Variables
|
Case 1
|
Case 2
|
Case 3
|
Case 4
|
Case 5
|
· Demographic characteristics
|
Age
|
34
|
34
|
35
|
31
|
22
|
Gender
|
Male
|
Male
|
Male
|
Female
|
Female
|
Ethnicity
|
Indian
|
Nigerian
|
Nigerian
|
Nigerian
|
Nigerian
|
Occupation
|
Data Analyst
|
Chef
|
Businessman
|
Cloth factory worker
|
Student
|
International travel history in last 21 days before onset of symptoms
|
No
|
No
|
No
|
No
|
No
|
Sexual contact in last 21 days before onset of symptoms
|
Denied
|
Yes (Heterosexual)
|
Yes (Heterosexual)
|
Denied
|
Yes (Heterosexual)
|
Small pox/Monkeypox vaccination received
|
No
|
No
|
No
|
No
|
No
|
|
- A. Post onset day of illness
|
14
|
07
|
10
|
05
|
05
|
|
June 23, 2022
|
August 1, 2022
|
August 3, 2022
|
August 5, 2022
|
August 12, 2022
|
|
|
|
|
|
|
Lesion type on presentation
|
Vesicle, Pustule
|
Vesicle, Pustule, Crust
|
Vesicle, Pustule, Crust
|
Papule, Vesicle
|
Vesicle, Pustule
|
No of lesions
|
20-50
|
51-100
|
51-100
|
20-50
|
20-50
|
No of sites
|
09
|
10
|
08
|
07
|
07
|
Sites of typical lesions
|
Genitalia, bilateral palm, bilateral upper limb, scalp, trunk, and bilateral lower limb
|
Groin, legs, arms, trunk, back, face, scalp, palm, and sole
|
Groin, genitals, leg, arm, trunk, face, scalp, palm, and soles
|
Bilateral arms, trunk, genitalia, face, and scalp
|
Genitals, perianal, upper limb, trunk, face, lower limb
|
Mucocutaneous manifestations
|
None
|
Two lesions (0.5x0.5cm) with erythematous margin on oral cavity
|
None
|
Two Lesions under the mucosa of lower lip
|
One lesion over right oral commissure
|
Fever
|
Yes
|
Yes
|
Yes
|
Yes (associated with chills and rigors)
|
Yes
|
Headache
|
Yes
|
No
|
No
|
No
|
No
|
Fatigue/lethargy
|
No
|
No
|
No
|
No
|
No
|
Myalgia
|
Yes
|
Yes
|
Yes
|
Yes
|
Yes
|
Arthralgia
|
No
|
No
|
No
|
No
|
No
|
Back pain
|
No
|
No
|
No
|
No
|
No
|
- Lymphadenopathy [firm and nontender]
|
|
|
|
|
|
Axillary
|
No
|
No
|
No
|
No
|
No
|
Cervical
|
No
|
No
|
No
|
No
|
Yes (Bilateral; 2X2 cm)
|
Inguinal
|
No
|
Yes (Right;2x2cm)
|
Yes (Bilateral; 2x2cm)
|
Yes (Bilateral; 1.5x2cm)
|
Yes (Bilateral; 1.5x2cm)
|
Submental
|
No
|
Yes (Bilateral;1x1cm)
|
No
|
No
|
No
|
Retro-auricular
|
No
|
Yes (Bilateral;1x1cm)
|
No
|
No
|
No
|
Sub-mandibular
|
No
|
No
|
Yes (Bilateral;1x1cm)
|
No
|
No
|
|
|
|
|
|
|
Chest Pain
|
No
|
No
|
No
|
Yes
|
No
|
Rectal pain or pain on defecation
|
No
|
No
|
No
|
No
|
No
|
Sore throat
|
No
|
No
|
No
|
Yes
|
Yes
|
Penile swelling
|
No
|
No
|
No
|
N.A
|
N.A
|
Scrotal swelling
|
No
|
No
|
Yes
|
N.A
|
N.A
|
Vaginal swelling
|
N.A
|
N.A
|
N.A
|
Yes
|
No
|
Dysuria
|
No
|
Yes
|
No
|
Yes
|
No
|
Difficulty in deglutition
|
No
|
No
|
No
|
Yes
|
Yes
|
E. Co-morbidities
|
No
|
No
|
No
|
No
|
No
|
· Other Sexually transmitted Infections
|
HIV antibodies
|
Negative
|
Negative
|
Negative
|
Negative
|
Negative
|
Hepatitis B virus surface antigen
|
Negative
|
Positive
|
Negative
|
Negative
|
Negative
|
HCV RNA
|
Negative
|
Negative
|
Negative
|
Negative
|
Negative
|
Syphilis
|
Negative
|
Negative
|
Negative
|
Negative
|
Negative
|
HSV-1 and 2 DNA
|
Negative
|
Negative
|
Negative
|
Negative
|
Negative
|
VZV DNA
|
Negative
|
Negative
|
Negative
|
Negative
|
Negative
|
· Laboratory diagnosis on clinical specimens (Ct values)
|
OPS
|
POD 14 (Negative),
POD 18 (Negative),
POD 22 (Negative)
|
POD 7 (37.27),
POD 11 (Negative),
POD 17 (Negative)
POD 21 (Negative)
|
POD 10 (31.71),
POD 15 (Negative),
POD 20 (Negative)
POD 24 (Negative)
|
POD 5 (27.37),
POD 9 (38.72),
POD 13 (Negative)
POD 17 (Negative)
|
POD 5 (31.85),
POD 9 (31.81),
POD 13 (Negative)
|
NPS
|
POD 14 (33.18),
POD 18 (Negative),
POD 22 (Negative)
|
POD 7 (35.74),
POD 11 (33.90),
POD 17 (Negative)
POD 21 (Negative)
|
POD 10 (31.71),
POD 15 (36.24),
POD 20 (Negative)
POD 24 (Negative)
|
POD 5 (27.37),
POD 9 (37.71),
POD 13 (37.03)
POD 17 (Negative)
|
POD 5 (Negative),
POD 9 (32.92),
POD 13 (35.28)
|
EDTA blood
|
POD 14 (Negative),
POD 18 (Negative),
POD 22 (Negative)
|
POD 7 (Negative),
POD 11 (Negative),
POD 17 (Negative)
POD 21 (Negative)
|
POD 10 (Negative),
POD 15 (Negative),
POD 20 (Negative)
POD 24 (Negative)
|
POD 5 (33.19),
POD 9 (Negative),
POD 13 (Negative)
POD 17 (Negative)
|
POD 5 (Negative),
POD 9 (Negative),
POD 13 (Negative)
|
Serum
|
POD 14 (38.24),
POD 18 (Negative),
POD 22 (Negative)
|
POD 7 (Negative),
POD 11 (Negative),
POD 17 (Negative)
POD 21 (Negative)
|
POD 10 (Negative),
POD 15 (Negative),
POD 20 (Negative)
POD 24 (Negative)
|
POD 5 (Negative),
POD 9 (Negative),
POD 13 (Negative)
POD 17 (Negative)
|
POD 5 (Negative),
POD 9 (Negative),
POD 13 (Negative)
|
Urine
|
POD 14 (Not tested),
POD 18 (Negative),
POD 22 (Negative)
|
POD 7 (29.74),
POD 11 (32.93),
POD 17 (35.71)
POD 21 (Negative)
|
POD 10 (34.52),
POD 15 (33.11),
POD 20 (Negative)
POD 24 (Negative)
|
POD 5 (21.6),
POD 9 (27.35),
POD 13 (Not done)
POD 17 (Negative)
|
POD 5 (30.23),
POD 9 (Negative),
POD 13 (Negative)
|
Lesion base
|
POD 14 (24.01),
POD 18 (Negative),
POD 22 (Negative)
|
POD 7 (26.26),
POD 11 (not collected),
POD 17 (35.12)
POD 21 (Negative)
|
POD 10 (26.63),
POD 15 (30.49),
POD 20 (32.70)
POD 24 (Negative)
|
POD 5 (Negative),
POD 9 (30.72),
POD 13 (36.88)
POD 17 (Negative)
|
POD 5 (29.5),
POD 9 (26),
POD 13 (29.17)
|
Lesion fluid
|
POD 14 (21.48),
POD 18 (Negative),
POD 22 (Negative)
|
POD 7 (27.28),
POD 11 (Negative),
POD 17 (32.47)
POD 21 (Negative)
|
POD 10 (30.02),
POD 15 (28.03),
POD 20 (24.71)
POD 24 (Negative)
|
POD 5 (Negative),
POD 9 (20.98),
POD 13 (36.12)
POD 17 (Negative)
|
POD 5 (Negative),
POD 9 (17.74),
POD 13 (25.58)
|
Lesion roof
|
POD 14 (24),
POD 18 (32.04),
POD 22 (Not collected)
|
POD 7 (26.99),
POD 11 (26.9),
POD 17 (27.73)
POD 21 (31.3)
|
POD 10 (not collected),
POD 15 (27.36),
POD 20 (31.08)
POD 24 (35.3)
|
POD 5 (Negative),
POD 9 (29.77),
POD 13 (30.52)
POD 17 (Negative)
|
POD 5 (33.58),
POD 9 (22),
POD 13 (31.82)
|
Lesion crust
|
POD 14 (Not collected),
POD 18 (27.13),
POD 22 (Negative)
|
POD 7 (not collected),
POD 11 (26.28),
POD 17 (28.81)
POD 21 (28.1)
|
POD 10 (27.75),
POD 15 (29.18),
POD 20 (29.93)
POD 24 (Negative)
|
POD 5 (26.77),
POD 9 (27.25),
POD 13 (not collected)
POD 17 (37.14)
|
POD 5 (30.68),
POD 9 (23.54),
POD 13 (32.98)
|
· Haematological and Biochemical findings (normal range)
|
Haemoglobin (11.6-15.5 g/dl)
|
15.4
|
14.4
|
15.6
|
11.3
|
12.3
|
TLC (4000-10000/µL)
|
11,700
|
8,900
|
7,500
|
7,300
|
12,100
|
Differential count [Neutrophils/Lymphocytes
/Monocytes/Eosinophils]
|
50/37/21/5
|
89/61/21/13
|
48/33/10/6
|
65/19/29/15
|
55/38/6/1
|
Platelet (150000-450000/µL)
|
3.87 lakhs
|
2.57 lakhs
|
1.34 lakhs
|
1.6 lakhs
|
2.2 lakhs
|
Haematocrit (35.5-48.6 %)
|
44.1
|
41.6
|
45.6
|
34.5
|
35
|
Serum urea (17-49 mg/dl)
|
25
|
30
|
19
|
15
|
22
|
Serum creatinine (0.6 to 1.2 mg/dl)
|
0.85
|
0.76
|
0.5
|
0.8
|
0.65
|
Serum sodium (136-146 mmol/L)
|
142
|
140
|
136
|
133
|
136
|
Serum potassium (3.5-4.5 mEq/L)
|
4.6
|
5.7
|
5.3
|
5.2
|
4.3
|
AST(24-40 U/L)
|
31
|
32
|
32
|
34
|
25
|
ALT (44-80 U/L)
|
30
|
31
|
38
|
31
|
22
|
ALP (50-130 U/L]
|
82
|
88
|
92
|
102
|
90
|
Total bilirubin (0.1-1.2 mg/dl)
|
0.57
|
0.6
|
0.5
|
0.3
|
0.4
|
Direct bilirubin (upto 0.5 mg/dl)
|
0.30
|
0.2
|
0.28
|
0.16
|
0.16
|
RBS (<200 m/dl)
|
143
|
100
|
102
|
98
|
110
|
|
Recovered without complications
|
Recovered without complications
|
Recovered without complications
|
Recovered without complications
|
Recovering without complications
|