Supplementary Data
Supplementary materials are available online.
Notes
Acknowledgments
We thank Maria Romero (Trialance, S.L.) for medical writing support, Santiago Perez Hoyos (Unitat d’Estadística i Bioinformàtica (UEB)) for the statistical calculations and Mercedes Vila for her assistance in the methodology and implementation of the project.
Funding
This work was supported by the Spanish Clinical Research Network (SCReN), co-finaced by the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación, through the project PI15/02161 and by the Plan Nacional de I+D+i 2013-016 and ISCIIII, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003)‐co-financed by European Development Regional Fund “A way to achieve Europe”, Operative program Intelligent Growth 2014-2020.
Transparency declaration
The authors declare that they have no conflict of interest.
Author’s contributions
Dr Rodriguez-Pardo and Dr Pigrau contributed to its Conception, Clinical trial design, Protocol, Data collection, Patient recruitment, Data analysis and writing the paper with the assistance of a medical writer. Dr Corona and Dr Almirante contributed to its Conception, Clinical trial design and Reviewing and editing the manuscript. All the other authors participated in Patient recruitment, Data collection, Reviewing and editing the manuscript. All authors approved the submitted versions, had full access to the data (under confidentiality agreements), and vouch for the accuracy and completeness of the data and for the fidelity of the trial to the protocol.
LIST OF COLLABORATORS/GROUP OF INVESTIGATORS FOR BARIFER CLINICAL TRIAL
This is a multicentre study. In each institution there are many researchers that have helped to make this study possible. We are deeply indebted to these collaborators, who are:
Jaume Mestre and Maria del Mar Villar (Internal Medicine Department, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain)
Álvaro Corrales Díaz and Myriam Rodríguez Rodríguez (Orthopedic Surgery Department Hospital Universitario Virgen Macarena, Seville, Spain)
Nerea Hernández González and Lorena Díez López (Orthopedic Surgery Department, Hospital Universitario Cruces, Vizcaya, Spain)
Javier Cobo (Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Madrid, Spain) and Isabel Perez Millán (Geriatrics Department, Hospital Ramón y Cajal, Madrid, Spain).
Mª Isabel Perez Núñez (Orthopedic Surgery Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain), M Carmen Fariñas Alvarez (Infectious Diseases Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain), Hospital and Zoilo Yusta Escudero (Geriatrics Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain),
Elena Muñez Rubio, Isabel Sánchez Romero (Hospital Universitario Puerta de Hierro, Majadahonda, Spain).
Cristina Dauder Gallego (Orthopedic Surgery Department, Hospital Universitario Fundación Alcorcón. Madrid, Spain), Oriol Martin Segarra (Internal Medicine Department, Infectious Diseases Division, Hospital Universitario Fundación Alcorcón. Madrid, Spain), Jesús Ignacio Collado Álvarez and Mª Mar Bermejo Olano (Internal Medicine Department Hospital Universitario Fundación Alcorcón. Madrid, Spain).
Oscar Murillo (Infectious Diseases Department, Hospital Universitari de Bellvitge, Barcelona, Spain), Salvador Pedrero (Orthopedic Surgery Department Hospital Universitari de Bellvitge, Barcelona, Spain).
Melcior Riera (Internal Medicine Department, Hospital Universitario Son Espasses, Palma de Mallorca, Spain).
María Gomáriz Díaz (Microbiology Department. Hospital Universitario Donostia), Gaspar De la Herrán (Orthopedic Surgery Department. Hospital Universitario Donostia), H. Azkune (Infectious Diseases Department Hospital Universitario Donostia, San Sebastián, Spain).
Marta Almenara Fernández, Eduard Ramírez Bermejo, Judit Martínez Zaragoza, (Infectious Diseses Department, Hospital Santa Creu i Sant Pau, Barcelona, Spain) Ferran Navarro Risueño (Microbiology Department, Hospital Santa Creu i Sant Pau, Barcelona, Spain)