Prevalence and Risk Factors of Postpartum Depression among Women Attending Primary Healthcare Centers in Northern of West Bank: A cross-sectional study, 2022

DOI: https://doi.org/10.21203/rs.3.rs-2096403/v1

Abstract

Background

Postpartum depression (PPD) has a huge negative impact on the health of the mother and the family, both physically and mentally. Few postpartum depression studies have been done in Palestine. This study aimed to examine the prevalence of PPD and the most probable risks among Palestinian women in the northern West Bank.

Methods

This is a cross-sectional study of 380 mothers, ages of 18 and 44, visiting vaccination clinics with their infants after 7–12 weeks of delivery between 1 May 2022 and 30 June 2022. Postpartum women seeking care at the seven largest primary health care centers of the Ministry of Health in four cities in the Northern West Bank were asked to complete a self-administered questionnaire that included Edinburgh Postnatal Depression Scale and demographic and birth details. A score of 13 or higher was used to indicate PPD risk. Descriptive and analytical analyses were performed using SPSS version 20. The level of significance was set at 5%.

Results

The median age of the participants was 27 with a range of 26. A total of 129 women had an EPDS score of 13 or more, giving a prevalence rate of post-partum depression of 33.9%. The predictors of postpartum depression were stressful life events during pregnancy (p value 0.003, OR: 2.1, 95% CI [1.27–3.4]), vacuum use during delivery (p value 0.002, OR: 4, 95% CI: [1.64–9.91]), low social support (p value less than 0.001, OR: 2.5, 95%CI: [1.7–4.2]) and husband’s low level of education (p value less than 0.001, OR: 5.2, 95%CI: [2.7–10]).

Conclusion

The study showed a high prevalence of PPD among Palestinian mothers in the northern of West Bank. This will emphasize the importance of PPD screening and early intervention, especially among vulnerable women.

1. Introduction:

Women go through emotional and psychological changes during the perinatal period making them more susceptible to psychiatric disorders, such as postpartum depression (1).

Postpartum depression may impair parenting skills and judgment (2), decrease enjoyment of the maternal role, and create poor mother-infant interactions. Mothers with PPD show an early cessation of breastfeeding and less care of their infants which leads to decreased immunity and puts babies at risk for delayed growth and development (3). Moreover, maternal mental illness can also affect a child's emotional and cognitive development (4). Undetected PPD imposes a heavy cost on society since the mother is less able to fulfill her responsibility as a caregiver (5).

The Diagnostic and Statistical Manual of Mental Disorders defines postpartum depression as the "Occurrence of a major depressive episode (MDE) within four weeks after birth, which may involve irritability, excessive crying, or panic" (6). However, these episodes might begin or persist during the first year after delivery (7).

In low- and middle-income countries, PPD affects up to 48.5% of women (4), but just 6.5–12.9% of women in high-income nations (8). Postpartum depression has been linked to several risk factors, including stressful life events, a history of depression, not breastfeeding, the first delivery, and having a poor body image. Other risk factors include having a poor relationship with their partner and having a lower socioeconomic status (9).

In the West Bank, a cross-sectional study conducted in Nablus city in 2013 showed a prevalence of 17% with depression during pregnancy and a history of mental illness being the highest associated risk factors (10). Another study in Bethlehem in 2016 showed a prevalence of 27.7%, with multiparity and unplanned pregnancy having the highest association with PPD (9).

A recent systematic analysis of the frequency of postpartum depression in Arab nations revealed that 1 in 5 women experience the condition, with some of the most common risk factors being low socioeconomic status, unwanted pregnancy, low social and husband support, stressful life events during pregnancy and personal or family history of depression (11).

A variety of instruments have been used to screen for PPD including the Beck Depression Inventory (BDI) and the Mini International Neuropsychiatric Interview (MINI) (12). However, EPDS is most suited for postnatal and primary care settings (13) and several studies have been done to assess its validity in varying cut-off scores (14, 15, 16). The USPTFS recommends screening pregnant and post-partum women with EPDS but doesn't specify a cut-off value (17).

Despite the impact of post-partum depression, few studies have been conducted in Palestine. Those that did had low sample size and sampled only one city. This study aims to investigate the prevalence of postpartum depression among Palestinian women attending vaccination clinics at primary health care centers in the northern of west bank in 2022 and to pinpoint risk factors for the condition.

2. Methods:

2.1. Design and Setting:

This study is a descriptive cross-sectional study that was conducted in the northern West Bank between 1 May 2022 and 30 June 2022.

Women visiting vaccination clinics at the seven largest primary health care centers of the Ministry of Health in four cities (Nablus, Tulkarem, Jenin, and Qalqelia) with their infants after 7–12 weeks of delivery were asked to participate. These clinics are the only to provide vaccination services and post-partum women are expected to be seen there with their infants. Mother who agreed to participate were consented and given a self-administered questionnaire including the Arabic version of EPDS.

2.2. Inclusion Criteria:

Women who were between 18–44 years old, 7–12 weeks after delivery, and able to read the Arabic version of the questionnaire were recruited to participate.

2.3. Sample Size and Sampling Method:

The sample size was calculated with the Raosoft sample size calculator. Based on the annual report of the Palestinian Central Bureau of Statistics, there were 28273 live births in the northern of West Bank in 2020 (18). The minimum sample size was 380 at 95% confidence level, 5% margin of error and 50% response distribution.

In order to have a representative sample of the target population to achieve the aim of the study, a proportionate sample was calculated as shown in Table 1. Then, a convenient sample was collected from women presenting to the vaccination clinics at the largest primary care centers in West Bank/Palestine in May and June, 2022.

Table 1

Sample size.

City

(N) of live birth

%

Sample size

(%X380)

Nablus

10547

37.3%

142

Jenin

9185

32.5%

124

Tulkarm

4957

17.5%

66

Qalqilia

3584

12.7%

48

Total

28273

100%

380

 

2.4. Instrument:

Data was collected using a 3 part self-administered questionnaire; 1)A pre-defined checklist used to collect data about socio-demographic factors, pregnancy and birth-related factors, baby-related factors, and psychological history (10). 2) The Maternal Social Support Scale (MSSS), which is a 6-question 5 point-Likert scale used to assess the social support mothers were given after giving birth. The possible highest score is 30 with a score of 6–18 on the MSSS considered low social support, 19–24 medium support, and > 24 adequate support. The reliability of the scale (Cronbach's alpha) was 0.71–0.90(19). 3) The Arabic version of the Edinburgh Postnatal Depression Scale (EPDS), a self-reporting screening tool, composed of 10 items reflect the mother's emotional experience over the past 7 days. Responses were scored 0–3 indicating the severity of manifestations, with a maximum score of 30.

There is a debate on the single cut-off with the highest sensitivity and specificity. No studies were conducted in Palestine to examine the EPDS validity and reliability. However, a recent systematic review in the Arab world showed that most studies used 13 or greater as a cut off to maximize consistency with other studies. The validity and reliability of the Arabic version of the Edinburgh Postnatal Depression Scale were reviewed with internal reliability of .84 (alpha Cronbach) (13).

2.5. Data Analysis:

Incomplete questionnaires were discarded. Data were entered into Excel and analyzed using SPSS program version 20. We used univariate descriptive analysis for all variables.

Bivariate analysis was used to study the relationship between dependent and independent variables and test the null hypothesis. P value < 0.05 was considered significant.

All significant variables were exported to multivariate analysis using logistic regression to attenuate the effect of cofounders.

2.6. Ethical Consideration:

All methods involving human participants in this study were conducted per ethical research standards. The study was conducted in conformity with the ethical norms of An-Najah National University (ANNU). The Ministry of Health approved authorization for the study to be conducted in PHC settings, and participants were approached and invited voluntarily to participate. Participants were assured of their confidentiality and anonymity.

3. Results:

3.1. Descriptive results:

3.1.1. Characteristics of participants:

A total of 380 women with the median age of 27 and a range of 26, with the majority of them falling between the ages of 26 and 35 (n = 208, 54.7%) participated.

The majority (84%, n = 319) were city dwellers, highly educated (studied beyond secondary school) (70.3%, n = 267), and married to highly educated men (47.6%, n = 181).

Additionally, most of them were still married at the time of the research (99.5%, n = 378), had government insurance (46.3%, n = 176), and were unemployed (79.5%, n = 302). Their salary ranged from 2000 to less than 4000 shekel (55.5%, n = 211). See Table 2.

Table 2

Association between PPD and Socio-demographic characteristics. (n = 380)

Variable

Categories

EPDS ≥ 13

EPDS < 13

Total

+P value

Age(years)

18–25

47

93

140(36.8%)

0.704

26–35

69

139

208(54.7%)

36–44

13

19

32(8.4%)

Median:27, Range: 26

Age at marriage(years)

≤ 25

102

218

320(84.2%)

0.109

26–35

24

31

55(14.5%)

≥ 36

3

2

5(1.3%)

Median:22, Range: 34

Residence

Refugee Camp

2

10

12(3.1%)

0.362

Village

15

34

49(12.9%)

City

112

207

319(84%)

Education(mother)

≤ 6

3

16

19(5%)

0.166

7–12

36

58

94(24.8%)

> 12 years

90

177

267(70.3%)

Occupation

Housewife

97

205

302(79.5%)

0.334

Employed

27

39

66(17.4%)

other

5

7

12(3.2%)

Insurance

Non

46

72

118(31.1%)

0.481

Governmental

58

118

176(46.3%)

Private

14

37

51(13.4%)

^NGOs

11

24

35(9.2%)

Income(shekel)

< 2000

7

18

25(6.6%)

0.804

2000 – <4000

72

139

211(55.5%)

≥ 4000

50

94

144(37.9)

Median:3000, Range: 12600

Education (husband)

≤ 6

39

30

69(18.2%)

< 0.001

7–12

45

85

130(34.2%)

> 12 years

45

136

181(47.6%)

Actual marital status

Still married

129

249

378(99.4%)

0.597

Separated

0

1

1(0.3%)

Other

0

1

1(0.3%)

+ Chi-squared test; Significant level at p < 0.05. ^Nongovernmental organization.

3.1.2. Birth and child related characteristics of the participants:

As Tables 3 and 4 show, most of the participants were multiparas (68.7%, n = 261), without any previously diagnosed chronic illness (87.1%, n = 331).

Most pregnancies occurred without complications (63%, n = 239) and in private hospitals (61.3%, n = 233) by Caesarean section (51.1%, n = 194). The majority of vaginal deliveries were not assisted by vacuum (86%, n = 160). However, of those that had a vaginal delivery, more than half underwent episiotomy repair (59.7%, n = 111).

Of the 380 women, 200 had boys (52.6%), 344 were full-term (90.5%), 375 were healthy (98.7%), with weights within the normal range (85.5%, n = 325). Most reported only breast feeding (40.8%, n = 155) or mixed with formula feeding (39.7%, n = 151).

Table 3

Association between Birth-related Factors and PPD

Variable

Categories

EPDS ≥ 13

EPDS < 13

Total

+P value

Prim parity

Yes

53

66

119(31.3%)

0.003

No

76

185

261(68.7%)

Complications

Yes

55

86

141(37%)

0.110

No

74

165

239(63%)

Place of birth

Governmental

41

87

128(33.7%)

0.472

Private

84

149

233(61.3%)

Agency

4

13

17(4.5%)

Others

0

2

2(0.5%)

Type of birth

Vaginal

63

123

186(48.9%)

0.975

C.S

66

128

194(51.1%)

Vacuum

N = 186

Yes

18

8

26(14%)

< 0.001

No

45

115

160(86%)

Episiotomy

N = 186

Yes

38

73

111(59.7%)

0.899

No

25

50

75(40.3%)

Planned Pregnancy

Yes

103

181

284(74.7%)

0.1

No

26

70

96(25.3%)

Presence of Chronic disease

Yes

12

37

49(12.9%)

0.134

No

117

214

331(87.1%)

Rating of medical service

Excellent

67

101

168(44.2%)

0.123

Very well

34

75

109(28.7%)

Good

20

41

61(16.1%)

Acceptable

5

23

28(7.4%)

Bad

3

11

14(3.7%)

+ Chi-squared test; Significant level at p < 0.05

Table 4

Associations between Baby-related Factors and PPD

Variable

Categories

EPDS ≥ 13

EPDS < 13

Total

+P value

Sex

Male

63

137

200(52.6%)

0.288

Female

66

114

180(47.4%)

Desired Sex

Male

36

59

95(25%)

0.531

Female

36

67

103(27.1%)

No difference

125

57

182(47.9%)

Premature

Yes

12

24

36(9.5%)

0.935

No

117

227

344(90.5%)

NICU admission

Yes

15

22

37(9.7%)

0.373

No

114

229

343(90.3%)

Illness

Yes

2

3

5(1.3%)

0.552*

No

127

248

375(98.7%)

Weight(kg)

≤ 2.5

17

36

53(13.9%)

0.853

2.51–4.49

111

214

325(85.5%)

≥ 4.5

1

1

2(0.5%)

Mdian:3.1, Range:3.6

Feeding type

Breastfeeding

47

108

155(40.8%)

0.052

Formula

20

54

74(19.5%)

Mixed

62

89

151(39.7%)

+ Chi-squared test; Significant level at p < 0.05. *Fisher’s exact test

3.1.3. Psycho-social factors:

Most participants reported no personal or family history of mental illness (98.4% and 77.4% respectively). Nearly half (47.9%) reported stressful life events during pregnancy. The MSSS median was 20 (with a range of 22). Most women rated their families' support in the medium range (53.7%, n = 204). See Tables 5 and 6.

Table 5

Association between Psychological characteristics and PPD

Variable

Categories

EPDS ≥ 13

EPDS < 13 Depressed

Total

+P value

Personal history of mental illness

Yes

1

5

6(1.6%)

0.368

No

128

246

374(98.4%)

Treatment (N = 6)

Yes

0

2

2(33.3%)

0.667*

No

3

1

4(66.7%)

Family history of mental illness

Yes

4

14

18(4.7%)

0.555

No

102

192

294(77.4%)

Don’t know

23

45

68(17.9%)

Stressful events in pregnancy

Yes

78

104

182(47.9%)

< 0.001

No

51

147

198(52.1%)

+ Chi-squared test; Significant level at p < 0.05. *Fisher’s exact test

Table 6

Association between Social Support and PPD

Variable

Categories

EPDS > = 13

EPDS < 13

N (%)

+P value

MSSS

Low

77

91

168(44.2%)

< 0.001

Medium

51

153

204(53.7%)

Adequate

1

7

8(2.1%)

Median: 20, Range: 22

+ Chi-squared test; Significant level at p < 0.05. MSSS: Maternal Social Support Scale

3.2. Postpartum depression prevalence:

At the time of our study 33.9% (n = 129) showed the risk of post-partum depression using the EDPS. The highest score was 28 and the lowest score was zero, with all answers negative for suicide attempts (Question 10 in the EPDS). The median score was 11.5 with a range of 28.

3.3. Factors associated with PPD:

Bivariate analysis (Chi-squared test and Fishers’ exact test as appropriate) was applied to all variables in the descriptive part of the results. Factors significantly associated with postpartum depression were lower level education of the husband, primiparity, vacuum use, stressful events during pregnancy, and low social support for the mother. A multi-logistic regression showed all factors remained significantly associated with PPD except primiparity. See Table 7.

Women experiencing stressful events during pregnancy were shown to be 2.1 times more likely to develop PPD (p value 0.003, OR: 2.1, 95% CI [1.27–3.4]), as did those with vacuum extraction of the baby (p value 0.002, OR: 4.0, 95%CI: [1.64–9.91]). Additionally, marriage to a man with a low level of education(6 years and less) increased the risk of PPD five times more than marriage to a man with a high degree of education (more than 12 years) (p value less than 0.001, OR: 5.2, 95%CI: [2.7–10]).

Moreover, mothers with low social support were shown to be at increased risk of developing PPD when compared to mothers with both medium and adequate support (p value less than 0.001, OR: 2.5, 95%CI: [1.7–4.2]). Social support in both medium and adequate categories was calculated as one group due to low sample size in the adequate group.

Table 7

Predictors of PPD by multivariate logistic regression:

Factor

 

EPDS

Total

OR

95% CI

P-Value

 

≥ 13

< 13

N

 

N

%

N

%

Prim parity

Yes

53

44.5%

66

55.5%

119

1.67

[0.99–2.8]

0.054

No(ref)

76

29.1%

185

70.9%

261

1

 

Stressful events in pregnancy

Yes

78

42.9%

104

57.1%

182

2.1

[1.27–3.4]

0.003

No(ref)

51

25.8%

147

74.2%

198

1

 

Education (husband) (yrs)

≤ 6

39

56.5%

30

43.5%

69

5.2

[2.7–10]

< 0.001

7–12

45

34.6%

85

65.4%

130

1.7

[1.002–2.92]

0.049

> 12 (ref)

45

24.9%

136

75.1%

181

1

 

MSSS

Low

77

45.8%

91

54.2%

168

2.5

[1.7–4.2]

< 0.001

Medium + Adequate(ref)

52

24.5%

160

75.5%

212

1

 

Vacuum use

Yes

18

69.2%

8

30.8%

26

4

[1.64–9.91]

0.002

No(ref)

45

28.1%

115

71.9%

160

1

 
OR: Odds Ratio; CI: Confidence Interval. ref: reference level. +Significant level at p < 0.05

4. Discussion:

Postpartum depression affects 17.22% of the global population(20). Moreover, PPD is becoming more widely acknowledged as a global public health problem that may have far-reaching effects on a person's life, including effects on job, family, and the child. Despite the impact of PPD, only two studies were conducted in West Bank in the previous ten years.

Our study showed that prevalence of postpartum depression (women who scored 13 and more in the EPDS) was much higher than studies that used the EPDS in Nablus and Bethlehem which reported 17% an overall prevalence of PPD ( 8.9% scored 13 and more, 8.1% scored 10–12 on EPDS), 27.7% (score of 11 and more on the EPDS) respectively (10, 9). The rise is is not surprising and may be explained by the continued pressures Palestinians experience due to the restrictions and uncertainties imposed by being an occupied nation. Since the elected Palestinian government was politically and economically boycotted, living circumstances have become worse, leading to increased levels of unemployment, poverty, and internal conflict in Palestine as well as more limitations on access to healthcare (21, 18). These stressors result in mental instability and increase susceptibility to mental illnesses including PPD (1).

The increased prevalence of PPD in Palestine is similar to nearby Arab countries(20). Surprisingly, Palestine’s prevalence of 33.9% is reasonable in comparison to what is published in nearby Arab region; recent systematic review study was held in the Arab region, 2020 and showed 8–40% range of PPD in Arab countries (11). Another meta-analysis across the Middle East countries reported 27% prevalence (22). In Saudi Arabia prevalence of PPD increased from 25.7% in 2017 to 38.5% in 2020 (23, 3). Another study in Damascus, 2017 reported a prevalence of 28.2% (EDPS score 13 and more) (24). Higher prevalence was seen in Jordan; an article was published in 2021 and reported 52.9% prevalence between Jordanian women (EDPS score 12 and more) (25). The global rise of PPD prevalence could be explained by the continuing COVID pandemic impact on health sectors both physically and mentally. Recent studies on the effect of the COVID-19 pandemic on PPD revealed increased levels of post-partum depression caused by increased fear (26, 27).

While reviewing the literature, we found variations in risk factors for PPD.Our study adds lack of social support, the husband’s low level of education, the occurrence of stressful events while pregnant and the use of vacuum as significant risk factors related to PPD. Our first two risk factors were also found in the Middle-East systematic review and meta-analysis (22). However, stressful events in pregnancy or vacuum are new findings.

Vacuum extraction is reported by mothers as a negative experience which indirectly increases the risk of PPD due to trauma to birth canal, post-delivery complications, increased pain and delay of return to normal activities (28). All of this explains the significant association between vacuum and PPD which was reported in our study.

Another negative experience that showed significant association with PPD was stressful events during pregnancy, these includes mother argued with partner more than usual, separation, divorce, mother was in a physical fight, moved to new address, had a lot of unpaid bills, job loss, and close family member sick or died (29). Several studies showed that stress increases amygdala activity which leads to mood changes and increasing probability of depression (30).

This study showed a significant association between low maternal social support and PPD; a new baby comes with many more duties and requirements, but assistance and support help mothers to cope faster (31). Significant association between social support and PPD was also found in studies in nearby Arab countries with the same cultural and religious characteristics of Palestine (32).

Our significant negative association between higher levels of the husband’s education and PPD was also found in other studies across the world, India and East Turkey as an example (33, 34). This can be contributed to the increased knowledge of women’s needs and the ability to provide good strategies of support. Here in Palestine, in order to provide acceptable living conditions, husbands with low educational level spend long working hours away from their wives limiting their ability to provide the needed support.

5. Limitations:

As a cross-sectional study our findings don’t show causal relationships between variables. Because of limited time and resources we were unable to assess PPD across all of Palestine or in the UNRWA clinics that serve the Palestinian refugees. The numbers of participants who lived in rural (villages) and in the refugee camps were too small to assess PPD risks associated with those living situations. Moreover, the self-report answers may be limited by recall bias. The study was conducted during the pandemic, a very difficult time across the globe and PPD may be higher due to the stresses of COVID. However, this study examines PPD prevalence and associated risk factors across a larger region in Palestine than prior studies.

6. Conclusion And Recommendations:

In conclusion, given the high prevalence of PPD in the northern of West Bank, Palestine, we recommend that antenatal clinics to expand their services from only maternal physical care to include mental health as well. Mothers should be screened for a range of stressors during pregnancy and efforts should be made to address them. This might include referrals to treat PPD with medication or offer therapeutic counseling support. Home health nurses have been used in other countries. Moreover, easy access to post-partum clinics should be offered for providing scheduled meetings including close family members to assure adequate social support especially for women whom vacuum was used during delivery or with stressful events during pregnancy. Results of this study could be used to guide policies and to help redirect the focus of future studies.

Abbreviations:

PPD: Post-Partum Depression

EPDS: Edinburgh Postnatal Depression Scale

WHO: World Health Organization

MDE: Major Depressive Episode

SD: Standard Deviation

BDI: Beck Depression Inventory

MINI: Mini International Neuropsychiatric Interview

USPSTF: United States Preventive Services Task Force

OR: Odds Ratio

CI: Confidence Interval.

Declarations:

a. Ethical Consideration and Consent to Participate

All methods involving human participants in this study were conducted per ethical research standards. The study was conducted in conformity with the ethical norms of An-Najah National University (ANNU). The Ministry of Health approved authorization for the study to be conducted in PHC settings, and participants were approached and invited voluntarily to participate. Participants were assured of their confidentiality and anonymity

This study was performed in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. It was approved by the Institutional Review Board (IRB) of An-Najah National University (No Med March 2022/8).

b. Consent to participate

All subjects involved in the research were invited to participate voluntarily after the study's purpose as well as the risks and the benefits of participation were explained. Informed consent was obtained from all individual participants is included in the stud

c. Availability of data and materials

The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.

d. Conflict of interest

No potential conflict of interest was reported by the authors.

e. Funding

No funding was received

f. Acknowledgment

We thank the heads of the MOH centers of primary health care in Palestine for providing access to patients. We appreciate the support from the family medicine department at Al-Najah National University. Special thanks to the mothers that agreed to participate with the hope of improving the lives of mothers in Palestine

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