics of osteoporosis patients
The demographic characteristics of osteoporosis patients in this study are shown in Table 1. There were 48 patients with one-time osteoporotic fractures (11 males, average age of 73.1 ± 6.35 and 37 females with an average age of 72.5 ± 6.18). There also 48 patients with recurrent fractures (18 males had second after osteoporosis with mean age 74.1 ± 4.62, and 30 females, mean age was 75.13 ± 5.08). In the group, fifteen patients were aged between 60 and 70, 33 were over 70 while in the group 12 patients aged 60 to70 and 36 were over 70 years old. The analysis results of the above data after independent sample t-test are shown in Table 1, 2

Discussion
The statistical analysis showed that the majority of the patients who qualified for inclusion in this study were over 70 years old, and most were female. The number of female patients was nearly twice that of the male patients, which is consistent with the domestic research results on the prevalence of osteoporosis (). In the United States in 2004 and Europe in 2010, women were about three times more likely to suffer from osteoporosis than men. Compared with the United States and Europe, the proportion of male patients in China is higher. The possible reason could be Chinese men's habits such as (excessive) drinking and smoking as well as high pressure might be causing the increased risk of fracture, but the specific reason needs to be further clarified [13]. The common downstream 7 complications arising from these habits that predispose to fractures in osteoporosis patients include hypertension, cerebrovascular disease, diabetes, chronic lung disease, chronic heart disease, and peripheral vascular disease.
Among the first time osteoporotic fracture patients included in this study, the majority of them had vertebral and femoral fractures. The patients with osteoporotic fractures for the second time also presented with vertebral, femoral and radial fractures, in that order of decreasing frequency. The main fracture sites were concentrated in the femur or vertebral bodies. These sites not only affects the but also affects the overall balance ability of patients. The decreased ability to maintain balance makes it easy for the patients to fall again, resulting in a second fracture. This result is consistent with the international "prevention and treatment of bone". According to the clinical practice guide of osteoporosis (), the common fracture sites are the spine, hip, distal radius, and proximal humerus. In this study, we found that the mean BMD T-score of patients with first-time osteoporotic fractures was significantly lower than that of patients with second osteoporotic fractures. Patients with osteoporosis fracture. In the 65 year old group, for every 1 SD decrease in BMD, osteoporotic bone was found in men. The risk of fracture increased 1.41 times (1.33-1.51) and 1.38 times (1.28-1.41) in women. Two groups of patients' CCI scores were comparable, with more than three-quarters of the patients having 0, 1 and 2 scores. According to the experimental results, 30 patients (62.5%) in the first-time fracture group spent 15-20 s while 18 patients spent more than 20 s to ambulate from lying to standing. 15 patients with osteoporotic repeat fractures also spent 15-20 s while 11 spent more than 20 s. The differences between groups were, however, not statistically significant at p =0.05. Although there was a general tendency towards a rise in the number of patients with better outcomes (reduced ambulation time), the small sample could have reduced the statistical power required to capture the significant changes. In healthy patients, the time from lying down to standing is short since the body functions would be normal. However, the time from lying down to standing in weak patients is longer and is related to the reduced physical strength of the patient. patients not only have serious physiological pain, but they also suffer from psychological trauma. This predisposes them to avoidance behaviors that exacerbate their anxieties. These patients become extremely afraid of walking normally, thereby increasing the risk for and incidence of secondary fractures [14,15].
There are many other factors other than age and sex, such as long transition time from lying to standing position and low BDM T-scores that influence predisposition to secondary fractures and warrant attention. More specific preventive measures and careful explanation of osteoporosis to middle-aged and old people should be carried to reduce the incidence of these debilitating fractures.
It is also crucial to strengthen awareness of fracture recurrence among patients with osteoporosis.
Clinicians and biomedical researchers should continue to study various related risk factors and actively seek to reduce the incidence of fracture recurrence, and improve the quality of life of patients.

Conclusion
The clinical data and personal information of 48 patients with osteoporosis fracture and 48 patients with re fracture after osteoporosis were analyzed. Through the statistics of personal information of the two groups of patients, it is found that the proportion of female patients in the first place is much 9 larger than that of male patients, and the second age is more than 60 years old, mainly distributed over 70 years old. When identifying the specific location of fracture, there are four kinds of fracture: femoral fracture, humeral fracture, radial fracture and vertebral body fracture. Fracture, through the statistics of the fracture site of patients, we found that the overall frequency of four kinds of fractures is similar. In the patients with osteoporosis fracture and the patients with re fracture after osteoporosis fracture, vertebral fracture has a slightly higher proportion, but the overall difference is not significant, and the analysis found that there is no statistical significance. Through t-test and chi square test of t-value of BMD, Charlson's index of comorbidity and time between lying and standing, we found that the mean value of t-value of BMD in patients with osteoporosis was significantly different from that in patients with osteoporotic re fracture, and chi square test found that there was statistical significance (P < 0.05), and the time between lying and standing in patients with osteoporotic re fracture was significantly different (P < 0.05) It was significantly longer than that of osteoporotic fracture patients.

Declarations
Ethics approval and consent to participate: The consent I obtained from study participants was verbal which was approved by the Yijishan ethics committee. A patient with a radial fracture. The patient got radius fracture with osteoporosis. He got a internal fixation with plate.

Supplementary Files
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