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Research article
Hui Su
HwaMei Hospital, University of Chinese Academy of Sciences
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
In theory, proximal gastrectomy with double-tract reconstruction (PG-DT) was superior to total gastrectomy (TG) in hematologic and nutritional outcomes. However, its clinical effects in proximal early gastric cancer (EGC) have been controversial.
Methods
The purpose of this study was to investigate the outcomes of laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DT) for proximal EGC. For this systematic review and meta-analysis, we searched for articles published before December of 2018 in the following databases: PubMed, Web of Science, EBSCO, Medline, and Cochrane Library.
Results
The results showed no significant difference in the anastomotic stenosis (OR=0.91, 95%CI=0.33-2.50, p=0.85) and reflux esophagitis (OR=1.87, 95%CI=0.62-5.65, p=0.27) between LPG-DT and laparoscopic total gastrectomy (LTG). The vitamin B12 supplementation rate in the LPG-DT group was lower than the LTG group (OR=0.06, 95%Cl=0.01-0.59, p=0.02).
Conclusions
Due to comparable clinical effect, PG-DT is comparable to TG for patients with proximal EGC. In addition, LPG-DT not only appears superior to TG in terms of preventing vitamin B12 deficiency, but also does not increase the risk of anastomotic stricture and reflux esophagitis.
Keywords
Proximal gastrectomy; Double-tract; Total gastrectomy; Early gastric cancer; Meta-analysis
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CURRENT STATUS: Published
View the published article at BMC Surgery.
No community comments so far
Submission checks complete
On 07 Nov, 2019
Editorial decision: Accept
On 14 Aug, 2019
Version 1
Posted 02 Aug, 2019
No comments provided
Editorial decision: Minor revision
On 12 Aug, 2019
Review #2 received
Received 06 Aug, 2019
Reviewer #2 agreed
On 27 Jul, 2019
Reviewers invited
Invitations sent on 18 Jul, 2019
Reviewer #1 agreed
On 18 Jul, 2019
Review #1 received
Received 18 Jul, 2019
Editor assigned
On 05 Jul, 2019
Submission checks complete
On 04 Jul, 2019
Editor invited
On 04 Jul, 2019
Metrics
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Subject Areas
Oncology
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A new preprint design is coming!
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See the published version of this preprint at BMC Surgery.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Hui Su
HwaMei Hospital, University of Chinese Academy of Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Surgery.
No community comments so far
Submission checks complete
On 07 Nov, 2019
Editorial decision: Accept
On 14 Aug, 2019
Version 1
Posted 02 Aug, 2019
No comments provided
Editorial decision: Minor revision
On 12 Aug, 2019
Review #2 received
Received 06 Aug, 2019
Reviewer #2 agreed
On 27 Jul, 2019
Reviewers invited
Invitations sent on 18 Jul, 2019
Reviewer #1 agreed
On 18 Jul, 2019
Review #1 received
Received 18 Jul, 2019
Editor assigned
On 05 Jul, 2019
Submission checks complete
On 04 Jul, 2019
Editor invited
On 04 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Surgery.
Background
In theory, proximal gastrectomy with double-tract reconstruction (PG-DT) was superior to total gastrectomy (TG) in hematologic and nutritional outcomes. However, its clinical effects in proximal early gastric cancer (EGC) have been controversial.
Methods
The purpose of this study was to investigate the outcomes of laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DT) for proximal EGC. For this systematic review and meta-analysis, we searched for articles published before December of 2018 in the following databases: PubMed, Web of Science, EBSCO, Medline, and Cochrane Library.
Results
The results showed no significant difference in the anastomotic stenosis (OR=0.91, 95%CI=0.33-2.50, p=0.85) and reflux esophagitis (OR=1.87, 95%CI=0.62-5.65, p=0.27) between LPG-DT and laparoscopic total gastrectomy (LTG). The vitamin B12 supplementation rate in the LPG-DT group was lower than the LTG group (OR=0.06, 95%Cl=0.01-0.59, p=0.02).
Conclusions
Due to comparable clinical effect, PG-DT is comparable to TG for patients with proximal EGC. In addition, LPG-DT not only appears superior to TG in terms of preventing vitamin B12 deficiency, but also does not increase the risk of anastomotic stricture and reflux esophagitis.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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