Younger age of patients with myocardial infarction correlates with higher number of relatives with history of premature atherosclerosis
Background. Premature coronary artery disease belongs to the most pressing global issues in a modern cardiology. Family history appears to be one of the most important and significant risk factors in young patients with myocardial infarction (MI). The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients <50 years with myocardial infarction (MI) compared to patients ≥ 50 years with MI and to young healthy people.
Methods. The studied group (MI<50) consisted of 240 patients aged 26-49 years with MI. The control groups consisted of 240 patients (MI≥50) with MI aged 50-92 years and 240 healthy people aged 30-49 years.
Results. There were statistically significant differences between the MI<50 and MI≥50 and young healthy groups regarding family history of premature MI/ischaemic stroke and percent of patients with of ≥2 relatives affected including parents, children, siblings, siblings of parents and grandparents (10.8%, 2.9%, 3.7%, respectively; p<0.0001). There was a statistically significant negative correlation between the age of the first episode of MI and the number of relatives with a history of premature MI/stroke (r=0.249, p<0.05) within all MI patients. Statistically significant differences between MI<50 and MI≥50 groups as well as young healthy control group were revealed regarding prevalence of smoking, body mass index (BMI), LDL, HDL, triglycerides (TG) and glucose levels.
Conclusions. Younger age of patients with myocardial infarction correlates with a higher number of relatives with a history of premature MI/ischemic stroke. Thus, the family history of premature atherosclerosis involving not only the first-, but also the second-degree relatives, seems to be valuable and could be considered in an individual CVD risk evaluation in young people.
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On 11 Sep, 2020
On 20 Aug, 2020
On 17 Aug, 2020
On 16 Aug, 2020
On 16 Aug, 2020
On 03 Aug, 2020
Received 01 Aug, 2020
On 24 Jul, 2020
Received 22 Jul, 2020
On 20 Jul, 2020
Invitations sent on 19 Jul, 2020
On 12 Jul, 2020
On 11 Jul, 2020
On 06 Jul, 2020
Posted 15 Apr, 2020
On 01 Jun, 2020
Received 29 May, 2020
Received 25 May, 2020
On 19 May, 2020
Invitations sent on 06 May, 2020
On 06 May, 2020
On 08 Apr, 2020
On 07 Apr, 2020
On 07 Apr, 2020
Younger age of patients with myocardial infarction correlates with higher number of relatives with history of premature atherosclerosis
On 11 Sep, 2020
On 20 Aug, 2020
On 17 Aug, 2020
On 16 Aug, 2020
On 16 Aug, 2020
On 03 Aug, 2020
Received 01 Aug, 2020
On 24 Jul, 2020
Received 22 Jul, 2020
On 20 Jul, 2020
Invitations sent on 19 Jul, 2020
On 12 Jul, 2020
On 11 Jul, 2020
On 06 Jul, 2020
Posted 15 Apr, 2020
On 01 Jun, 2020
Received 29 May, 2020
Received 25 May, 2020
On 19 May, 2020
Invitations sent on 06 May, 2020
On 06 May, 2020
On 08 Apr, 2020
On 07 Apr, 2020
On 07 Apr, 2020
Background. Premature coronary artery disease belongs to the most pressing global issues in a modern cardiology. Family history appears to be one of the most important and significant risk factors in young patients with myocardial infarction (MI). The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients <50 years with myocardial infarction (MI) compared to patients ≥ 50 years with MI and to young healthy people.
Methods. The studied group (MI<50) consisted of 240 patients aged 26-49 years with MI. The control groups consisted of 240 patients (MI≥50) with MI aged 50-92 years and 240 healthy people aged 30-49 years.
Results. There were statistically significant differences between the MI<50 and MI≥50 and young healthy groups regarding family history of premature MI/ischaemic stroke and percent of patients with of ≥2 relatives affected including parents, children, siblings, siblings of parents and grandparents (10.8%, 2.9%, 3.7%, respectively; p<0.0001). There was a statistically significant negative correlation between the age of the first episode of MI and the number of relatives with a history of premature MI/stroke (r=0.249, p<0.05) within all MI patients. Statistically significant differences between MI<50 and MI≥50 groups as well as young healthy control group were revealed regarding prevalence of smoking, body mass index (BMI), LDL, HDL, triglycerides (TG) and glucose levels.
Conclusions. Younger age of patients with myocardial infarction correlates with a higher number of relatives with a history of premature MI/ischemic stroke. Thus, the family history of premature atherosclerosis involving not only the first-, but also the second-degree relatives, seems to be valuable and could be considered in an individual CVD risk evaluation in young people.
Figure 1
Figure 2