1. Safavi M, Honarmand A. The effects of propofol, ketamine and combination of them in prevention of coughing and laryngospasm in patients awakening from general anesthesia: A randomized, placebo-controlled, double blind clinical trial. Advanced biomedical research. 2016; 5:64.
2. Kim ES, Bishop MJ. Cough during emergence from isoflurane anesthesia. Anesthesia & Analgesia. 1998; 87:1170-4
3. Leech P, Barker J, Fitch W. Proceedings: changes in intracranial pressure and systemic arterial pressure during the termination of anaesthesia. Br J Anaesth. 1974; 46: 315–6.
4. Bidwai AV, Bidwai VA, Rogers CR, Stanley TH. Blood-pressure and pulse-rate responses to endotracheal extubation with and without prior injection of lidocaine. Anesthesiology. 1979; 51:171–3.
5. Irwin RS. Complications of cough: ACCP evidence‑based clinical practice guidelines. Chest. 2006; 129:54S‑8S.
6. Elbers LPB, Squizzato A. Thyroid Disorders and Hemostasis. Semin Thromb Hemost.2018; 44:676-82.
7. Nath P, Williams S, Herrera Méndez LF, Massicotte N, Girard F, Ruel M. Alkalinized Lidocaine Preloaded Endotracheal Tube Cuffs Reduce Emergence Cough After Brief Surgery: A Prospective Randomized Trial. Anesthesia & analgesia. 2018; 126:615-20.
8. Lee JS, Choi SH, Kang YR, Kim Y, Shim YH. Efficacy of a single dose of dexmedetomidine for cough suppression during anesthetic emergence: a randomized controlled trial. Canadian journal of anaesthesia. 2015; 62:392-8.
9. Botros JM, Mahmoud AMS, Ragab SG, Ahmed MAA, Roushdy HMS, Yassin HM, et al. Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering A randomized controlled trial. BMC anesthesiology.2018;18:179.
10. Guler G, Akin A, Tosun Z, Eskitascoglu E, Mizrak A, Boyaci A. Single-dose dexmedetomidine attenuates airway and circulatory reflexes during extubation. Acta Anaesthesiol Scand. 2005; 49:1088-91
11. Turan G, Ozgultekin A, Turan C, Dincer E, Yuksel G. Advantageous effects of dexmedetomidine on haemodynamic and recovery responses during extubation for intracranial surgery. Eur J Anaesthesiol. 2008; 25:816–20.
12. Shabnum T, Ali Z, Naqash IA, Mir AH, Azhar K, Zahoor SA, et al. Effects of Lignocaine Administered Intravenously or Intratracheally on Airway and Hemodynamic Responses during Emergence and Extubation in Patients Undergoing Elective Craniotomies in Supine Position. Anesth Essays Res. 2017; 11:216-22.
13. Wang F, Zhong H, Xie X, Sha W, Li C, Li Z, et al. Effect of intratracheal dexmedetomidine administration on recovery from general anaesthesia after gynaecological laparoscopic surgery: a randomised double-blinded study. BMJ Open. 2018;8: e020614.
14. Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology.2000;93:858-75.
15. Koppert W, Ostermeier N, Sittl R, Weidner C, Schmelz M. Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain. 2000; 85:217–24
16. Wu CT, Borel CO, Lee MS, Yu JC, Liou HS, Yi HD, et al. The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy. Anesthesia & Analgesia. 2005;100: 448–53.
17. Souissi H, Fréchette Y, Murza A, Masse MH, Marsault É, Sarret P, et al. Intracuff 160 mg alkalinized lidocaine reduces cough upon emergence from N2O-free general anesthesia: a randomized controlled trial. Canadian journal of anaesthesia. 2016; 63:862-70.
18. Thapa P, Shrestha RR, Shrestha S, Bajracharya GR. Betamethasone gel compared with lidocaine jelly to reduce tracheal tube related postoperative airway symptoms: a randomized controlled trial. BMC Res Notes. 2017; 10:361.
19. Jee D, Park SY. Lidocaine sprayed down the endotracheal tube attenuates the airway-circulatory reflexes by local anesthesia during emergence and extubation. Anesthesia & Analgesia. 2003; 96:293-7.
20. Saghaei M, Reisinejad A, Soltani H. Prophylactic versus therapeutic administration of intravenous lidocaine for suppression of post-extubation cough following cataract surgery: a randomized double-blind placebo controlled clinical trial. Acta Anaesthesiologica Taiwanica. 2005; 43: 205–9.
21. George SE, Singh G, Mathew BS, Fleming D, Korula G. Comparison of the effect of lignocaine instilled through the endotracheal tube and intravenous lignocaine on the extubation response in patients undergoing craniotomy with skull pins: A randomized double-blind clinical trial. J Anaesthesiol Clin Pharmacol. 2013; 29:168-72.
22. Callaway JK, King RG. Effects of inhaled alpha 2-adrenoceptor and GABAB receptor agonists on citric acid-induced cough and tidal volume changes in guinea pigs. Eur J Pharmacol. 1992; 220:187–95.
23. Park JS, Kim KJ, Lee JH, Jeong WY, Lee JR. A Randomized Comparison of Remifentanil Target-Controlled Infusion Versus Dexmedetomidine Single-Dose Administration: A Better Method for Smooth Recovery from General Sevoflurane Anesthesia. American journal of therapeutics. 2016;23: e690-6.
24. Kim SY, Kim JM, Lee JH, Song BM, Koo BN. Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery. Br J Anaesth. 2013; 111: 222–8.
25. Polat R, Peker K, Baran I, Bumin Aydın G, Topçu Gülöksüz Ç, Dönmez A. Comparison between dexmedetomidine and remifentanil infusion in emergence agitation during recovery after nasal surgery: a randomized double-blind trial. Anaesthesist. 2015; 64: 740–6.
26. Lang BH, Yih PC. A review of risk factors and timing for postoperative hematoma after thyroidectomy: is outpatient thyroidectomy really safe? World journal of surgery. 2012; 36:2497-502.
27. Wojtczak B, Aporowicz M, Kaliszewski K. Consequences of bleeding after thyroid surgery - analysis of 7805 operations performed in a single center. Archives of medical science: AMS.2018;14:329-35.
28. Luthra A, Prabhakar H, Rath GP. Alleviating Stress Response to Tracheal Extubation in Neurosurgical Patients: A Comparative Study of Two Infusion Doses of Dexmedetomidine. J Neurosci Rural Pract. 2017;8: S49-56.
29. Haldar R, Dubey M, Rastogi A. Intravenous Lignocaine to Blunt Extubation Responses: A Double-Edged Sword. American journal of therapeutics. 2016;23: e646-8.
30. Uusalo P, Al-Ramahi D, Tilli I, Aantaa RA, Scheinin M, Saari TI. Subcutaneously administered dexmedetomidine is efficiently absorbed and is associated with attenuated cardiovascular effects in healthy volunteers. Eur J Clin Pharmacol. 2018; 74:1047-54.