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Research Article
Denes Farago
Budapest University of Technology and Economics
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
It is important to know the biomechanical properties of an allograft. This is because when looking to do a transplant of a tendon, the tendon must have very similar biomechanical properties to the original tendon. To use tendon allografts, it is critical to properly sterilize the tendon before implantation. In past decades, several sterilization procedures have been used. This study aimed to systematically evaluate the existing literature to compare the values of failure load/ultimate strength and Young’s modulus of elasticity of different sterilization methods on commonly used tendon allografts. Five major scientific literature databases (Web of Science, Science Direct, Scopus, PLOS ONE, Hindawi) and additional sources were used.
Results
Studies used had to show a particular sterilization method. Studies were identified to meet the following inclusion criteria: is a controlled laboratory study, gamma irradiation (dose reported), and other sterilization methods. Search for publications dated between 1991 and March 31st, 2020. A total of 54 articles have been included. Data collected from the full-text assessment included: a) author and date, b) type of tendon, c) type of sterilization, d) sterilization dose, and g) measured and calculated parameters. Different types of sterilization methods used before tendon durability testing have been identified and categorized.
Conclusions
Identified sterilization methods (gamma irradiation, dry ice, supercritical carbon dioxide (SCCO2), BioCleanse, Electron Beam) are offered as a catalog of potential methods.
As a result of the broadness of the present research, it provides an overview of sterilization methods. It does not stand for the state-of-the-art of any single process.
Keywords
tendon, sterilization, irradiation, Ebeam, dry ice, SCCO2, Biocleanse, mechanical properties
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 18 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 22 Mar, 2021
Reviews received
Received 19 Feb, 2021
Reviewers agreed
On 18 Feb, 2021
Reviewers invited
Invitations sent on 17 Feb, 2021
Editor assigned
On 17 Feb, 2021
Editor invited
On 17 Feb, 2021
Submission checks complete
On 17 Feb, 2021
First submitted
On 03 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at BMC Musculoskeletal Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Denes Farago
Budapest University of Technology and Economics
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 18 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 22 Mar, 2021
Reviews received
Received 19 Feb, 2021
Reviewers agreed
On 18 Feb, 2021
Reviewers invited
Invitations sent on 17 Feb, 2021
Editor assigned
On 17 Feb, 2021
Editor invited
On 17 Feb, 2021
Submission checks complete
On 17 Feb, 2021
First submitted
On 03 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
It is important to know the biomechanical properties of an allograft. This is because when looking to do a transplant of a tendon, the tendon must have very similar biomechanical properties to the original tendon. To use tendon allografts, it is critical to properly sterilize the tendon before implantation. In past decades, several sterilization procedures have been used. This study aimed to systematically evaluate the existing literature to compare the values of failure load/ultimate strength and Young’s modulus of elasticity of different sterilization methods on commonly used tendon allografts. Five major scientific literature databases (Web of Science, Science Direct, Scopus, PLOS ONE, Hindawi) and additional sources were used.
Results
Studies used had to show a particular sterilization method. Studies were identified to meet the following inclusion criteria: is a controlled laboratory study, gamma irradiation (dose reported), and other sterilization methods. Search for publications dated between 1991 and March 31st, 2020. A total of 54 articles have been included. Data collected from the full-text assessment included: a) author and date, b) type of tendon, c) type of sterilization, d) sterilization dose, and g) measured and calculated parameters. Different types of sterilization methods used before tendon durability testing have been identified and categorized.
Conclusions
Identified sterilization methods (gamma irradiation, dry ice, supercritical carbon dioxide (SCCO2), BioCleanse, Electron Beam) are offered as a catalog of potential methods.
As a result of the broadness of the present research, it provides an overview of sterilization methods. It does not stand for the state-of-the-art of any single process.
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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