Chemical chain reactions are known to enable extremely sensitive detection schemes in chemical, biological, and medical analysis, and have even been used in the search for dark matter. Here we show that coherent, ultracold chemical reactions harbor great potential for quantum metrology: In an atom-molecule Bose-Einstein condensate (BEC), a weak external perturbation can modify the reaction dynamics and lead to the coherent creation of molecules in an atom-dominant regime which can be selectively detected with modern spectroscopic techniques. This promises to substantially improve the viability of previously proposed BEC-based sensors for acceleration, gravitational waves, and other physical quantities, including the detection of dark matter, that so far relied on the detection of the tiny density modulations caused by the creation of single phonons.