Total 288 Ross-308 male broiler chicks were randomly distributed in a complete block design at 2×3 (Two different phytochemicals, i.e., Azadirachta indica, and Curcuma longa at three different levels, i.e., 0, 0.063, and 0.125% of the basal diet) factorial arrangement. Final live weight (FLW), average daily feed intake (ADFI), average daily gain (ADG), feed efficiency (FE), carcass characteristics, cardio-pulmonary morphometry, haemato-biochemical indices, gut morphology, ileal nutrient digestibility, tibia morphometry, meat quality and fatty acid profile were measured. Results indicated that, supplementation of Azadirachta indica leaf meal (AILM) decreased the FLW, ADFI, ADG, gizzard weight, right ventricular diameter and increased the FE, tibia calcium content, left ventricular weight and the ratio of right and left ventricle. The AILM substantially increased the malonaldehyde concentration in the Pectoralis major muscle of the broiler chicken at 7th and day 14th days. The Curcuma longa powder (CLP) decreased the FLW, ADFI and ADG without affecting the FE and increased the weight of right ventricle, left ventricle and tibia length. The AILM and CLP interacted to decrease the ADFI, total saturated fatty acid content and increase the FE, ω-6, ω-9, total unsaturated fatty acids, total poly-unsaturated fatty acids and the ratio of total unsaturated: saturated fatty acid in the breast muscle of the broiler chicken. It was concluded that Azadirachta indica and Curcuma longa in combination with fish oil improved the FE and meat quality of the broiler chicken at the expense of ADFI and ADG.