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Research article
Younger age of patients with myocardial infarction correlates with higher number of relatives with history of premature atherosclerosis
Michał Ambroziak
Medical center of Postgraduate Education
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3172-0719
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cardiovascular Disorders.
Background. Premature coronary artery disease belongs to the most pressing global issues in a modern cardiology. Family history appears to be one of the most important and significant risk factors in young patients with myocardial infarction (MI). The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients <50 years with myocardial infarction (MI) compared to patients ≥ 50 years with MI and to young healthy people.
Methods. The studied group (MI<50) consisted of 240 patients aged 26-49 years with MI. The control groups consisted of 240 patients (MI≥50) with MI aged 50-92 years and 240 healthy people aged 30-49 years.
Results. There were statistically significant differences between the MI<50 and MI≥50 and young healthy groups regarding family history of premature MI/ischaemic stroke and percent of patients with of ≥2 relatives affected including parents, children, siblings, siblings of parents and grandparents (10.8%, 2.9%, 3.7%, respectively; p<0.0001). There was a statistically significant negative correlation between the age of the first episode of MI and the number of relatives with a history of premature MI/stroke (r=0.249, p<0.05) within all MI patients. Statistically significant differences between MI<50 and MI≥50 groups as well as young healthy control group were revealed regarding prevalence of smoking, body mass index (BMI), LDL, HDL, triglycerides (TG) and glucose levels.
Conclusions. Younger age of patients with myocardial infarction correlates with a higher number of relatives with a history of premature MI/ischemic stroke. Thus, the family history of premature atherosclerosis involving not only the first-, but also the second-degree relatives, seems to be valuable and could be considered in an individual CVD risk evaluation in young people.
Keywords
myocardial infarction at a young age, premature coronary artery disease, CVD family history
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CURRENT STATUS: Published
Published
On 11 Sep, 2020
No community comments so far
Editorial decision: Accept
On 20 Aug, 2020
Editor assigned
On 17 Aug, 2020
Submission checks complete
On 16 Aug, 2020
Editor invited
On 16 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 03 Aug, 2020
Review #2 received
Received 01 Aug, 2020
Reviewer #2 agreed
On 24 Jul, 2020
Review #1 received
Received 22 Jul, 2020
Reviewer #1 agreed
On 20 Jul, 2020
Reviewers invited
Invitations sent on 19 Jul, 2020
Editor assigned
On 12 Jul, 2020
Editor invited
On 11 Jul, 2020
Submission checks complete
On 06 Jul, 2020
Version 1
Posted 15 Apr, 2020
No comments provided
Editorial decision: Major revision
On 01 Jun, 2020
Review #2 received
Received 29 May, 2020
Review #1 received
Received 25 May, 2020
Reviewer #2 agreed
On 19 May, 2020
Reviewers invited
Invitations sent on 06 May, 2020
Reviewer #1 agreed
On 06 May, 2020
Editor assigned
On 08 Apr, 2020
Submission checks complete
On 07 Apr, 2020
Editor invited
On 07 Apr, 2020
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This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Younger age of patients with myocardial infarction correlates with higher number of relatives with history of premature atherosclerosis
Michał Ambroziak
Medical center of Postgraduate Education
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3172-0719
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Published
On 11 Sep, 2020
No community comments so far
Editorial decision: Accept
On 20 Aug, 2020
Editor assigned
On 17 Aug, 2020
Submission checks complete
On 16 Aug, 2020
Editor invited
On 16 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 03 Aug, 2020
Review #2 received
Received 01 Aug, 2020
Reviewer #2 agreed
On 24 Jul, 2020
Review #1 received
Received 22 Jul, 2020
Reviewer #1 agreed
On 20 Jul, 2020
Reviewers invited
Invitations sent on 19 Jul, 2020
Editor assigned
On 12 Jul, 2020
Editor invited
On 11 Jul, 2020
Submission checks complete
On 06 Jul, 2020
Version 1
Posted 15 Apr, 2020
No comments provided
Editorial decision: Major revision
On 01 Jun, 2020
Review #2 received
Received 29 May, 2020
Review #1 received
Received 25 May, 2020
Reviewer #2 agreed
On 19 May, 2020
Reviewers invited
Invitations sent on 06 May, 2020
Reviewer #1 agreed
On 06 May, 2020
Editor assigned
On 08 Apr, 2020
Submission checks complete
On 07 Apr, 2020
Editor invited
On 07 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cardiovascular Disorders.
Background. Premature coronary artery disease belongs to the most pressing global issues in a modern cardiology. Family history appears to be one of the most important and significant risk factors in young patients with myocardial infarction (MI). The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients <50 years with myocardial infarction (MI) compared to patients ≥ 50 years with MI and to young healthy people.
Methods. The studied group (MI<50) consisted of 240 patients aged 26-49 years with MI. The control groups consisted of 240 patients (MI≥50) with MI aged 50-92 years and 240 healthy people aged 30-49 years.
Results. There were statistically significant differences between the MI<50 and MI≥50 and young healthy groups regarding family history of premature MI/ischaemic stroke and percent of patients with of ≥2 relatives affected including parents, children, siblings, siblings of parents and grandparents (10.8%, 2.9%, 3.7%, respectively; p<0.0001). There was a statistically significant negative correlation between the age of the first episode of MI and the number of relatives with a history of premature MI/stroke (r=0.249, p<0.05) within all MI patients. Statistically significant differences between MI<50 and MI≥50 groups as well as young healthy control group were revealed regarding prevalence of smoking, body mass index (BMI), LDL, HDL, triglycerides (TG) and glucose levels.
Conclusions. Younger age of patients with myocardial infarction correlates with a higher number of relatives with a history of premature MI/ischemic stroke. Thus, the family history of premature atherosclerosis involving not only the first-, but also the second-degree relatives, seems to be valuable and could be considered in an individual CVD risk evaluation in young people.
Figure 1
Figure 2