Ethics approval and consent to participate
Written informed consent and assent were obtained from the parent/guardian and adolescent, respectively, to participate in the ABCD Study. The University of California, San Diego provided centralized institutional review board (IRB) approval and each participating site received local IRB approval:
• Children’s Hospital Los Angeles, Los Angeles, California
• Florida International University, Miami, Florida
• Laureate Institute for Brain Research, Tulsa, Oklahoma
• Medical University of South Carolina, Charleston, South Carolina
• Oregon Health and Science University, Portland, Oregon
• SRI International, Menlo Park, California
• University of California San Diego, San Diego, California
• University of California Los Angeles, Los Angeles, California
• University of Colorado Boulder, Boulder, Colorado
• University of Florida, Gainesville, Florida
• University of Maryland at Baltimore, Baltimore, Maryland
• University of Michigan, Ann Arbor, Michigan
• University of Minnesota, Minneapolis, Minnesota
• University of Pittsburgh, Pittsburgh, Pennsylvania
• University of Rochester, Rochester, New York
• University of Utah, Salt Lake City, Utah
• University of Vermont, Burlington, Vermont
• University of Wisconsin—Milwaukee, Milwaukee, Wisconsin
• Virginia Commonwealth University, Richmond, Virginia
• Washington University in St. Louis, St. Louis, Missouri
• Yale University, New Haven, Connecticut
All methods were carried out in accordance with relevant guidelines and regulations.
Consent for publication
Not applicable
Availability of data and materials
Data used in the preparation of this article were obtained from the ABCD Study (https://abcdstudy.org), held in the NIMH Data Archive (NDA). Investigators can apply for data access through the NDA (https://nda.nih.gov/).
Competing interests
The authors declare that they have no competing interests.
Funding
J.M.N. was funded by the National Institutes of Health (K08HL159350), the American Heart Association Career Development Award (CDA34760281), and the Doris Duke Charitable Foundation (2022056). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Author’s contributions
J.H.R. was responsible for the co-development of the research study design, methods, and data analysis; she also drafted the initial manuscript. K.T.G, A.T., and D.B.J. co-developed the study design, methods, and formal analysis; they also provided oversight and participated in the revision of the manuscript. G.S and O.M.S. completed the data cleaning and critically reviewed the manuscript. J.M.N provided supervision; he also co-developed the conceptualization of the study, methods, and supported the analysis and manuscript revision. All authors approved the final submitted version.
Acknowledgements
The ABCD Study was supported by the Nacional Institutes of Health and additional federal partners under award numbers U01DA041022, U01DA041025, U01DA041028, U01DA041048, U01DA041089, U01DA041093, U01DA041106, U01DA041117, U01DA041120, U01DA041134, U01DA041148, U01DA041156, U01DA041174, U24DA041123, and U24DA041147. A full list of supporters is available at https://abcdstudy.org/federal-partners/. A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/principal-investigators.html. ABCD consortium investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report.