See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research article
Rashad Abdul-Ghani
Faculty of Medicine and Health Sciences, Sana'a University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7181-1108
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Hematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan.
Methods: A comparative, cross-sectional study was conducted at the Medical Technology Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured and their median values were statistically compared.
Results: The majority of P. falciparum-infected patients (64.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular Hb and mean corpuscular Hb concentration were significantly lower in P. falciparum-infected patients, with anemia being significantly higher among infected patients than malaria-negative subjects (60.4% vs. 29.5%, respectively). The median total WBC count was non-significantly higher in P. falciparum-infected patients, with leucopenia being non-significantly different between both groups. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly higher among infected patients than malaria-negative subjects (72.4% vs. 5.0%, respectively).
Conclusions: Most falciparum malaria infections among patients in Kosti city of the White Nile State – Sudan are of low-level parasitemia. Nevertheless, falciparum malaria is significantly associated with anemia and thrombocytopenia with lower median values of Hb, RBC count, MCH, MCHC and platelet count in P. falciparum-infected patients than malaria-negative subjects. In contrast, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended.
Keywords
Falciparum malaria, Hematological indices, Anemia, Thrombocytopenia, Sudan
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
Version 2
Posted 29 Mar, 2021
Community comments: 1
Editorial decision: Major revision
On 01 Apr, 2021
Reviewer #4 agreed
On 14 Mar, 2021
Reviewer #3 agreed
On 11 Mar, 2021
Review #1 received
Received 09 Mar, 2021
Reviewer #2 agreed
On 09 Mar, 2021
Review #2 received
Received 09 Mar, 2021
Reviewer #1 agreed
On 08 Mar, 2021
Editor assigned
On 23 Feb, 2021
Reviewers invited
Invitations sent on 23 Feb, 2021
Submission checks complete
On 23 Feb, 2021
Editor invited
On 23 Feb, 2021
First submitted
On 17 Feb, 2021
Archived Versions
Posted to Research Square
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Rashad Abdul-Ghani
Faculty of Medicine and Health Sciences, Sana'a University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7181-1108
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
Version 2
Posted 29 Mar, 2021
Community comments: 1
Editorial decision: Major revision
On 01 Apr, 2021
Reviewer #4 agreed
On 14 Mar, 2021
Reviewer #3 agreed
On 11 Mar, 2021
Review #1 received
Received 09 Mar, 2021
Reviewer #2 agreed
On 09 Mar, 2021
Review #2 received
Received 09 Mar, 2021
Reviewer #1 agreed
On 08 Mar, 2021
Editor assigned
On 23 Feb, 2021
Reviewers invited
Invitations sent on 23 Feb, 2021
Submission checks complete
On 23 Feb, 2021
Editor invited
On 23 Feb, 2021
First submitted
On 17 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Infectious Diseases.
Background: Hematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan.
Methods: A comparative, cross-sectional study was conducted at the Medical Technology Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured and their median values were statistically compared.
Results: The majority of P. falciparum-infected patients (64.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular Hb and mean corpuscular Hb concentration were significantly lower in P. falciparum-infected patients, with anemia being significantly higher among infected patients than malaria-negative subjects (60.4% vs. 29.5%, respectively). The median total WBC count was non-significantly higher in P. falciparum-infected patients, with leucopenia being non-significantly different between both groups. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly higher among infected patients than malaria-negative subjects (72.4% vs. 5.0%, respectively).
Conclusions: Most falciparum malaria infections among patients in Kosti city of the White Nile State – Sudan are of low-level parasitemia. Nevertheless, falciparum malaria is significantly associated with anemia and thrombocytopenia with lower median values of Hb, RBC count, MCH, MCHC and platelet count in P. falciparum-infected patients than malaria-negative subjects. In contrast, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
Loading...