This preprint is under consideration at BMC Urology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Yu Bai
Yunnan Cancer Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% of intermediate-risk patients with clinically non-palpable inguinal lymph nodes after i nguinal lymph node dissection( ILND ) . It means approximately 70% of patients are unable to benefit from ILND who might suffered from the complications of surgery. We hope some biomarkers could be found which are able to predict the outcome before surgery and reflect the inguinal lymph nodes metastasis.
Methods: A total of 349 consecutive patients of penile cancer in Yunnan cancer hospital in China between October 2002 and December2017. 225 was succeed to follow-up. According to the (AUROC) curve, we get the cut-off point, K-M analysis and multivariate logistic regression models and Bivariate correlations were used to detect the results. The association between NLR,LMR,PLR,LDH and Overall survival(OS),progression free survival(PFS) , inguinal lymph node (N stage) was analyzed with K-M analysis, univariable, multivariable logistic regression and Kendall’s tau-b correlation coefficient.
Results: Multivariate analysis reveal that only PLR was significant independent factor which is associated with inferior OS and PFS; Age and LDH was associated with inferior OS; Lymph node and metastatic status remained significant for OS and PFS as NCCN and EAU Guidelines indicated; the ages, tumor type, initial treatment and NLR LMR were not significant in predicting both OS and PFS. NLR, LMR and PLR were corresponded to N stage, while LDH was not associated with the N stage based on logistic regression model analysis. NLR, LMR and PLR were found weakly related to N stage through an application of Kendall’s tau-b correlation coefficient.
Conclusions: PLR was significant independent factors for OS and PFS, Age and LDH was significant independent factors for OS. NLR, LMR, PLR was corresponded to N stage.
Keywords
penile cancer, NLR, LMR, PLR, LDH
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
No community comments so far
Editorial decision: Minor revision
On 04 May, 2020
Version 3
Posted 15 May, 2020
No comments provided
Editorial decision: Minor revision
On 01 May, 2020
Editor assigned
On 29 Apr, 2020
Editor invited
On 28 Apr, 2020
Submission checks complete
On 05 Jul, 2019
No comments provided
Editorial decision: Minor revision
On 23 Apr, 2020
Review #1 received
Received 24 Feb, 2020
Reviewers invited
Invitations sent on 20 Feb, 2020
Reviewer #1 agreed
On 20 Feb, 2020
Editor assigned
On 03 Jan, 2020
Submission checks complete
On 02 Jan, 2020
Editor invited
On 02 Jan, 2020
No comments provided
Editorial decision: Major revision
On 13 Dec, 2019
Review #2 received
Received 22 Nov, 2019
Reviewer #2 agreed
On 14 Nov, 2019
Review #1 received
Received 10 Oct, 2019
Reviewer #1 agreed
On 30 Sep, 2019
Reviewers invited
Invitations sent on 31 Jul, 2019
Editor assigned
On 18 Jul, 2019
Submission checks complete
On 17 Jul, 2019
Editor invited
On 05 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
This preprint is under consideration at BMC Urology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Yu Bai
Yunnan Cancer Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
No community comments so far
Editorial decision: Minor revision
On 04 May, 2020
Version 3
Posted 15 May, 2020
No comments provided
Editorial decision: Minor revision
On 01 May, 2020
Editor assigned
On 29 Apr, 2020
Editor invited
On 28 Apr, 2020
Submission checks complete
On 05 Jul, 2019
No comments provided
Editorial decision: Minor revision
On 23 Apr, 2020
Review #1 received
Received 24 Feb, 2020
Reviewers invited
Invitations sent on 20 Feb, 2020
Reviewer #1 agreed
On 20 Feb, 2020
Editor assigned
On 03 Jan, 2020
Submission checks complete
On 02 Jan, 2020
Editor invited
On 02 Jan, 2020
No comments provided
Editorial decision: Major revision
On 13 Dec, 2019
Review #2 received
Received 22 Nov, 2019
Reviewer #2 agreed
On 14 Nov, 2019
Review #1 received
Received 10 Oct, 2019
Reviewer #1 agreed
On 30 Sep, 2019
Reviewers invited
Invitations sent on 31 Jul, 2019
Editor assigned
On 18 Jul, 2019
Submission checks complete
On 17 Jul, 2019
Editor invited
On 05 Jul, 2019
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% of intermediate-risk patients with clinically non-palpable inguinal lymph nodes after i nguinal lymph node dissection( ILND ) . It means approximately 70% of patients are unable to benefit from ILND who might suffered from the complications of surgery. We hope some biomarkers could be found which are able to predict the outcome before surgery and reflect the inguinal lymph nodes metastasis.
Methods: A total of 349 consecutive patients of penile cancer in Yunnan cancer hospital in China between October 2002 and December2017. 225 was succeed to follow-up. According to the (AUROC) curve, we get the cut-off point, K-M analysis and multivariate logistic regression models and Bivariate correlations were used to detect the results. The association between NLR,LMR,PLR,LDH and Overall survival(OS),progression free survival(PFS) , inguinal lymph node (N stage) was analyzed with K-M analysis, univariable, multivariable logistic regression and Kendall’s tau-b correlation coefficient.
Results: Multivariate analysis reveal that only PLR was significant independent factor which is associated with inferior OS and PFS; Age and LDH was associated with inferior OS; Lymph node and metastatic status remained significant for OS and PFS as NCCN and EAU Guidelines indicated; the ages, tumor type, initial treatment and NLR LMR were not significant in predicting both OS and PFS. NLR, LMR and PLR were corresponded to N stage, while LDH was not associated with the N stage based on logistic regression model analysis. NLR, LMR and PLR were found weakly related to N stage through an application of Kendall’s tau-b correlation coefficient.
Conclusions: PLR was significant independent factors for OS and PFS, Age and LDH was significant independent factors for OS. NLR, LMR, PLR was corresponded to N stage.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Loading...