See the published version of this preprint at Systematic Reviews.
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Protocol
Naseer Ally
University of the Witwatersrand
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6676-9352
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction
Microphthalmos and nanophthalmos are uncommon ocular conditions, whereby affected eyes have smaller dimensions compared to the normal population. Microphthalmos and nanophthalmos present several challenges to ophthalmologists; They have spontaneous and post-operative sequelae such as high hyperopia, angle-closure glaucoma, uveal effusion syndrome, and retinal detachment.
This systematic review and meta-analysis intends to assess the prevalence of both the spontaneous complications associated with nanophthalmos and microphthalmos, as well as the post-surgical complications associated with nanophthalmos or microphthalmos.
Methods and analysis
Articles will be searched for, on four online databases: PubMed, EMBASE, Scopus and Web of Science. Two independent reviewers will identify the studies according to prespecified inclusion and exclusion criteria. Relevant data will be extracted and assessed for the risk of bias in each article. The data will then be pooled to determine the prevalence of complications among patients with microphthalmos and nanophthalmos. If any preventative measures are associated with lower risks of developing complications, these will be expressed as odds ratios.
Discussion
Although nanophthalmos is an uncommon condition that affects the eye, its management and complications can be sight-threatening. Thus, it is important to counsel parents and patients correctly upon diagnosis and prior to any surgical intervention. This can only be done if the overall prevalence of complications is known.
Registration
This systematic review has been submitted to PROSPERO for registration.
Keywords
Microphthalmos, Nanophthalmos, Complications, Hyperopia, Uveal effusion, Glaucoma
This is a list of supplementary files associated with this preprint. Click to download.
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at Systematic Reviews.
Version 1
Posted 10 Feb, 2021
No community comments so far
Editorial decision: Revise before peer review
On 08 Jun, 2021
Editor assigned
On 08 Jun, 2021
Editor invited
On 08 Jun, 2021
Submission checks complete
On 06 Feb, 2021
First submitted
On 19 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Systems Biology
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Systematic Reviews.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Protocol
Naseer Ally
University of the Witwatersrand
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6676-9352
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Systematic Reviews.
Version 1
Posted 10 Feb, 2021
No community comments so far
Editorial decision: Revise before peer review
On 08 Jun, 2021
Editor assigned
On 08 Jun, 2021
Editor invited
On 08 Jun, 2021
Submission checks complete
On 06 Feb, 2021
First submitted
On 19 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Systems Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Systematic Reviews.
Introduction
Microphthalmos and nanophthalmos are uncommon ocular conditions, whereby affected eyes have smaller dimensions compared to the normal population. Microphthalmos and nanophthalmos present several challenges to ophthalmologists; They have spontaneous and post-operative sequelae such as high hyperopia, angle-closure glaucoma, uveal effusion syndrome, and retinal detachment.
This systematic review and meta-analysis intends to assess the prevalence of both the spontaneous complications associated with nanophthalmos and microphthalmos, as well as the post-surgical complications associated with nanophthalmos or microphthalmos.
Methods and analysis
Articles will be searched for, on four online databases: PubMed, EMBASE, Scopus and Web of Science. Two independent reviewers will identify the studies according to prespecified inclusion and exclusion criteria. Relevant data will be extracted and assessed for the risk of bias in each article. The data will then be pooled to determine the prevalence of complications among patients with microphthalmos and nanophthalmos. If any preventative measures are associated with lower risks of developing complications, these will be expressed as odds ratios.
Discussion
Although nanophthalmos is an uncommon condition that affects the eye, its management and complications can be sight-threatening. Thus, it is important to counsel parents and patients correctly upon diagnosis and prior to any surgical intervention. This can only be done if the overall prevalence of complications is known.
Registration
This systematic review has been submitted to PROSPERO for registration.
This is a list of supplementary files associated with this preprint. Click to download.
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